2-sulfanylacetic acid

C2H4O2S

CAS68-11-1
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
Danger

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Identification

CAS Number
68-11-1
EC Number
200-677-4
UN Number
1940
Index Number
607-090-00-6
PubChem CID
1133

Physical-chemical properties

Molecular Formula
C2H4O2S
Molar Mass
92.12 g/mol
IUPAC Name
2-sulfanylacetic acid

Chemical Identifiers

InChI
InChI=1S/C2H4O2S/c3-2(4)1-5/h5H,1H2,(H,3,4)
InChI Key
CWERGRDVMFNCDR-UHFFFAOYSA-N

Overview

2-sulfanylacetic acid (CAS 68-11-1) is an organosulfur carboxylic acid with strong reducing properties and distinctive thiol functionality. This chemical compound, also known as thioglycolic acid, represents a critical intermediate in various industrial processes due to its unique combination of carboxyl and thiol functional groups. The molecular structure C2H4O2S enables diverse chemical reactions, making it valuable across multiple technical applications. With a molecular weight of 92.12 g/mol, this colorless to pale yellow liquid exhibits characteristic properties typical of both carboxylic acids and thiols. The safety profile of 2-sulfanylacetic acid requires careful handling protocols, as indicated by its classification as Acute Tox. 3 and Skin Corr. 1B under GHS regulations. The compound displays corrosive properties and poses acute toxicity risks through multiple exposure routes, necessitating appropriate personal protective equipment and ventilation systems during handling. Its ADR Class 8 classification reflects its corrosive nature during transport and storage. Industrial applications primarily focus on cosmetic and personal care formulations, particularly in hair treatment products where its reducing properties facilitate permanent wave solutions and hair straightening processes. Additionally, the compound serves as a key intermediate in pharmaceutical synthesis and metal processing applications, where its chelating properties prove valuable. The chemical's reactivity profile differs notably from related organosulfur compounds such as tribromoborane, which exhibits different coordination chemistry characteristics. The distinctive thiol functionality makes 2-sulfanylacetic acid essential for specialized chemical processes requiring controlled reduction reactions. OYSI maintains reliable supply chains for this technical chemical, ensuring consistent availability for European industrial customers requiring high-quality organosulfur intermediates.

Safety & Classification

Danger
Classification:

Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; Skin Corr. 1B

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H331

Toxic if inhaled.

H311

Toxic in contact with skin.

H301

Toxic if swallowed.

H314

Causes severe skin burns and eye damage.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number1940
ADR Class8
Packing GroupII
Tunnel CodeE
Proper Shipping NameThioglycolsäure
Marine PollutantNo

Frequently Asked Questions

What is 2-sulfanylacetic acid?

2-sulfanylacetic acid is an organosulfur compound with the molecular formula C2H4O2S and CAS number 68-11-1. This chemical features both a carboxylic acid group and a thiol (sulfhydryl) group in its structure, giving it unique reactivity. With a molecular weight of 92.12 g/mol, it is classified as a highly hazardous substance due to its acute toxicity and corrosive properties, requiring careful handling in industrial applications.

What are the physicochemical properties of 2-sulfanylacetic acid?

2-sulfanylacetic acid is typically found as a white to off-white crystalline solid at room temperature. The compound exhibits a characteristic strong, unpleasant sulfur-like odor due to its thiol group. It is highly soluble in water and polar solvents due to its carboxylic acid functionality. The presence of both carboxyl and thiol groups makes it reactive and prone to oxidation, particularly when exposed to air and moisture.

What is 2-sulfanylacetic acid used for?

2-sulfanylacetic acid serves as an important intermediate in pharmaceutical synthesis and biochemical research. It is commonly used in the production of various drugs and as a building block for more complex organosulfur compounds. The compound finds applications in analytical chemistry as a reagent and in the synthesis of metal chelating agents. Its dual functional groups make it valuable for creating specialized chemical compounds in research and industrial processes.

How to handle 2-sulfanylacetic acid safely?

2-sulfanylacetic acid requires strict safety protocols due to its corrosive and toxic nature. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, face shields, and protective clothing. Work must be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid direct skin contact and ensure emergency shower facilities are readily accessible. Only trained personnel should handle this substance, following established chemical safety procedures.

How to store 2-sulfanylacetic acid correctly?

2-sulfanylacetic acid must be stored in tightly sealed, corrosion-resistant containers in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep away from strong oxidizing agents, bases, and metals that could react with the compound. Storage areas should be equipped with appropriate spill containment and emergency response equipment. Regular container inspection is essential to prevent leakage and maintain product integrity.

What to do in case of contact with 2-sulfanylacetic acid?

Immediate action is critical following exposure to 2-sulfanylacetic acid. For skin contact, immediately flush the affected area with copious amounts of water for at least 15 minutes while removing contaminated clothing. If inhaled, move the person to fresh air immediately. In case of eye contact, rinse thoroughly with water for at least 15 minutes. Seek immediate medical attention for all exposures, as this substance can cause severe burns and systemic toxicity.

How to dispose of 2-sulfanylacetic acid appropriately?

2-sulfanylacetic acid disposal must comply with local, national, and international hazardous waste regulations. The substance cannot be disposed of in regular waste streams due to its corrosive and toxic properties. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Small quantities may require neutralization under controlled conditions before disposal. Always consult current waste disposal regulations and safety data sheets for specific disposal requirements in your jurisdiction.

How to transport 2-sulfanylacetic acid?

2-sulfanylacetic acid is classified under ADR Class 8 (corrosive substances), Packing Group II, indicating high hazard level for transportation. Packages must meet UN specification standards for corrosive materials and be properly labeled with appropriate hazard markings and documentation. Transportation requires compliance with dangerous goods regulations, including proper packaging, labeling, and documentation. Only certified carriers experienced in handling corrosive chemicals should transport this substance.

Is 2-sulfanylacetic acid subject to specific regulations?

2-sulfanylacetic acid is subject to comprehensive chemical regulations including REACH registration requirements in Europe and CLP classification as a dangerous substance. It is not currently listed as a Substance of Very High Concern (SVHC), but its acute toxicity and corrosive properties require strict compliance with occupational safety regulations. Users must maintain safety data sheets, implement risk assessments, and follow workplace exposure limits as mandated by chemical safety legislation.

Where to buy 2-sulfanylacetic acid in Europe?

2-sulfanylacetic acid is available through OYSI, a specialized European distributor of technical chemicals serving industrial and research customers across Europe. As an established chemical supplier, OYSI provides quality-assured products with complete regulatory documentation and technical support. Professional buyers can access this controlled substance through OYSI's network, ensuring compliance with all applicable regulations and proper handling guidance for safe use in industrial applications.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.