4-amino-2-(aminomethyl)phenol;dihydrochloride

C7H12Cl2N2O

CAS135043-64-0
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
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Identification

CAS Number
135043-64-0
EC Number
412-510-4
UN Number
3077
Index Number
612-189-00-2
PubChem CID
5463812

Physical-chemical properties

Molecular Formula
C7H12Cl2N2O
Molar Mass
211.09 g/mol
IUPAC Name
4-amino-2-(aminomethyl)phenol;dihydrochloride

Chemical Identifiers

InChI
InChI=1S/C7H10N2O.2ClH/c8-4-5-3-6(9)1-2-7(5)10;;/h1-3,10H,4,8-9H2;2*1H
InChI Key
KNHWFUNNXGJVOZ-UHFFFAOYSA-N

Overview

4-amino-2-(aminomethyl)phenol dihydrochloride (CAS 135043-64-0) is an aminophenol derivative with dual amino functionality and enhanced water solubility. This dihydrochloride salt represents a specialized aminophenol compound featuring both primary amine and phenolic hydroxyl groups, providing unique chemical reactivity for various industrial applications. With the molecular formula C7H12Cl2N2O and a molecular mass of 211.09 g/mol, this compound exhibits enhanced solubility characteristics compared to its free base form due to the presence of two hydrochloride groups. The dual amino functionality distinguishes it from simpler aminophenol compounds, offering multiple reactive sites for chemical transformations. The compound presents moderate toxicity concerns with Acute Tox. 4 classification and skin sensitization potential (Skin Sens. 1), requiring appropriate handling protocols in industrial settings. Environmental considerations are significant due to its Aquatic Acute 1 and Aquatic Chronic 1 classifications, indicating potential harmful effects on aquatic ecosystems. The GHS07 and GHS09 pictograms reflect these health and environmental hazards, while the ADR Class 9 designation categorizes it as a miscellaneous dangerous substance for transport purposes. Primary applications include use as an intermediate in pharmaceutical synthesis, where the dual amino functionality enables complex molecular construction. The compound also finds utility in specialty polymer chemistry and as a building block for advanced materials applications. Its structural similarity to other phenolic compounds such as 1-N-phenyl-4-N-propan-2-ylbenzene-1,4-diamine highlights its position within the broader aminophenol chemical family, though its unique aminomethyl substitution pattern provides distinct reactivity profiles. OYSI maintains reliable supply chains for 4-amino-2-(aminomethyl)phenol dihydrochloride to support European industrial customers requiring consistent quality and technical support for their specialized chemical processes.

Safety & Classification

Warning
Classification:

Acute Tox. 4 *; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H302

Harmful if swallowed.

H317

May cause an allergic skin reaction.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3077
ADR Class9
Packing GroupIII
Tunnel Code-
Proper Shipping Name4-Amino-2-(aminomethyl)phenol-dihydrochlorid
Marine PollutantNo

Frequently Asked Questions

What is 4-amino-2-(aminomethyl)phenol;dihydrochloride?

4-amino-2-(aminomethyl)phenol;dihydrochloride is an organic chemical compound with the molecular formula C7H12Cl2N2O and CAS number 135043-64-0. This dihydrochloride salt features a phenol ring substituted with amino groups, making it a versatile building block in chemical synthesis. With a molecular weight of 211.09 g/mol, it belongs to the class of aminophenol derivatives commonly used in pharmaceutical and chemical industries.

What are the physicochemical properties of 4-amino-2-(aminomethyl)phenol;dihydrochloride?

4-amino-2-(aminomethyl)phenol;dihydrochloride typically appears as a crystalline solid at room temperature due to its dihydrochloride salt form. The presence of multiple amino groups and the phenolic hydroxyl group suggests good water solubility, which is enhanced by the hydrochloride salt formation. The compound's molecular structure indicates potential for hydrogen bonding, affecting its melting point and dissolution characteristics in polar solvents.

