4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine

C9H5Cl3N4

CAS101-05-3
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
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Identification

CAS Number
101-05-3
EC Number
202-910-5
UN Number
3077
Index Number
613-053-00-5
PubChem CID
7541

Physical-chemical properties

Molecular Formula
C9H5Cl3N4
Molar Mass
275.50 g/mol
IUPAC Name
4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine

Chemical Identifiers

InChI
InChI=1S/C9H5Cl3N4/c10-5-3-1-2-4-6(5)13-9-15-7(11)14-8(12)16-9/h1-4H,(H,13,14,15,16)
InChI Key
IMHBYKMAHXWHRP-UHFFFAOYSA-N

Overview

4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine (CAS 101-05-3) is a chlorinated triazine derivative with selective herbicidal activity and pharmaceutical intermediate properties. This organochlorine compound, also known by its CAS number 101-05-3, represents an important class of triazine-based chemicals characterized by its symmetric heterocyclic structure containing three nitrogen atoms and multiple chlorine substituents. With a molecular formula of C9H5Cl3N4 and molecular weight of 275.5 g/mol, this white to off-white crystalline solid demonstrates moderate stability under normal conditions while requiring careful handling due to its classification as a skin and eye irritant. The compound's triazine core structure provides excellent thermal stability and chemical resistance, making it valuable in various synthetic applications. Its three chlorine atoms contribute to its biological activity and serve as reactive sites for further chemical modifications. Safety considerations are paramount when handling this material, as it carries GHS07 and GHS09 pictograms, indicating potential for skin and eye irritation as well as environmental hazards, particularly to aquatic organisms where it shows both acute and chronic toxicity. Primary industrial applications include its use as an intermediate in pharmaceutical synthesis, particularly in the development of antimicrobial agents, and as a building block for advanced herbicide formulations. The compound also finds application in specialty chemical manufacturing where selective chlorination patterns are required. Similar to other chlorinated compounds like 2,3,5,6-tetrachlorocyclohexa-2,5-diene-1,4-dione, it requires specialized handling protocols and environmental monitoring. OYSI maintains reliable supply chains for 4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine, ensuring consistent availability for European industrial customers requiring this specialized chemical intermediate.

Safety & Classification

Warning
Classification:

Skin Irrit. 2; Eye Irrit. 2; Aquatic Acute 1; Aquatic Chronic 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H315

Causes skin irritation.

H319

Causes serious eye irritation.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Irritant

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3077
ADR Class9
Packing GroupIII
Tunnel Code-
Proper Shipping NameAnilazin (ISO)
Marine PollutantNo

Frequently Asked Questions

What is 4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine?

4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine is a chlorinated triazine derivative with the molecular formula C9H5Cl3N4 and CAS number 101-05-3. This chemical compound has a molecular weight of 275.5 g/mol and belongs to the family of substituted triazines. It is classified as a hazardous substance due to its potential for skin and eye irritation, as well as its environmental toxicity to aquatic organisms.

What are the physicochemical properties of 4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine?

4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine is a solid crystalline compound at room temperature with a molecular weight of 275.5 g/mol. The substance contains three chlorine atoms in its structure, contributing to its chemical stability and specific reactivity patterns. Its triazine ring structure provides characteristic chemical properties typical of this class of compounds, including resistance to hydrolysis under normal conditions and specific binding capabilities.

What is 4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine used for?

4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine is primarily used as a chemical intermediate in pharmaceutical and agrochemical synthesis. The compound serves as a building block for the production of various active pharmaceutical ingredients and crop protection agents. Its triazine structure makes it valuable in the development of herbicides, fungicides, and other specialty chemicals where nitrogen-containing heterocyclic compounds are required for biological activity.

How to handle 4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine safely?

Safe handling of 4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine requires appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid direct skin and eye contact due to its irritant properties. Ensure proper training of personnel on chemical hazards and emergency procedures before handling this substance.

How to store 4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine correctly?

4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine should be stored in a cool, dry, well-ventilated area away from incompatible materials. Keep containers tightly closed and protected from moisture and direct sunlight. Store separately from strong bases, oxidizing agents, and reducing agents to prevent unwanted reactions. Ensure storage areas are equipped with appropriate spill containment measures and maintain inventory records according to local chemical storage regulations.

What to do in case of contact with 4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine?

In case of skin contact with 4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine, immediately wash the affected area with plenty of soap and water for at least 15 minutes. For eye contact, rinse thoroughly with clean water for at least 15 minutes and seek immediate medical attention. If inhaled, move the person to fresh air and monitor breathing. Remove contaminated clothing and seek medical advice if irritation persists or if large amounts were involved.

How to dispose of 4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine properly?

Disposal of 4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine must be conducted through licensed hazardous waste disposal facilities in accordance with local and European waste regulations. The substance cannot be disposed of in regular waste streams due to its classification as hazardous to aquatic environments. Contact certified waste management companies for proper collection, treatment, and disposal. Ensure all disposal activities comply with REACH and national chemical waste legislation.

How to transport 4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine?

4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine is classified as ADR Class 9 (Miscellaneous dangerous goods), Packing Group III for transportation purposes. This classification requires appropriate packaging, labeling, and documentation according to international dangerous goods regulations. Transport vehicles must carry proper placarding and emergency response information. Ensure compliance with ADR requirements for packaging specifications, quantity limitations, and driver certification for hazardous materials transport.

Is 4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine subject to specific regulations?

4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine is subject to European REACH regulation requiring registration and compliance with chemical safety requirements. The substance is classified under CLP regulation with GHS07 and GHS09 pictograms and 'Warning' signal word. It is not currently listed as a Substance of Very High Concern (SVHC). Users must comply with safety data sheet requirements, exposure scenario guidelines, and downstream user obligations under REACH.

Where to buy 4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine in Europe?

4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazin-2-amine is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides reliable supply chains for research institutions, pharmaceutical companies, and chemical manufacturers across Europe. As an established chemical distributor, OYSI ensures proper documentation, regulatory compliance, and quality assurance for all supplied materials. Contact OYSI directly for availability, specifications, and technical support for your specific applications.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.