4-bromo-2-chloro-1-fluorobenzene

4-bromo-2-chloro-1-fluorobenzene is a halogenated aromatic compound with the molecular formula C6H3BrClF and CAS number 60811-21-4. This chemical features a benzene ring substituted with three different halogens: bromine at position 4, chlorine at position 2, and fluorine at position 1. With a molecular weight of 209.44 g/mol, it belongs to the class of polyhalogenated benzenes used primarily as synthetic intermediates in organic chemistry and pharmaceutical manufacturing.

4-bromo-2-chloro-1-fluorobenzene is typically a colorless to pale yellow liquid at room temperature with a characteristic aromatic odor. As a halogenated aromatic compound, it exhibits low water solubility but good solubility in organic solvents such as alcohols, ethers, and hydrocarbons. The presence of three different halogens influences its boiling point, density, and reactivity patterns, making it a valuable intermediate for selective chemical transformations in organic synthesis.

4-bromo-2-chloro-1-fluorobenzene serves primarily as a synthetic intermediate in pharmaceutical and agrochemical industries. Its multiple halogen substituents make it valuable for cross-coupling reactions, nucleophilic substitutions, and other organic transformations. The compound is commonly used in the synthesis of complex molecules where selective halogen replacement is required. It also finds applications in the production of specialty chemicals, dyes, and advanced materials where specific substitution patterns are essential for desired properties.

4-bromo-2-chloro-1-fluorobenzene requires careful handling due to its Acute Tox. 4 and Skin Irrit. 2 classifications. Always wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods to avoid inhalation. Prevent skin and eye contact, and avoid ingestion. Use proper handling techniques to minimize spills and exposure. Emergency eyewash stations and safety showers should be readily accessible when working with this substance.

4-bromo-2-chloro-1-fluorobenzene should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Keep containers in secondary containment to prevent environmental release, as the compound is classified as Aquatic Acute 1 and Aquatic Chronic 1. Store away from incompatible materials such as strong oxidizers, bases, and metals. Maintain storage temperatures below 25°C and ensure proper labeling with GHS07 and GHS09 pictograms for identification.

In case of skin contact with 4-bromo-2-chloro-1-fluorobenzene, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, rinse immediately with clean water for 15 minutes, holding eyelids open. If inhaled, move the person to fresh air and seek medical attention if breathing difficulties occur. In case of ingestion, do not induce vomiting and seek immediate medical attention. Always consult the safety data sheet for complete first aid procedures.

4-bromo-2-chloro-1-fluorobenzene must be disposed of as hazardous waste through licensed waste management companies due to its toxicity and environmental hazard classifications. The compound cannot be discharged to sewers or the environment given its Aquatic Acute 1 and Aquatic Chronic 1 classifications. Collect waste in appropriate containers, label clearly, and maintain waste manifests as required by local regulations. Incineration at high temperatures in specialized facilities is typically the preferred disposal method for halogenated organic compounds.

4-bromo-2-chloro-1-fluorobenzene is classified as ADR Class 9 (Miscellaneous dangerous goods), Packing Group III for transportation purposes. This classification requires appropriate packaging, labeling with Class 9 hazard labels, and proper shipping documentation. Containers must meet UN packaging specifications and be properly sealed to prevent leakage. Transport vehicles should carry appropriate emergency equipment and drivers must have ADR training certification. Ensure compliance with all applicable transport regulations including proper shipping names and UN identification numbers.

4-bromo-2-chloro-1-fluorobenzene is subject to REACH regulation requiring registration for manufacture or import above one tonne per year in the EU. The compound is not currently listed as a Substance of Very High Concern (SVHC). It must be classified and labeled according to CLP regulation with Warning signal word and GHS07/GHS09 pictograms. Users must comply with occupational exposure limits, environmental discharge restrictions, and waste management regulations. Safety data sheets must be provided to downstream users as required by chemical legislation.

4-bromo-2-chloro-1-fluorobenzene is available through OYSI, a specialized European distributor of high-quality chemical products. OYSI provides reliable supply chains across Europe with proper documentation, safety data sheets, and regulatory compliance support. As an established chemical distributor, OYSI ensures product quality, appropriate packaging, and adherence to transport regulations. Contact OYSI directly for availability, specifications, and delivery options to your location within Europe. Professional technical support is available to assist with product selection and application guidance.