2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide

C12H18ClNO2S

CAS163515-14-8
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
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Identification

CAS Number
163515-14-8
EC Number
605-329-9
UN Number
3082
Index Number
616-215-00-3
PubChem CID
13633097

Physical-chemical properties

Molecular Formula
C12H18ClNO2S
Molar Mass
275.80 g/mol
IUPAC Name
2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide

Chemical Identifiers

InChI
InChI=1S/C12H18ClNO2S/c1-8-7-17-10(3)12(8)14(11(15)5-13)9(2)6-16-4/h7,9H,5-6H2,1-4H3/t9-/m0/s1
InChI Key
JLYFCTQDENRSOL-VIFPVBQESA-N

Overview

2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide (CAS 163515-14-8) is a chlorinated thiophene derivative with selective biological activity and moderate environmental persistence. This specialized organic compound belongs to the thiophene acetamide class, characterized by its unique structural combination of a substituted thiophene ring system and a chiral methoxypropyl side chain. The presence of the chloroacetamide functional group contributes to its biological activity profile, while the 2,4-dimethylthiophene moiety provides structural specificity for targeted applications. The compound exhibits notable physical and chemical properties that influence its handling and application requirements. Its molecular structure, featuring both lipophilic thiophene components and polar functional groups, results in moderate solubility characteristics across different solvent systems. The stereochemical configuration at the (2S)-1-methoxypropan-2-yl position is critical for its biological specificity and distinguishes it from related acetamide derivatives. From a safety perspective, this substance requires careful handling protocols due to its classification as Acute Tox. 4 and Skin Sens. 1 under GHS regulations. The compound also presents environmental considerations with its Aquatic Acute 1 and Aquatic Chronic 1 classifications, necessitating appropriate containment and disposal measures. Unlike simpler compounds such as propyl 3,4,5-trihydroxybenzoate, this thiophene derivative requires specialized storage conditions and enhanced personal protective equipment during handling. Primary industrial applications include use as an intermediate in pharmaceutical synthesis, specialty agrochemical formulations, and as a research chemical for biological studies. The compound's selectivity profile makes it valuable in developing targeted therapeutic agents and crop protection products. OYSI maintains reliable supply chains for this specialized thiophene acetamide derivative, supporting European industrial and research applications with comprehensive technical documentation and regulatory compliance support.

Safety & Classification

Warning
Classification:

Acute Tox. 4; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H302

Harmful if swallowed.

H317

May cause an allergic skin reaction.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3082
ADR Class9
Packing GroupIII
Tunnel Code-
Proper Shipping NameDimethenamid-P (ISO)
Marine PollutantNo

Frequently Asked Questions

What is 2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide?

2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide is an organic compound with the molecular formula C12H18ClNO2S and CAS number 163515-14-8. This chloroacetamide derivative contains a thiophene ring system and has a molecular weight of 275.8 g/mol. It is classified as a hazardous substance with acute toxicity and skin sensitization properties, requiring careful handling in industrial applications.

What are the physicochemical properties of 2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide?

2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide is an organic compound with a molecular weight of 275.8 g/mol. The substance contains chlorine, nitrogen, oxygen, and sulfur atoms within its structure, featuring both a thiophene ring and an acetamide functional group. Its specific physical properties such as melting point, boiling point, and solubility characteristics should be confirmed through technical data sheets for precise handling requirements.

What is 2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide used for?

2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide is typically used as a chemical intermediate in pharmaceutical and agrochemical synthesis. Its acetamide structure and thiophene ring system make it valuable for developing bioactive compounds. The substance may serve as a building block in the production of more complex molecules, particularly in research and development applications within the pharmaceutical industry where precise molecular modifications are required.

How to handle 2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide safely?

2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide requires careful handling due to its Acute Tox. 4 and Skin Sens. 1 classifications. Wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Ensure adequate ventilation in work areas and avoid direct skin contact or inhalation. Handle in well-ventilated areas or under fume hoods, and wash hands thoroughly after use to prevent sensitization reactions.

How to store 2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide correctly?

2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide should be stored in a cool, dry, well-ventilated area away from incompatible materials. Keep containers tightly closed and protected from moisture and heat sources. Due to its hazardous classification, store in designated chemical storage areas with appropriate secondary containment. Ensure storage areas are equipped with spill control measures and restrict access to trained personnel only.

What to do in case of contact with 2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide?

In case of skin contact with 2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide, immediately wash the affected area with plenty of soap and water for at least 15 minutes. Remove contaminated clothing immediately. If eye contact occurs, rinse thoroughly with water for several minutes. Due to its skin sensitization properties, seek medical attention if irritation develops or persists. For inhalation, move to fresh air immediately and seek medical advice if symptoms occur.

How to dispose of 2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide appropriately?

2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide must be disposed of as hazardous waste according to local and national regulations. Due to its Aquatic Acute 1 and Aquatic Chronic 1 classifications, prevent release to the environment. Contact licensed waste disposal companies for proper treatment and disposal. Do not discharge to sewers or waterways. Contaminated packaging should also be treated as hazardous waste and disposed of through appropriate channels.

How to transport 2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide?

2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide is classified as ADR Class 9 (Miscellaneous dangerous goods), Packing Group III for transport purposes. This classification requires appropriate UN-specification packaging and proper documentation during shipment. Packages must be properly labeled with hazard labels and UN markings. Transport vehicles should comply with ADR regulations for Class 9 substances, and drivers must have appropriate training and documentation.

Is 2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide subject to specific regulations?

2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide is subject to REACH regulation in Europe and must comply with CLP classification requirements. It is not currently listed as a Substance of Very High Concern (SVHC). The substance requires appropriate safety data sheets and hazard communication due to its Warning signal word and GHS07/GHS09 pictogram classifications. Users must follow occupational exposure limits and environmental protection measures as specified in local regulations.

Where to buy 2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide in Europe?

2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide is available through OYSI, a specialized European distributor of chemical products. OYSI provides reliable supply chains for industrial chemicals and ensures proper documentation, packaging, and compliance with European regulations. As a trusted chemical distributor, OYSI offers technical support and maintains inventory of specialty chemicals for pharmaceutical and industrial applications across European markets.

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2-chloro-N-(2,4-dimethylthiophen-3-yl)-N-[(2S)-1-methoxypropan-2-yl]acetamide is a dangerous good. We support you with labeling, packaging, and transport documentation.

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Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.