What is 4-amino-2-(aminomethyl)phenol;dihydrochloride used for?

4-amino-2-(aminomethyl)phenol;dihydrochloride serves as an important intermediate in pharmaceutical synthesis and chemical manufacturing processes. Its dual amino functionality makes it valuable for creating complex molecular structures through condensation and coupling reactions. The compound is commonly utilized in the production of dyes, pharmaceuticals, and specialized chemical compounds where aminophenol derivatives are required as building blocks.

How to handle 4-amino-2-(aminomethyl)phenol;dihydrochloride safely?

4-amino-2-(aminomethyl)phenol;dihydrochloride requires careful handling due to its Acute Tox. 4 and Skin Sens. 1 classifications. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and appropriate respiratory protection. Work should be conducted in well-ventilated areas or under fume hoods to minimize inhalation exposure. Avoid direct skin contact and ensure immediate washing if contact occurs, as the compound may cause sensitization reactions.

How to store 4-amino-2-(aminomethyl)phenol;dihydrochloride correctly?

4-amino-2-(aminomethyl)phenol;dihydrochloride should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from direct sunlight. Due to its amino and phenolic groups, protect from oxidizing agents and strong acids or bases that could cause degradation. Maintain storage temperatures below 25°C when possible and ensure containers are properly labeled with hazard information. Keep away from incompatible materials to prevent unwanted reactions.

What to do in case of contact with 4-amino-2-(aminomethyl)phenol;dihydrochloride?

Immediate first aid for 4-amino-2-(aminomethyl)phenol;dihydrochloride exposure involves thorough decontamination. For skin contact, remove contaminated clothing and wash affected areas with plenty of water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15-20 minutes and remove contact lenses if present. If inhaled, move to fresh air immediately. Seek medical attention promptly, especially given the compound's sensitization potential.

How to dispose of 4-amino-2-(aminomethyl)phenol;dihydrochloride properly?

4-amino-2-(aminomethyl)phenol;dihydrochloride disposal must comply with local environmental regulations due to its Aquatic Acute 1 and Aquatic Chronic 1 classifications. The compound cannot be discharged to sewers or waterways and requires treatment at authorized hazardous waste facilities. Contact licensed waste management companies for proper disposal methods, which may include incineration at appropriate temperatures or specialized chemical treatment to neutralize environmental hazards.

How to transport 4-amino-2-(aminomethyl)phenol;dihydrochloride?

4-amino-2-(aminomethyl)phenol;dihydrochloride is classified as ADR Class 9 (Miscellaneous dangerous substances), Packing Group III for transportation purposes. This classification requires appropriate packaging, labeling, and documentation during shipment. Use UN-approved containers with proper hazard labels and transport documents. While less restrictive than higher-class dangerous goods, ensure compliance with ADR regulations for Class 9 substances and follow carrier-specific requirements for safe transport.

Is 4-amino-2-(aminomethyl)phenol;dihydrochloride subject to specific regulations?

4-amino-2-(aminomethyl)phenol;dihydrochloride is regulated under European CLP regulation with Warning signal word and specific hazard classifications (Acute Tox. 4, Skin Sens. 1, Aquatic toxicity). It is not currently listed as a SVHC substance under REACH regulation. Companies must comply with standard REACH registration requirements for chemical substances and ensure proper classification, labeling, and safety data sheet provision according to CLP requirements.

Where to buy 4-amino-2-(aminomethyl)phenol;dihydrochloride in Europe?

4-amino-2-(aminomethyl)phenol;dihydrochloride is available through OYSI, a established European chemical distributor specializing in high-quality chemical products. OYSI provides reliable supply chains across Europe with proper regulatory compliance and technical support. As a professional distributor, OYSI ensures appropriate packaging, documentation, and safety data sheets for industrial and research applications. Contact OYSI directly for specific quantities, specifications, and delivery requirements for your applications.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.