2-methyl-5,6-dihydro-4H-cyclopenta[d][1,2]thiazol-3-one

2-methyl-5,6-dihydro-4H-cyclopenta[d][1,2]thiazol-3-one is a heterocyclic organic compound with the molecular formula C7H9NOS and CAS number 82633-79-2. This thiazole derivative has a molecular weight of 155.22 g/mol and features a fused cyclopentane-thiazole ring system with a ketone functional group. It is classified as a hazardous substance with significant toxicity and environmental impact properties.

2-methyl-5,6-dihydro-4H-cyclopenta[d][1,2]thiazol-3-one is a solid organic compound at room temperature with a molecular weight of 155.22 g/mol. As a heterocyclic compound containing nitrogen, oxygen, and sulfur atoms, it likely exhibits moderate polarity. The presence of the thiazole ring and ketone group suggests potential for hydrogen bonding interactions. Specific physical properties such as melting point, boiling point, and solubility data would require analytical characterization.

2-methyl-5,6-dihydro-4H-cyclopenta[d][1,2]thiazol-3-one is primarily used as an intermediate in pharmaceutical and fine chemical synthesis. Its thiazole structure makes it valuable for developing bioactive compounds, particularly in medicinal chemistry applications. The compound may also serve as a building block for agrochemical products or specialty materials. Due to its hazardous classification, its use is restricted to professional industrial applications with appropriate safety measures.

2-methyl-5,6-dihydro-4H-cyclopenta[d][1,2]thiazol-3-one requires careful handling due to its acute toxicity and eye damage potential. Essential protective equipment includes chemical-resistant gloves, safety goggles or face shield, and appropriate respiratory protection. Work should be conducted in well-ventilated areas or under fume extraction. Avoid skin and eye contact, inhalation, and ingestion. Handle containers carefully to prevent spills and ensure proper grounding when transferring to prevent static discharge.

2-methyl-5,6-dihydro-4H-cyclopenta[d][1,2]thiazol-3-one should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Due to its hazardous classification, storage must comply with local regulations for toxic substances. Keep containers upright and properly labeled with hazard information. Access should be restricted to trained personnel only. Regular inspection of storage containers is recommended to ensure integrity and prevent environmental release.

Immediate action is required for any contact with 2-methyl-5,6-dihydro-4H-cyclopenta[d][1,2]thiazol-3-one due to its toxic and corrosive properties. For skin contact, remove contaminated clothing and rinse with plenty of water for at least 15 minutes. For eye contact, flush immediately with water for at least 15 minutes and seek urgent medical attention due to potential eye damage. If inhaled, move to fresh air. If ingested, do not induce vomiting and seek immediate medical attention.

2-methyl-5,6-dihydro-4H-cyclopenta[d][1,2]thiazol-3-one must be disposed of as hazardous waste according to local and European regulations due to its toxicity and aquatic hazard classification. Disposal should only be conducted by licensed waste management companies specialized in toxic chemical waste. Container residues require the same treatment as the pure substance. Incineration at high temperatures in approved facilities is typically the preferred method. Never discharge to sewers, waterways, or regular waste streams.

2-methyl-5,6-dihydro-4H-cyclopenta[d][1,2]thiazol-3-one is classified under ADR Class 6.1 (Toxic substances), Packing Group III for transport. This requires appropriate UN-specification packaging, proper labeling with toxic hazard markings, and transport documentation. Vehicles must carry appropriate emergency equipment and drivers need ADR certification for Class 6.1 substances. Special precautions are needed to prevent container damage and environmental release during transit. Professional logistics companies experienced with hazardous chemicals should handle transportation.

2-methyl-5,6-dihydro-4H-cyclopenta[d][1,2]thiazol-3-one is subject to REACH registration requirements and CLP classification obligations in Europe. It is classified with multiple hazard categories including acute toxicity, eye damage, skin sensitization, and aquatic hazards, requiring appropriate safety data sheets and hazard communication. While not currently listed as SVHC, its hazardous properties require compliance with occupational health regulations and potential restrictions on use. Import and handling may require specific permits depending on national legislation.

2-methyl-5,6-dihydro-4H-cyclopenta[d][1,2]thiazol-3-one is available through OYSI, a specialized European distributor of technical chemicals and intermediates. As a hazardous substance requiring professional handling, it is typically supplied only to qualified industrial customers with appropriate safety infrastructure. OYSI provides comprehensive documentation including safety data sheets and certificates of analysis. Due to the substance's classification and regulatory requirements, procurement requires verification of intended use and compliance with applicable regulations.