6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one
C10H9Cl2NO
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Identification
- CAS Number
- 118289-55-7
- EC Number
- 421-320-0
- UN Number
- 3077
- Index Number
- 606-091-00-9
- PubChem CID
- 10609474
Physical-chemical properties
- Molecular Formula
- C10H9Cl2NO
- Molar Mass
- 230.09 g/mol
- IUPAC Name
- 6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one
Chemical Identifiers
- InChI
- InChI=1S/C10H9Cl2NO/c11-2-1-6-3-7-4-10(14)13-9(7)5-8(6)12/h3,5H,1-2,4H2,(H,13,14)
- InChI Key
- ZTQQXEPZEYIVDK-UHFFFAOYSA-N
Overview
6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one (CAS 118289-55-7) is a chlorinated indolinone derivative with significant aquatic toxicity requiring specialized handling protocols. This synthetic organic compound belongs to the indolinone family, characterized by its bicyclic structure containing both chlorinated substituents and a lactam functionality. The molecular formula C10H9Cl2NO reflects its dichlorinated nature, with chlorine atoms positioned strategically on both the aromatic ring and the ethyl side chain. With a molecular weight of 230.09 g/mol, this compound exhibits moderate molecular complexity typical of pharmaceutical intermediates and specialty chemicals. The compound's safety profile is dominated by its environmental hazard classification as Aquatic Acute 1 and Aquatic Chronic 1, indicating severe toxicity to aquatic organisms with long-lasting effects. The GHS09 pictogram and "Warning" signal word emphasize the need for careful environmental protection measures during handling, storage, and disposal. Transportation falls under ADR Class 9 (miscellaneous dangerous substances), requiring appropriate documentation and packaging protocols. Industrial applications typically include pharmaceutical intermediate synthesis, where the indolinone core serves as a building block for bioactive compounds. The compound also finds use in specialty chemical manufacturing and research applications requiring chlorinated heterocyclic structures. Unlike simpler compounds such as copper(1+) thiocyanate, this molecule's complex structure makes it valuable for advanced synthetic transformations. The dual chlorine substitution pattern provides unique reactivity profiles for cross-coupling reactions and nucleophilic substitutions, making it particularly valuable in medicinal chemistry applications. Environmental monitoring and waste treatment protocols are essential due to its persistent aquatic toxicity profile. OYSI maintains reliable supply chains for this specialized compound, supporting pharmaceutical and chemical research industries across Europe.
Safety & Classification
Aquatic Acute 1; Aquatic Chronic 1
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Transport (ADR)
| UN Number | 3077 |
| ADR Class | 9 |
| Packing Group | III |
| Tunnel Code | - |
| Proper Shipping Name | 6-Chlor-5-(2-chlorethyl)-1,3-dihydroindol-2-on |
| Marine Pollutant | No |
Frequently Asked Questions
What is 6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one?
6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one is an organic chemical compound with the molecular formula C10H9Cl2NO and CAS number 118289-55-7. This chlorinated indole derivative has a molecular weight of 230.09 g/mol and contains two chlorine atoms in its structure. It is classified as hazardous to aquatic environments and requires proper handling and storage precautions in industrial applications.
What are the physicochemical properties of 6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one?
6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one is a solid organic compound with a molecular weight of 230.09 g/mol. As a chlorinated indole derivative, it contains two chlorine substituents that influence its chemical behavior and solubility characteristics. The compound's physical appearance, exact melting point, and solubility data would need to be confirmed through analytical testing or supplier documentation for specific applications.
What is 6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one used for?
6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one is primarily used as an intermediate in pharmaceutical synthesis and organic chemistry research. The compound's indole structure makes it valuable for developing pharmaceutical compounds, particularly those targeting neurological or biological pathways. Its chlorinated functional groups provide reactive sites for further chemical modifications in drug development and specialized chemical synthesis applications.
How to handle 6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one safely?
6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one requires standard laboratory safety precautions during handling. Wear appropriate personal protective equipment including safety goggles, chemical-resistant gloves, and protective clothing. Work in well-ventilated areas or under fume hoods to prevent inhalation. Given its aquatic toxicity classification (Aquatic Acute 1, Aquatic Chronic 1), prevent environmental release and ensure proper containment during use.
How to store 6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one correctly?
6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one should be stored in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep containers tightly sealed to prevent moisture absorption and contamination. Store away from oxidizing agents and strong bases that could react with the chlorinated structure. Maintain storage areas with appropriate spill containment measures due to its aquatic toxicity classification.
What to do in case of contact with 6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one?
In case of skin contact with 6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one, immediately wash the affected area with soap and plenty of water. For eye contact, rinse thoroughly with water for at least 15 minutes and seek medical attention. If inhaled, move to fresh air immediately. In case of ingestion, do not induce vomiting and seek medical attention promptly. Always consult the safety data sheet for detailed first aid procedures.
How to dispose of 6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one properly?
6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one must be disposed of as hazardous chemical waste through licensed waste disposal companies. Due to its aquatic toxicity classification, prevent release to water systems or soil. Follow local and national regulations for hazardous waste disposal. The compound cannot be disposed of through regular waste streams and requires incineration at appropriate high-temperature facilities equipped for chlorinated organic compounds.
How to transport 6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one?
6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one is classified under ADR Class 9 (Miscellaneous dangerous goods), Packing Group III. Transport requires appropriate UN-specification packaging and proper shipping documentation. The compound must be packaged to prevent leakage and labeled according to dangerous goods regulations. Carriers must be qualified for hazardous materials transport and follow ADR requirements for Class 9 substances during transportation.
Is 6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one subject to specific regulations?
6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one is subject to REACH regulation in Europe and requires registration for commercial use. The compound is classified under CLP regulation with GHS09 pictogram and 'Warning' signal word due to its aquatic toxicity. It is not currently listed as an SVHC (Substance of Very High Concern). Users must comply with occupational exposure limits and environmental protection requirements.
Where to buy 6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one in Europe?
6-chloro-5-(2-chloroethyl)-1,3-dihydroindol-2-one is available through OYSI, a specialized European distributor of fine chemicals and pharmaceutical intermediates. OYSI provides high-quality chemical products with proper documentation, safety data sheets, and regulatory compliance for European markets. Contact OYSI directly for availability, specifications, packaging options, and delivery arrangements for this specialized chemical compound across European countries.
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Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.