(2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile

(2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile is an organic compound with the molecular formula C14H11NO2 and CAS number 61826-76-4. This chiral molecule features a phenoxyphenyl group attached to a hydroxyacetonitrile moiety, with a molecular weight of 225.24 g/mol. It is classified as a hazardous substance requiring careful handling due to its toxicological and environmental properties.

(2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile is a solid organic compound at room temperature with a molecular weight of 225.24 g/mol. The compound contains both polar (hydroxyl, nitrile) and non-polar (phenyl rings) functional groups, suggesting moderate solubility in polar solvents. Its aromatic structure contributes to its stability, while the presence of the nitrile and hydroxyl groups influences its reactivity and intermolecular interactions.

(2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile is primarily used as an intermediate in pharmaceutical synthesis and fine chemical manufacturing. Its chiral nature makes it valuable in asymmetric synthesis applications, particularly in the production of optically active compounds. The compound may also serve as a building block in agrochemical synthesis and specialized organic chemistry research applications requiring specific stereochemical configurations.

Safe handling of (2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile requires appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing due to its Acute Tox. 3, Eye Dam. 1, and Skin Sens. 1 classifications. Work in well-ventilated areas or under fume hoods, avoid skin and eye contact, and ensure emergency eyewash stations are accessible. Handle with care to prevent spillage and exposure.

(2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile should be stored in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep containers tightly sealed to prevent contamination and moisture absorption. Store separately from strong oxidizing agents, acids, and bases. Due to its hazardous classification, ensure storage areas comply with local chemical storage regulations and maintain appropriate spill containment measures.

Immediate first aid for (2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile exposure includes rinsing affected skin with plenty of water for at least 15 minutes and removing contaminated clothing. For eye contact, flush immediately with water for at least 15 minutes and seek medical attention due to its Eye Dam. 1 classification. If inhaled, move to fresh air. Seek immediate medical attention for all exposure incidents and provide safety data sheet to medical personnel.

Disposal of (2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile must comply with local and European waste regulations due to its hazardous classification and environmental impact (Aquatic Acute 1, Aquatic Chronic 1). Contact licensed hazardous waste disposal companies for proper treatment and disposal. Never dispose of this substance through regular drains or waste streams. Maintain disposal records and follow REACH and national chemical waste management requirements.

(2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile is classified under ADR Class 6.1 (toxic substances), Packing Group III for transportation. Shipments must use appropriate UN-specification packaging, proper labeling with GHS06, GHS05, and GHS09 pictograms, and include required transport documents. Only authorized carriers experienced in hazardous material transport should handle shipments, ensuring compliance with European ADR regulations and proper emergency response procedures.

(2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile is subject to REACH registration requirements and CLP classification regulations in Europe. While not currently listed as an SVHC, its Acute Tox. 3 and environmental hazard classifications require compliance with chemical safety assessments, proper labeling, and safety data sheet provisions. Users must follow occupational exposure limits and environmental protection measures as specified in applicable national and EU chemical legislation.

(2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile is available through OYSI, a European distributor of specialty chemical products. As an established chemical distributor, OYSI can provide this compound with proper documentation, safety data sheets, and regulatory compliance support. Contact OYSI directly for availability, specifications, and delivery options across European markets, ensuring all transactions meet REACH and transportation requirements for this hazardous substance.