4-(1H-benzimidazol-2-yl)-1,3-thiazole
C10H7N3S
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Identification
- CAS Number
- 148-79-8
- EC Number
- 205-725-8
- UN Number
- 3077
- Index Number
- 613-054-00-0
- PubChem CID
- 5430
Physical-chemical properties
- Molecular Formula
- C10H7N3S
- Molar Mass
- 201.25 g/mol
- IUPAC Name
- 4-(1H-benzimidazol-2-yl)-1,3-thiazole
Chemical Identifiers
- InChI
- InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)
- InChI Key
- WJCNZQLZVWNLKY-UHFFFAOYSA-N
Overview
4-(1H-benzimidazol-2-yl)-1,3-thiazole (CAS 148-79-8) is a heterocyclic organic compound featuring both benzimidazole and thiazole ring systems with notable bioactive properties. This bicyclic compound represents an important class of nitrogen and sulfur-containing heterocycles widely utilized in pharmaceutical and chemical research applications. With its molecular formula C10H7N3S and molecular weight of 201.25 g/mol, this substance combines the structural features of benzimidazole and thiazole moieties, creating a versatile scaffold for various chemical modifications and applications. The compound exhibits significant environmental considerations, classified under Aquatic Acute 1 and Aquatic Chronic 1 hazard categories with GHS09 pictogram designation. These classifications indicate potential adverse effects on aquatic organisms and ecosystems, requiring careful handling and disposal protocols. The ADR Class 9 designation categorizes it as a miscellaneous dangerous substance for transportation purposes, necessitating appropriate packaging and documentation during shipping. In industrial applications, 4-(1H-benzimidazol-2-yl)-1,3-thiazole serves primarily as an intermediate in pharmaceutical synthesis, particularly in the development of antimicrobial and antifungal agents. The compound also finds use in agricultural chemical formulations and as a building block for specialty chemical production. Its structural similarity to other heterocyclic compounds used in coordination chemistry makes it valuable for developing metal complexes, though it differs significantly from simpler compounds like copper(1+) thiocyanate in terms of structural complexity and applications. Professional handling requires adherence to environmental protection measures due to its aquatic toxicity profile. The compound should be stored in appropriate conditions to maintain stability and prevent environmental release. OYSI provides technical-grade 4-(1H-benzimidazol-2-yl)-1,3-thiazole to qualified industrial customers across European markets with comprehensive safety documentation and regulatory compliance support.
Safety & Classification
Aquatic Acute 1; Aquatic Chronic 1
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Transport (ADR)
| UN Number | 3077 |
| ADR Class | 9 |
| Packing Group | III |
| Tunnel Code | - |
| Proper Shipping Name | Thiabendazol (ISO) |
| Marine Pollutant | No |
Frequently Asked Questions
What is 4-(1H-benzimidazol-2-yl)-1,3-thiazole?
4-(1H-benzimidazol-2-yl)-1,3-thiazole is an organic heterocyclic compound combining benzimidazole and thiazole ring systems. With the molecular formula C10H7N3S and CAS number 148-79-8, this compound has a molecular weight of 201.25 g/mol. It belongs to the class of nitrogen-sulfur containing heterocycles and is primarily recognized for its potential biological activities and research applications in pharmaceutical chemistry.
What are the physicochemical properties of 4-(1H-benzimidazol-2-yl)-1,3-thiazole?
4-(1H-benzimidazol-2-yl)-1,3-thiazole is a solid crystalline compound at room temperature with a molecular weight of 201.25 g/mol. The compound contains both nitrogen and sulfur heteroatoms within its fused ring system, which influences its solubility and stability characteristics. Specific physical properties such as melting point, solubility, and appearance may vary depending on purity and crystalline form, requiring consultation of detailed technical specifications.
What is 4-(1H-benzimidazol-2-yl)-1,3-thiazole used for?
4-(1H-benzimidazol-2-yl)-1,3-thiazole is primarily used in pharmaceutical research and development as a building block for bioactive compounds. Its unique heterocyclic structure makes it valuable in medicinal chemistry for developing potential therapeutic agents. The compound may also serve as an intermediate in organic synthesis and as a research tool in academic and industrial laboratories studying heterocyclic chemistry and drug discovery applications.
How to handle 4-(1H-benzimidazol-2-yl)-1,3-thiazole safely?
4-(1H-benzimidazol-2-yl)-1,3-thiazole requires careful handling due to its aquatic toxicity classification. Always wear appropriate personal protective equipment including safety glasses, gloves, and lab coats. Work in well-ventilated areas or under fume hoods to avoid inhalation. Prevent release to the environment and avoid contact with skin and eyes. Follow standard laboratory safety protocols and ensure proper training before handling this compound.
How to store 4-(1H-benzimidazol-2-yl)-1,3-thiazole correctly?
4-(1H-benzimidazol-2-yl)-1,3-thiazole should be stored in tightly sealed containers in a cool, dry place away from direct sunlight and heat sources. Keep the compound in its original packaging with proper labeling including hazard warnings. Store separately from incompatible materials and ensure adequate ventilation in storage areas. Implement measures to prevent environmental release and maintain inventory records for regulatory compliance.
What to do in case of contact with 4-(1H-benzimidazol-2-yl)-1,3-thiazole?
In case of skin contact with 4-(1H-benzimidazol-2-yl)-1,3-thiazole, immediately wash the affected area with plenty of water and soap for at least 15 minutes. If eye contact occurs, rinse thoroughly with clean water for several minutes and remove contact lenses if present. In case of inhalation, move to fresh air immediately. Seek medical attention if irritation persists or if large amounts were involved. Keep the safety data sheet available for medical personnel.
How to dispose of 4-(1H-benzimidazol-2-yl)-1,3-thiazole appropriately?
4-(1H-benzimidazol-2-yl)-1,3-thiazole must be disposed of through licensed hazardous waste disposal facilities due to its aquatic toxicity classification. Never discharge to sewers, waterways, or soil. Collect waste in properly labeled containers and arrange disposal through authorized waste management companies. Follow local, national, and EU waste regulations including the Waste Framework Directive. Maintain disposal records for regulatory compliance and traceability.
How to transport 4-(1H-benzimidazol-2-yl)-1,3-thiazole?
4-(1H-benzimidazol-2-yl)-1,3-thiazole is classified as ADR Class 9 (Miscellaneous dangerous goods), Packing Group III for transport purposes. This classification requires specific packaging, labeling, and documentation according to ADR regulations. Use approved packaging materials and ensure proper hazard labeling including the GHS09 pictogram. Transport documentation must include the correct shipping name, UN number, and emergency response information. Comply with all applicable transport regulations.
Is 4-(1H-benzimidazol-2-yl)-1,3-thiazole subject to specific regulations?
4-(1H-benzimidazol-2-yl)-1,3-thiazole is subject to EU REACH and CLP regulations but is not currently listed as a Substance of Very High Concern (SVHC). The compound requires classification as Aquatic Acute 1 and Aquatic Chronic 1 with Warning signal word and GHS09 pictogram. Users must comply with safety data sheet requirements, proper labeling, and environmental protection measures. Regular regulatory updates should be monitored for any changes in classification or restrictions.
Where to buy 4-(1H-benzimidazol-2-yl)-1,3-thiazole in Europe?
4-(1H-benzimidazol-2-yl)-1,3-thiazole is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides this compound with full regulatory compliance including proper classification, labeling, and safety documentation. As an established European supplier, OYSI ensures quality standards and regulatory adherence for professional and research applications. Contact OYSI directly for specific availability, technical specifications, and ordering information for your requirements.
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Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.