6-amino-N-methylnaphthalene-2-sulfonamide

C11H12N2O2S

CAS104295-55-8
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
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Identification

CAS Number
104295-55-8
EC Number
412-120-4
UN Number
3077
Index Number
612-177-00-7
PubChem CID
3034961

Physical-chemical properties

Molecular Formula
C11H12N2O2S
Molar Mass
236.29 g/mol
IUPAC Name
6-amino-N-methylnaphthalene-2-sulfonamide

Chemical Identifiers

InChI
InChI=1S/C11H12N2O2S/c1-13-16(14,15)11-5-3-8-6-10(12)4-2-9(8)7-11/h2-7,13H,12H2,1H3
InChI Key
RBQODZRXIYFUJS-UHFFFAOYSA-N

Overview

6-amino-N-methylnaphthalene-2-sulfonamide (CAS 104295-55-8) is an aromatic sulfonamide compound with amino and methylamino functional groups. This specialized chemical intermediate belongs to the naphthalene sulfonamide family and serves important roles in various industrial applications requiring specific structural characteristics. With the molecular formula C11H12N2O2S and a molecular weight of 236.29 g/mol, this compound features a naphthalene backbone substituted with both amino and N-methylsulfonamide groups, providing unique chemical reactivity patterns. The EC number 412-120-4 identifies this substance within European chemical regulations, while its classification under ADR Class 9 indicates specific transport considerations for miscellaneous dangerous goods. From a safety perspective, 6-amino-N-methylnaphthalene-2-sulfonamide requires careful handling due to its classification as STOT RE 2 (specific target organ toxicity through repeated exposure), Skin Sens. 1 (skin sensitizer), and Aquatic Chronic 2 (chronic aquatic toxicity). The associated GHS pictograms GHS08, GHS07, and GHS09 with warning signal word emphasize the need for appropriate personal protective equipment and environmental precautions during handling and storage. Industrial applications typically include use as a chemical intermediate in pharmaceutical synthesis, dye manufacturing, and specialty chemical production. The compound's structural similarity to other aromatic systems makes it valuable in developing products where naphthalene-based chemistry is required, though distinct from simpler aromatic compounds like 1,4-dichlorobenzene which serves different industrial purposes. Quality chemical intermediates like 6-amino-N-methylnaphthalene-2-sulfonamide are available through OYSI's European distribution network, supporting manufacturers requiring reliable access to specialized aromatic sulfonamide compounds for their production processes.

Safety & Classification

Warning
Classification:

STOT RE 2 *; Skin Sens. 1; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H373

May cause damage to organs through prolonged or repeated exposure.

H317

May cause an allergic skin reaction.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3077
ADR Class9
Packing GroupIII
Tunnel Code-
Proper Shipping Name6-Amino-N-methylnaphthalin-2-sulfonamid
Marine PollutantNo

Frequently Asked Questions

What is 6-amino-N-methylnaphthalene-2-sulfonamide?

6-amino-N-methylnaphthalene-2-sulfonamide is an organic chemical compound with the molecular formula C11H12N2O2S and CAS number 104295-55-8. This sulfonamide derivative features both amino and methylamide functional groups attached to a naphthalene ring system. With a molecular weight of 236.29 g/mol, it is classified as a hazardous substance requiring careful handling due to its potential for skin sensitization and specific target organ toxicity.

What are the physicochemical properties of 6-amino-N-methylnaphthalene-2-sulfonamide?

6-amino-N-methylnaphthalene-2-sulfonamide is a solid organic compound at room temperature, typically appearing as a crystalline powder. The presence of both amino and sulfonamide groups suggests moderate polarity and potential water solubility. Its naphthalene backbone provides aromatic stability and influences its physical characteristics. Specific melting point, boiling point, and solubility data should be consulted from technical specifications for precise handling requirements.

What is 6-amino-N-methylnaphthalene-2-sulfonamide used for?

6-amino-N-methylnaphthalene-2-sulfonamide serves primarily as an intermediate in pharmaceutical and chemical synthesis processes. Its sulfonamide structure makes it valuable for developing pharmaceutical compounds, particularly in medicinal chemistry applications. The compound may also be used in research and development activities, specialty chemical manufacturing, and as a building block for more complex organic molecules in various industrial applications requiring specific aromatic sulfonamide functionality.

How to handle 6-amino-N-methylnaphthalene-2-sulfonamide safely?

Safe handling of 6-amino-N-methylnaphthalene-2-sulfonamide requires appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing to prevent skin contact and sensitization. Work should be conducted in well-ventilated areas or under fume hoods to minimize inhalation exposure. Given its STOT RE 2 classification, avoid repeated or prolonged exposure. Always wash hands thoroughly after handling and follow good industrial hygiene practices.

How to store 6-amino-N-methylnaphthalene-2-sulfonamide correctly?

6-amino-N-methylnaphthalene-2-sulfonamide should be stored in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Keep containers tightly closed when not in use to prevent moisture absorption and contamination. Store separately from incompatible materials such as strong oxidizing agents. Ensure storage areas are equipped with appropriate spill containment measures and maintain temperatures within recommended ranges specified in the technical documentation.

What to do in case of contact with 6-amino-N-methylnaphthalene-2-sulfonamide?

In case of skin contact with 6-amino-N-methylnaphthalene-2-sulfonamide, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. If eye contact occurs, flush immediately with clean water for 15 minutes while holding eyelids open. For inhalation exposure, move to fresh air immediately. Given its skin sensitization potential, seek medical attention if irritation persists or allergic reactions develop.

How to dispose of 6-amino-N-methylnaphthalene-2-sulfonamide appropriately?

6-amino-N-methylnaphthalene-2-sulfonamide must be disposed of as hazardous chemical waste in accordance with local, national, and EU regulations. Contact licensed waste disposal companies specializing in chemical waste management. Never dispose of this substance down drains, in regular waste, or release to the environment due to its aquatic toxicity classification. Ensure waste containers are properly labeled and documented following waste tracking requirements.

How to transport 6-amino-N-methylnaphthalene-2-sulfonamide?

6-amino-N-methylnaphthalene-2-sulfonamide is classified as ADR Class 9 (Miscellaneous dangerous substances), Packing Group III, indicating it requires special transport considerations. Packages must be properly labeled with appropriate hazard markings and documentation. Use approved packaging materials and ensure compliance with ADR regulations for road transport within Europe. Consult transport regulations for specific requirements regarding quantity limitations, vehicle requirements, and driver training certifications.

Is 6-amino-N-methylnaphthalene-2-sulfonamide subject to specific regulations?

6-amino-N-methylnaphthalene-2-sulfonamide is subject to EU CLP regulation due to its hazard classifications (STOT RE 2, Skin Sens. 1, Aquatic Chronic 2) and REACH regulation for chemical registration and safety data. While not currently listed as an SVHC substance, it requires safety data sheets, proper labeling with GHS pictograms (GHS07, GHS08, GHS09), and adherence to occupational exposure limits where established.

Where to buy 6-amino-N-methylnaphthalene-2-sulfonamide in Europe?

6-amino-N-methylnaphthalene-2-sulfonamide is available through OYSI, a leading European distributor of specialty chemicals. OYSI provides high-quality chemical products with comprehensive technical support and regulatory compliance documentation. As an established European supplier, OYSI ensures proper handling, storage, and transport of hazardous chemicals while maintaining industry standards for customer service and product quality throughout Europe.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.