4-bromo-2-chloro-1-fluorobenzene

4-bromo-2-chloro-1-fluorobenzene is a trihalogenated aromatic compound with the molecular formula C6H3BrClF and CAS number 60811-21-4. This benzene derivative contains three different halogen substituents (bromine, chlorine, and fluorine) positioned at the 4-, 2-, and 1- positions respectively. With a molecular weight of 209.44 g/mol, it serves as an important intermediate in organic synthesis and pharmaceutical manufacturing.

4-bromo-2-chloro-1-fluorobenzene is typically a colorless to pale yellow liquid or solid at room temperature, depending on purity and storage conditions. As a halogenated aromatic compound, it exhibits low water solubility but good solubility in organic solvents such as alcohols, ethers, and hydrocarbons. The presence of multiple halogens contributes to its relatively high molecular weight and influences its volatility and chemical reactivity.

4-bromo-2-chloro-1-fluorobenzene is primarily used as a chemical intermediate in pharmaceutical synthesis and fine chemical manufacturing. Its unique halogenation pattern makes it valuable for producing complex organic molecules through cross-coupling reactions, nucleophilic substitutions, and other synthetic transformations. The compound is particularly useful in medicinal chemistry for developing drug candidates and in the production of specialty chemicals requiring specific halogen arrangements.

4-bromo-2-chloro-1-fluorobenzene requires careful handling due to its Acute Tox. 4 and Skin Irrit. 2 classifications. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing to prevent skin and eye contact. Work should be conducted in well-ventilated areas or under fume hoods to minimize inhalation exposure. The Warning signal word indicates moderate hazard levels requiring standard laboratory safety protocols.

4-bromo-2-chloro-1-fluorobenzene should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from direct sunlight and heat sources. As a halogenated compound, it should be kept separate from strong bases, metals, and reducing agents to prevent unwanted reactions. Storage areas should be equipped with appropriate spill containment measures and maintained at stable temperatures to preserve product integrity and minimize degradation.

Immediate action is required following contact with 4-bromo-2-chloro-1-fluorobenzene due to its skin irritant properties. For skin contact, remove contaminated clothing and rinse the affected area with plenty of water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15 minutes and seek medical attention. If inhaled, move the person to fresh air and monitor breathing. Seek medical advice if symptoms persist or worsen.

4-bromo-2-chloro-1-fluorobenzene must be disposed of as hazardous waste through licensed waste management companies due to its toxicity and environmental hazard classifications (Aquatic Acute 1, Aquatic Chronic 1). The compound cannot be disposed of in regular waste streams or sewage systems. Disposal methods typically include high-temperature incineration at authorized facilities. Always consult local environmental regulations and waste disposal authorities for specific requirements in your jurisdiction.

4-bromo-2-chloro-1-fluorobenzene is classified as ADR Class 9 (Miscellaneous dangerous goods), Packing Group III for transportation purposes. This classification requires appropriate packaging, labeling, and documentation according to international dangerous goods regulations. Transport containers must be properly sealed, labeled with hazard markings, and accompanied by safety data sheets. Professional carriers experienced in handling chemical substances should be used to ensure regulatory compliance and safe delivery.

4-bromo-2-chloro-1-fluorobenzene is subject to standard European chemical regulations including REACH registration requirements and CLP classification obligations. The compound is not currently identified as a Substance of Very High Concern (SVHC). Users must comply with occupational safety regulations, environmental protection laws, and proper chemical handling protocols. Import/export activities may require additional documentation and permits depending on quantities and destinations involved.

4-bromo-2-chloro-1-fluorobenzene is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides reliable supply chains across European markets with proper regulatory documentation and quality assurance. As a professional chemical distributor, OYSI ensures compliance with all relevant safety and transportation regulations while maintaining product quality standards for laboratory and industrial applications throughout Europe.