2-bromoacetic acid

2-bromoacetic acid is an organobromide chemical compound with the molecular formula C2H3BrO2 and CAS number 79-08-3. This halogenated carboxylic acid has a molecular weight of 138.95 g/mol and appears as a crystalline solid at room temperature. It is classified as a highly hazardous substance due to its acute toxicity, corrosive properties, and skin sensitizing effects. The compound is widely used as an intermediate in organic synthesis and pharmaceutical manufacturing.

2-bromoacetic acid is a white to pale yellow crystalline solid with a sharp, acetic acid-like odor. It is highly soluble in water and polar organic solvents such as ethanol and acetone. The compound has a melting point around 50°C and is hygroscopic, meaning it readily absorbs moisture from air. Due to the presence of the bromine atom, it exhibits enhanced reactivity compared to acetic acid and can undergo various substitution reactions.

2-bromoacetic acid serves primarily as an alkylating agent and synthetic intermediate in organic chemistry. It is extensively used in pharmaceutical manufacturing for producing various drug compounds, particularly in the synthesis of amino acids and peptides. The compound also finds applications in the production of cosmetic ingredients, agrochemicals, and specialty chemicals. Additionally, it is used in research laboratories for protein modification and as a reagent in analytical chemistry procedures.

2-bromoacetic acid requires strict safety measures due to its corrosive and toxic nature. Always wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work in a well-ventilated area or under a fume hood to avoid inhalation. Avoid direct skin and eye contact as the substance can cause severe burns and tissue damage. Use proper handling tools and ensure emergency shower and eyewash stations are readily accessible.

2-bromoacetic acid should be stored in a cool, dry, well-ventilated area away from direct sunlight and heat sources. Keep containers tightly closed and store in original packaging made of compatible materials. Separate from incompatible substances such as strong bases, reducing agents, and metals. Store below 25°C in a designated chemical storage area with appropriate secondary containment. Ensure storage areas are equipped with spill control materials and maintain proper inventory records.

Immediate action is critical due to the corrosive nature of 2-bromoacetic acid. For skin contact, immediately remove contaminated clothing and flush affected area with copious amounts of water for at least 15 minutes. For eye contact, rinse immediately with water for at least 15 minutes while holding eyelids open. If inhaled, move to fresh air immediately. If ingested, do not induce vomiting and rinse mouth with water. Seek immediate medical attention in all cases of exposure.

2-bromoacetic acid disposal must comply with local, national, and international environmental regulations. The substance cannot be disposed of in regular waste streams due to its hazardous classification. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Small quantities may be neutralized carefully under controlled conditions by trained personnel, but this should only be done following specific protocols. Always consult safety data sheets and local authorities before disposal.

2-bromoacetic acid is classified as ADR Class 8 (corrosive substances), Packing Group II, indicating moderate danger during transport. It must be packaged in UN-approved containers with proper labeling including corrosive hazard symbols. Transport vehicles must carry appropriate documentation, emergency response information, and safety equipment. Only trained and certified personnel should handle transportation. Special precautions are required to prevent spills and ensure compatibility with transport vessel materials.

2-bromoacetic acid is subject to comprehensive chemical regulations including REACH registration in Europe and CLP classification requirements. It is classified with multiple hazard classes including Acute Toxicity Category 3, Skin Corrosion 1A, and Skin Sensitization Category 1. While not currently listed as a Substance of Very High Concern (SVHC), it requires safety data sheets, proper labeling with GHS pictograms (GHS05, GHS06, GHS09), and compliance with occupational exposure limits.

2-bromoacetic acid is available through OYSI, a specialized European distributor of technical chemicals and laboratory reagents. OYSI provides high-quality 2-bromoacetic acid with complete regulatory documentation including safety data sheets, certificates of analysis, and REACH compliance information. As a professional chemical distributor, OYSI ensures proper packaging, labeling, and transportation according to ADR regulations, serving customers across Europe with reliable supply chain solutions for industrial and research applications.