4-amino-2-(aminomethyl)phenol;dihydrochloride

C7H12Cl2N2O

CAS135043-64-0
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
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Identification

CAS Number
135043-64-0
EC Number
412-510-4
UN Number
3077
Index Number
612-189-00-2
PubChem CID
5463812

Physical-chemical properties

Molecular Formula
C7H12Cl2N2O
Molar Mass
211.09 g/mol
IUPAC Name
4-amino-2-(aminomethyl)phenol;dihydrochloride

Chemical Identifiers

InChI
InChI=1S/C7H10N2O.2ClH/c8-4-5-3-6(9)1-2-7(5)10;;/h1-3,10H,4,8-9H2;2*1H
InChI Key
KNHWFUNNXGJVOZ-UHFFFAOYSA-N

Overview

4-amino-2-(aminomethyl)phenol dihydrochloride (CAS 135043-64-0) is an aromatic diamine compound featuring dual amino functionalities and enhanced water solubility through salt formation. This specialized aromatic amine derivative represents a significant chemical intermediate in various industrial applications, characterized by its unique dual amino group configuration on a phenolic backbone. The dihydrochloride salt form enhances the compound's stability and water solubility compared to its free base counterpart, making it particularly valuable for aqueous-based processes and formulations. With a molecular formula of C7H12Cl2N2O and molecular weight of 211.09 g/mol, this compound exhibits distinct chemical properties that differentiate it from related aromatic amines such as 1-N-phenyl-4-N-propan-2-ylbenzene-1,4-diamine, though both share similar aromatic diamine characteristics. The safety profile requires careful handling due to its classification under multiple hazard categories including acute toxicity (Category 4), skin sensitization potential, and significant aquatic toxicity concerns for both acute and chronic exposure scenarios. The GHS07 and GHS09 pictogrammes indicate general health hazards and environmental risks, necessitating appropriate personal protective equipment and environmental containment measures during industrial handling. Primary industrial applications include its use as a chemical intermediate in pharmaceutical synthesis, where the dual amino functionality provides versatile reaction possibilities for drug development processes. Additionally, it serves as a building block in specialty polymer production and as a precursor in dye manufacturing, where the phenolic structure combined with amino groups offers excellent reactivity for chromophore development. OYSI maintains reliable supply chains for 4-amino-2-(aminomethyl)phenol dihydrochloride, ensuring consistent availability for European industrial customers requiring this specialized aromatic amine compound.

Safety & Classification

Warning
Classification:

Acute Tox. 4 *; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H302

Harmful if swallowed.

H317

May cause an allergic skin reaction.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3077
ADR Class9
Packing GroupIII
Tunnel Code-
Proper Shipping Name4-Amino-2-(aminomethyl)phenol-dihydrochlorid
Marine PollutantNo

Frequently Asked Questions

What is 4-amino-2-(aminomethyl)phenol;dihydrochloride?

4-amino-2-(aminomethyl)phenol;dihydrochloride is an organic chemical compound with the molecular formula C7H12Cl2N2O and CAS number 135043-64-0. This dihydrochloride salt has a molecular weight of 211.09 g/mol and belongs to the aminophenol family. It is classified as a hazardous substance with acute toxicity, skin sensitization properties, and aquatic toxicity concerns, requiring appropriate handling and safety measures in industrial applications.

What are the physicochemical properties of 4-amino-2-(aminomethyl)phenol;dihydrochloride?

4-amino-2-(aminomethyl)phenol;dihydrochloride is a solid compound at room temperature, typically appearing as a crystalline powder. As a dihydrochloride salt, it exhibits good water solubility due to the ionic nature of the chloride groups. The compound contains both amino and phenolic functional groups, making it reactive under certain conditions. Its molecular structure includes aromatic and aliphatic amine functionalities, contributing to its chemical reactivity and biological activity profile.

What is 4-amino-2-(aminomethyl)phenol;dihydrochloride used for?

