Dichloromethylbenzene

C7H6Cl2

dichloromethylbenzene

CAS98-87-3
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
Danger

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Identification

CAS Number
98-87-3
EC Number
202-709-2
UN Number
1886
Index Number
602-058-00-8
PubChem CID
7411

Physical-chemical properties

Molecular Formula
C7H6Cl2
Molar Mass
161.03 g/mol
IUPAC Name
dichloromethylbenzene

Chemical Identifiers

InChI
InChI=1S/C7H6Cl2/c8-7(9)6-4-2-1-3-5-6/h1-5,7H
InChI Key
CAHQGWAXKLQREW-UHFFFAOYSA-N

Overview

Dichloromethylbenzene (CAS 98-87-3) is an aromatic chlorinated compound with two chlorine atoms attached to a methylbenzene structure, classified as a hazardous chemical requiring specialized handling protocols. This organic compound, with the molecular formula C7H6Cl2 and a molecular weight of 161.03 g/mol, belongs to the family of chlorinated aromatic hydrocarbons that are widely utilized in industrial chemical processes. Dichloromethylbenzene presents significant safety considerations due to its classification under multiple hazard categories, including suspected carcinogenicity (Carc. 2), acute toxicity, and potential for causing serious eye damage and skin irritation. The compound requires careful handling procedures and appropriate personal protective equipment, as indicated by its "Danger" signal word and ADR transport classification of 6.1. The chemical structure of dichloromethylbenzene makes it particularly valuable as an intermediate in organic synthesis, where it serves similar functions to related compounds such as chloromethylbenzene, though with enhanced reactivity due to the additional chlorine substitution. Its aromatic nature combined with the electron-withdrawing chlorine atoms creates specific reactivity patterns that are exploited in pharmaceutical manufacturing, particularly in the synthesis of active pharmaceutical ingredients where precise molecular modifications are required. Primary industrial applications include its use as a chemical intermediate in pharmaceutical synthesis, as a building block in specialty chemical production, and in the manufacture of agrochemical compounds. The compound's reactivity profile makes it especially suitable for nucleophilic substitution reactions and coupling processes in fine chemical manufacturing. OYSI maintains reliable supply chains for dichloromethylbenzene to support European industrial customers requiring this specialized chemical intermediate for their manufacturing processes.

Safety & Classification

Danger
Classification:

Carc. 2; Acute Tox. 3 *; Acute Tox. 4 *; STOT SE 3; Skin Irrit. 2; Eye Dam. 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H351

Suspected of causing cancer.

H331

Toxic if inhaled.

H302

Harmful if swallowed.

H335

May cause respiratory irritation.

H315

Causes skin irritation.

H318

Causes serious eye damage.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number1886
ADR Class6.1
Packing GroupII
Tunnel CodeD/E
Proper Shipping NameBenzylidenchlorid
Marine PollutantNo

Frequently Asked Questions

What is dichloromethylbenzene?

Dichloromethylbenzene is an aromatic organochlorine compound with the molecular formula C7H6Cl2 and CAS number 98-87-3. This chemical consists of a benzene ring substituted with two chlorine atoms and one methyl group, resulting in a molecular weight of 161.03 g/mol. It belongs to the family of chlorinated toluenes and is classified as a hazardous substance with multiple health and safety concerns including carcinogenic potential and acute toxicity.

What are the physicochemical properties of dichloromethylbenzene?

Dichloromethylbenzene is typically a colorless to pale yellow liquid at room temperature with a characteristic aromatic odor. As an aromatic chlorinated compound, it exhibits low water solubility but good solubility in organic solvents such as alcohols, ethers, and hydrocarbons. The presence of two chlorine substituents significantly affects its physical properties compared to toluene, including higher density and boiling point due to increased molecular weight and intermolecular forces.

What is dichloromethylbenzene used for?

Dichloromethylbenzene serves primarily as a chemical intermediate in organic synthesis and pharmaceutical manufacturing. It is commonly used in the production of dyes, pigments, and other aromatic compounds where selective chlorination patterns are required. The compound also finds applications in research laboratories for synthetic chemistry work and as a building block for more complex molecular structures. Its specific substitution pattern makes it valuable for targeted chemical transformations.

How to handle dichloromethylbenzene safely?

Dichloromethylbenzene requires strict safety protocols including chemical-resistant gloves, safety goggles, and protective clothing to prevent skin and eye contact. Work must be conducted in well-ventilated areas or under fume hoods due to its acute toxicity and potential carcinogenic properties. Respiratory protection may be necessary when ventilation is inadequate. Avoid contact with skin, eyes, and inhalation of vapors. Emergency eyewash stations and safety showers should be readily accessible.

How to store dichloromethylbenzene correctly?

Dichloromethylbenzene must be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Storage areas should be equipped with appropriate containment measures for spill control. Keep away from strong oxidizing agents and bases that may react with the compound. Secondary containment is recommended to prevent environmental contamination. Storage facilities should comply with local regulations for hazardous chemicals.

What to do in case of contact with dichloromethylbenzene?

Dichloromethylbenzene exposure requires immediate action depending on the contact route. For skin contact, remove contaminated clothing and wash thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15-20 minutes and seek medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician after significant exposure.

How to dispose of dichloromethylbenzene properly?

Dichloromethylbenzene disposal must comply with local, national, and EU waste regulations as a hazardous substance. The compound cannot be disposed of in regular waste streams and requires treatment by licensed hazardous waste disposal facilities. Incineration at high temperatures in approved facilities is typically the preferred method. Empty containers may also require special handling as hazardous waste. Always consult local environmental authorities for specific disposal requirements and approved waste management companies.

How to transport dichloromethylbenzene?

Dichloromethylbenzene is classified under ADR as Class 6.1 (toxic substances), Packing Group II, requiring specific transport regulations. Packages must be properly labeled with appropriate hazard symbols and UN identification numbers. Transport vehicles need placarding and drivers require ADR certification for dangerous goods. Shipping documentation must include proper shipping names and emergency response information. Only authorized carriers experienced in hazardous material transport should handle shipments.

Is dichloromethylbenzene subject to specific regulations?

Dichloromethylbenzene falls under EU REACH regulation requiring registration for manufacture or import above one tonne annually. The substance is classified under CLP regulation with multiple hazard classifications including carcinogenicity category 2 and acute toxicity. Companies must maintain safety data sheets and ensure proper classification, labeling, and packaging. While not currently listed as SVHC, its carcinogenic properties mean regulatory status may evolve, requiring ongoing compliance monitoring.

Where to buy dichloromethylbenzene in Europe?

Dichloromethylbenzene is available through OYSI, a specialized European distributor of technical chemicals serving industrial and research customers. OYSI provides comprehensive documentation including safety data sheets, certificates of analysis, and regulatory compliance information required for this hazardous substance. As an established chemical distributor, OYSI ensures proper handling, packaging, and transport according to ADR regulations while supporting customers with technical expertise and regulatory guidance throughout Europe.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.