Iodomethane

CH3I

iodomethane

CAS74-88-4
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
Danger

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Identification

CAS Number
74-88-4
EC Number
200-819-5
UN Number
2644
Index Number
602-005-00-9
PubChem CID
6328

Physical-chemical properties

Molecular Formula
CH3I
Molar Mass
141.94 g/mol
IUPAC Name
iodomethane

Chemical Identifiers

InChI
InChI=1S/CH3I/c1-2/h1H3
InChI Key
INQOMBQAUSQDDS-UHFFFAOYSA-N

Overview

Iodomethane (CAS 74-88-4) is a halogenated organic compound with methyl iodide structure used as methylating agent and chemical intermediate. This colorless volatile liquid, also known as methyl iodide, represents one of the most reactive alkyl halides in organic synthesis. With its molecular formula CH3I and molecular weight of 141.939 g/mol, iodomethane serves as a crucial building block in pharmaceutical manufacturing, agrochemical production, and advanced materials synthesis. The compound's high reactivity stems from the weak carbon-iodine bond, making it an excellent methylating agent for nucleophilic substitution reactions. Safety considerations are paramount when handling iodomethane, as it carries significant health hazards including carcinogenic properties (Category 2), acute toxicity, and potential for skin irritation. The substance requires careful storage under controlled conditions away from light and moisture, as it can decompose to form toxic iodine vapors. Like other methylating agents such as chloromethylbenzene, iodomethane demands specialized handling protocols and appropriate personal protective equipment. Primary industrial applications include pharmaceutical intermediate synthesis, where it serves as a methylating agent in the production of quaternary ammonium compounds and various drug molecules. The agrochemical industry utilizes iodomethane in pesticide manufacturing, while the electronics sector employs it in specialized etching processes. Research laboratories frequently use this compound for methylation reactions in organic synthesis, particularly in the preparation of methyl esters and ethers. OYSI maintains reliable supply chains for iodomethane, ensuring consistent availability for European industrial customers requiring this specialized methylating agent.

Safety & Classification

Danger
Classification:

Carc. 2; Acute Tox. 3 *; Acute Tox. 4 *; Acute Tox. 3 *; STOT SE 3; Skin Irrit. 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H351

Suspected of causing cancer.

H331

Toxic if inhaled.

H312

Harmful in contact with skin.

H301

Toxic if swallowed.

H335

May cause respiratory irritation.

H315

Causes skin irritation.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2644
ADR Class6.1
Packing GroupI
Tunnel CodeC/D
Proper Shipping NameMethyliodid
Marine PollutantNo

Frequently Asked Questions

What is iodomethane?

Iodomethane is an organohalogen chemical compound with the formula CH3I, also known as methyl iodide. This colorless liquid has a molecular weight of 141.939 g/mol and belongs to the alkyl halide family. It is classified as a dangerous substance with carcinogenic properties (Category 2) and acute toxicity. Iodomethane is highly volatile and reactive, making it valuable in various chemical synthesis applications but requiring careful handling due to its significant health hazards.

What are the physicochemical properties of iodomethane?

Iodomethane is a colorless liquid at room temperature with a sweet, ether-like odor. It has a high density due to the presence of iodine and is sparingly soluble in water but miscible with most organic solvents. The compound is highly volatile with a low boiling point, and it decomposes when exposed to light, often developing a yellow or brown coloration. Its molecular structure (CH3I) makes it a polar compound with significant reactivity towards nucleophiles.

What is iodomethane used for?

Iodomethane is primarily used as a methylating agent in organic synthesis, particularly in pharmaceutical and agrochemical manufacturing. It serves as an intermediate in the production of quaternary ammonium compounds, pharmaceuticals, and specialty chemicals. The compound is also utilized in research laboratories for methylation reactions and as a fumigant in certain industrial applications. Due to its high reactivity, it plays a crucial role in various chemical transformations where methyl group introduction is required.

How to handle iodomethane safely?

Iodomethane requires strict safety measures due to its carcinogenic and acutely toxic properties. Personal protective equipment must include chemical-resistant gloves, safety goggles, and respiratory protection when vapor exposure is possible. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation. Skin and eye contact must be avoided at all costs. Emergency shower and eyewash stations should be readily accessible, and personnel must be trained in proper handling procedures before use.

How to store iodomethane correctly?

Iodomethane must be stored in a cool, dark place away from heat sources and direct sunlight to prevent decomposition. The storage area should be well-ventilated and equipped with appropriate containment measures. Containers must be tightly sealed and made of compatible materials. The substance should be kept separate from oxidizing agents, bases, and metals. Secondary containment is recommended, and storage areas must be clearly marked with appropriate hazard warnings and restricted access controls.

What to do in case of contact with iodomethane?

Immediate action is required for any contact with iodomethane. For skin contact, remove contaminated clothing and flush the affected area with plenty of water for at least 15 minutes. In case of eye contact, rinse thoroughly with water and seek immediate medical attention. If inhaled, move the person to fresh air and provide respiratory support if needed. For ingestion, do not induce vomiting and seek emergency medical care immediately. Always consult a physician after any exposure incident.

How to dispose of iodomethane properly?

Iodomethane disposal must comply with local and national hazardous waste regulations due to its toxic and carcinogenic properties. The substance cannot be disposed of through regular waste streams and requires specialized hazardous waste treatment facilities. Small quantities should be collected in appropriate containers and labeled clearly. Incineration at high temperatures in licensed facilities is typically the preferred disposal method. Always consult with certified waste management companies and follow all applicable environmental regulations for proper disposal procedures.

How to transport iodomethane?

Iodomethane is classified under ADR Class 6.1 (Toxic substances) Packing Group I, indicating high toxicity requiring stringent transport regulations. It must be packaged in UN-approved containers with proper labeling including GHS06 and GHS08 pictograms and 'Danger' signal word. Transport vehicles must carry appropriate emergency equipment and documentation. Drivers require ADR certification for dangerous goods transport. The shipment must comply with quantity limitations and routing restrictions as specified in dangerous goods transport regulations.

Is iodomethane subject to specific regulations?

Iodomethane is subject to comprehensive chemical regulations including REACH registration requirements in Europe and CLP classification obligations. It carries multiple hazard classifications including Carcinogenic Category 2, Acute Toxicity Categories 3 and 4, and Skin Irritant Category 2. The substance requires safety data sheets, proper labeling with GHS pictograms, and may be subject to authorization or restriction procedures. Users must comply with occupational exposure limits and implement appropriate risk management measures as outlined in regulatory frameworks.

Where to buy iodomethane in Europe?

Iodomethane is available through OYSI, a European distributor specializing in technical chemical products. As a regulated dangerous substance requiring proper handling and documentation, it should only be purchased from qualified suppliers who can ensure compliance with all safety and regulatory requirements. OYSI provides the necessary technical support, safety documentation, and regulatory compliance assistance for European customers. Professional users should verify their qualifications and intended use before purchasing this controlled chemical substance.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.