4-amino-2-(aminomethyl)phenol;dihydrochloride is primarily used as an intermediate in pharmaceutical synthesis and fine chemical manufacturing. Its dual amino functionality makes it valuable for creating complex organic molecules through coupling reactions. The compound serves as a building block in medicinal chemistry research and drug development processes. It may also find applications in the synthesis of dyes, pigments, or specialized chemical compounds requiring aminophenol derivatives.

How to handle 4-amino-2-(aminomethyl)phenol;dihydrochloride safely?

4-amino-2-(aminomethyl)phenol;dihydrochloride requires careful handling due to its Acute Tox. 4 and Skin Sens. 1 classifications. Wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Ensure adequate ventilation in work areas and avoid skin contact and inhalation. Use in well-ventilated areas or under fume hoods. Emergency eyewash stations and safety showers should be readily accessible when handling this material.

How to store 4-amino-2-(aminomethyl)phenol;dihydrochloride correctly?

4-amino-2-(aminomethyl)phenol;dihydrochloride should be stored in a cool, dry, well-ventilated area away from direct sunlight and heat sources. Keep containers tightly closed and protect from moisture due to the hygroscopic nature of many dihydrochloride salts. Store away from incompatible materials such as strong oxidizing agents and bases. Maintain storage temperatures as recommended by the supplier and ensure proper labeling with hazard information according to GHS requirements.

What to do in case of contact with 4-amino-2-(aminomethyl)phenol;dihydrochloride?

In case of skin contact with 4-amino-2-(aminomethyl)phenol;dihydrochloride, immediately wash the affected area with plenty of water for at least 15 minutes and remove contaminated clothing. For eye contact, rinse thoroughly with water for at least 15 minutes while holding eyelids open. If inhaled, move to fresh air immediately. Given its skin sensitization properties, seek medical attention if irritation persists or allergic reactions develop. Do not induce vomiting if accidentally ingested.

How to dispose of 4-amino-2-(aminomethyl)phenol;dihydrochloride properly?

4-amino-2-(aminomethyl)phenol;dihydrochloride must be disposed of according to local and national hazardous waste regulations due to its toxicity and environmental concerns. Contact licensed waste disposal companies specializing in chemical waste management. Due to its Aquatic Acute 1 and Aquatic Chronic 1 classifications, prevent release to waterways or soil. Small quantities may require incineration at appropriate facilities, while packaging should be cleaned and disposed of according to local regulations.

How to transport 4-amino-2-(aminomethyl)phenol;dihydrochloride?

4-amino-2-(aminomethyl)phenol;dihydrochloride is classified as ADR Class 9 (Miscellaneous dangerous goods), Packing Group III for transport purposes. This classification requires appropriate packaging, labeling, and documentation during shipment. Use UN-approved packaging suitable for Class 9 materials and ensure proper hazard labels are affixed. Transport vehicles must comply with ADR requirements for Class 9 substances, and drivers should carry appropriate safety documentation and emergency response information.

Is 4-amino-2-(aminomethyl)phenol;dihydrochloride subject to specific regulations?

4-amino-2-(aminomethyl)phenol;dihydrochloride is subject to various chemical regulations including REACH registration requirements in Europe and CLP classification obligations. It carries GHS pictograms GHS07 and GHS09 with a Warning signal word, requiring appropriate safety data sheets and labeling. While not currently listed as an SVHC substance, its toxicological profile means it may be subject to workplace exposure limits and requires compliance with occupational health and safety regulations.

Where to buy 4-amino-2-(aminomethyl)phenol;dihydrochloride in Europe?

4-amino-2-(aminomethyl)phenol;dihydrochloride is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides this compound with full regulatory compliance including safety data sheets, certificates of analysis, and proper hazard classification documentation. As a professional chemical distributor, OYSI ensures quality standards and regulatory compliance for industrial and research applications throughout Europe, supporting customers with technical expertise and reliable supply chains.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.