4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one
C19H16O3
Consulting for 4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one
Our experts support you with application, dosage, and compliance.
Identification
- CAS Number
- 5836-29-3
- EC Number
- 227-424-0
- UN Number
- 3027
- Index Number
- 607-059-00-7
- PubChem CID
- 54678504
Physical-chemical properties
- Molecular Formula
- C19H16O3
- Molar Mass
- 292.30 g/mol
- IUPAC Name
- 4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one
Chemical Identifiers
- InChI
- InChI=1S/C19H16O3/c20-18-15-9-3-4-11-16(15)22-19(21)17(18)14-10-5-7-12-6-1-2-8-13(12)14/h1-4,6,8-9,11,14,20H,5,7,10H2
- InChI Key
- ULSLJYXHZDTLQK-UHFFFAOYSA-N
Overview
4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one (CAS 5836-29-3) is a synthetic coumarin derivative with potent anticoagulant properties and significant toxicological concerns. This complex organic compound belongs to the hydroxycoumarin family and represents a structurally sophisticated anticoagulant agent with a molecular formula of C19H16O3 and molecular weight of 292.3 g/mol. The substance features a chromen-2-one core structure substituted with a hydroxyl group and a tetrahydronaphthalene moiety, which contributes to its biological activity and chemical stability. Due to its structural complexity, this compound requires careful handling and specialized storage conditions to maintain its integrity and prevent degradation. The safety profile of this substance demands particular attention, as it carries multiple severe hazard classifications including reproductive toxicity category 1B, acute toxicity categories 2 and 3, specific target organ toxicity with repeated exposure category 1, and chronic aquatic toxicity category 1. These classifications necessitate the use of GHS pictograms GHS08, GHS06, and GHS09, with "Danger" as the signal word. Transportation falls under ADR class 6.1, reflecting its toxic nature. Unlike simpler aromatic compounds such as N-methylaniline, this coumarin derivative presents more complex toxicological challenges due to its specific mechanism of action on blood coagulation pathways. Primary industrial applications include pharmaceutical research for anticoagulant drug development, biochemical studies of blood coagulation mechanisms, and specialized analytical chemistry applications. The compound also finds use in toxicological research and as a reference standard in analytical laboratories studying coumarin-based substances. OYSI provides this specialized coumarin derivative to qualified industrial customers with appropriate handling capabilities and regulatory compliance requirements.
Safety & Classification
Repr. 1B; Acute Tox. 2; Acute Tox. 3; Acute Tox. 2; STOT RE 1; Aquatic Chronic 1
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Inhalation
Measures if vapours or dust are inhaled
First Aid Actions
- +P304IF INHALED:
- +P340Remove person to fresh air and keep comfortable for breathing.
- +P311Call a POISON CENTER/doctor.
Related hazard statements:
Skin Contact
Measures if substance contacts the skin
First Aid Actions
- +P302IF ON SKIN:
- +P352Wash with plenty of water.
- +P361Take off immediately all contaminated clothing.
- +P313Get medical advice/attention.
Related hazard statements:
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 3027 |
| ADR Class | 6.1 |
| Packing Group | I |
| Tunnel Code | C/E |
| Proper Shipping Name | Coumatetralyl (ISO) |
| Marine Pollutant | No |
Frequently Asked Questions
What is 4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one?
4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one is an organic chemical compound with the molecular formula C19H16O3 and CAS number 5836-29-3. This chromenone derivative has a molecular weight of 292.3 g/mol and features a complex structure combining a chromen-2-one backbone with a tetrahydronaphthalene substituent. The compound is classified as highly hazardous with reproductive toxicity, acute toxicity, and organ toxicity properties.
What are the physicochemical properties of 4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one?
4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one is a solid organic compound with a molecular weight of 292.3 g/mol and molecular formula C19H16O3. As a chromenone derivative, it contains aromatic ring systems that typically confer stability and specific solubility characteristics. The presence of the hydroxyl group suggests potential for hydrogen bonding, influencing its physical properties and interactions with solvents.
What is 4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one used for?
4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one is primarily used in specialized chemical research and pharmaceutical applications. Its chromenone structure makes it valuable as an intermediate in organic synthesis and potentially in the development of bioactive compounds. Given its complex aromatic structure, it may serve as a building block for creating more sophisticated molecules in medicinal chemistry and advanced materials research.
How to handle 4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one safely?
4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one requires extreme caution due to its Danger signal word and multiple acute toxicity classifications. Essential PPE includes chemical-resistant gloves, safety goggles, and respiratory protection. Work must be conducted in well-ventilated areas or under fume hoods. Avoid skin contact, inhalation, and ingestion. The compound's reproductive toxicity (Repr. 1B) and organ toxicity (STOT RE 1) classifications demand strict adherence to safety protocols.
How to store 4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one correctly?
4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one must be stored in a secure, well-ventilated area away from heat sources and incompatible materials. Given its ADR Class 6.1 Group I classification, it requires high-security storage conditions. Keep containers tightly sealed, properly labeled, and accessible only to trained personnel. Storage areas should have appropriate containment systems and emergency equipment. Regular inventory and condition checks are essential for safe storage management.
What to do in case of contact with 4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one?
Immediate action is critical following contact with 4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one due to its Acute Tox. 2 and 3 classifications. For skin contact, remove contaminated clothing and rinse thoroughly with water for at least 15 minutes. If inhaled, move to fresh air immediately. For eye contact, flush with water continuously. Seek immediate medical attention in all cases, providing the safety data sheet to medical personnel.
How to dispose of 4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one properly?
4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one requires disposal as hazardous waste through licensed waste management facilities due to its multiple hazard classifications including aquatic chronic toxicity. Never dispose of in regular waste streams or pour down drains. Waste must be properly containerized, labeled, and documented according to local and EU waste regulations. Contact certified hazardous waste disposal companies for collection and treatment.
How to transport 4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one?
4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one is classified as ADR Class 6.1, Packing Group I, indicating highly toxic substances requiring stringent transport regulations. Packaging must meet UN specifications for Group I dangerous goods. Vehicles must display appropriate hazard placards, and drivers require ADR certification. Transport documentation must include proper shipping names, hazard classes, and emergency response information. Only authorized carriers can handle this high-risk material.
Is 4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one subject to special regulations?
4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one is subject to comprehensive EU chemical regulations under REACH and CLP frameworks. Its multiple hazard classifications (Repr. 1B, Acute Tox. 2/3, STOT RE 1) trigger strict handling, labeling, and reporting requirements. While not currently listed as SVHC, its high toxicity profile may result in use restrictions or authorization requirements. Companies must maintain detailed exposure scenarios and implement appropriate risk management measures.
Where to buy 4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one in Europe?
4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one is available through OYSI, a specialized European distributor of fine chemicals and pharmaceutical intermediates. As a professional chemical supplier, OYSI ensures proper documentation, packaging, and regulatory compliance for this highly regulated substance. Given the compound's complex hazard profile and transport requirements, working with experienced distributors like OYSI ensures safe, compliant procurement and delivery across Europe.
Services for 4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one
Order 4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one
Fast delivery across Europe
SDS Service
Request Safety Data Sheet for 4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one
Technical Consulting
Application advice for 4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one
REACH Safety Data Sheet
REACH Compliance Service
Digital Product Passport
EU-compliant product documentation
ADR Consulting for 4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one
4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one is a dangerous good. We support you with labeling, packaging, and transport documentation.
Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.