2-bromopropane

C3H7Br

CAS75-26-3
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
Danger

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Identification

CAS Number
75-26-3
EC Number
200-855-1
UN Number
2344
Index Number
602-085-00-5
PubChem CID
6358

Physical-chemical properties

Molecular Formula
C3H7Br
Molar Mass
122.99 g/mol
IUPAC Name
2-bromopropane

Chemical Identifiers

InChI
InChI=1S/C3H7Br/c1-3(2)4/h3H,1-2H3
InChI Key
NAMYKGVDVNBCFQ-UHFFFAOYSA-N

Overview

2-bromopropane (CAS 75-26-3) is a halogenated hydrocarbon compound with significant industrial applications and notable safety considerations requiring careful handling protocols. This organic bromide compound, also known by its IUPAC name 2-bromopropane, represents an important member of the alkyl halide family used extensively in chemical synthesis and industrial processes. With a molecular formula of C3H7Br and molecular weight of 122.99 g/mol, this colorless liquid exhibits characteristic properties typical of secondary alkyl bromides, including moderate volatility and high reactivity in nucleophilic substitution reactions. The compound carries significant safety classifications under the CLP regulation, including Flammable Liquid Category 2, Reproductive Toxicity Category 1A, and Specific Target Organ Toxicity Category 2. These classifications necessitate stringent handling procedures and appropriate personal protective equipment during industrial use. The GHS02 and GHS08 pictograms indicate both fire hazards and serious health risks, while the ADR Class 3 classification governs its transportation requirements as a flammable liquid. In industrial applications, 2-bromopropane serves primarily as a synthetic intermediate in pharmaceutical manufacturing, as a solvent in specialized chemical processes, and in the production of various organic compounds. Its reactivity profile makes it particularly valuable in nucleophilic substitution reactions where bromide serves as an effective leaving group. While sharing some applications with compounds like ethylbenzene in solvent applications, 2-bromopropane offers distinct advantages in specific synthetic pathways due to its unique molecular structure. The compound requires specialized storage conditions and handling expertise due to its reproductive toxicity classification and flammable nature. OYSI provides 2-bromopropane to qualified industrial customers with comprehensive safety documentation and regulatory compliance support.

Safety & Classification

Danger
Classification:

Flam. Liq. 2; Repr. 1A; STOT RE 2 *

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H225

Highly flammable liquid and vapour.

H373

May cause damage to organs through prolonged or repeated exposure.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Transport (ADR)

UN Number2344
ADR Class3
Packing GroupII
Tunnel CodeD/E
Proper Shipping Name2-Brompropan
Marine PollutantNo

Frequently Asked Questions

What is 2-bromopropane?

2-bromopropane is an organobromine compound with the molecular formula C3H7Br and CAS number 75-26-3. It is a secondary alkyl halide where a bromine atom is attached to the middle carbon of a propane chain. With a molecular weight of 122.99 g/mol, this compound is classified as a flammable liquid and reproductive toxicant category 1A, making it a substance of significant regulatory concern due to its hazardous properties.

What are the physicochemical properties of 2-bromopropane?

2-bromopropane is a colorless liquid at room temperature with a characteristic sweet, chloroform-like odor. It has a boiling point of approximately 59-60°C and is relatively volatile. The compound is sparingly soluble in water but readily miscible with organic solvents such as alcohols, ethers, and hydrocarbons. Its density is higher than water at about 1.31 g/cm³, and it exhibits typical properties of secondary alkyl halides.

What is 2-bromopropane used for?

2-bromopropane is primarily used as an intermediate in organic synthesis and pharmaceutical manufacturing. It serves as an alkylating agent in various chemical reactions and is employed in the production of specialty chemicals. The compound is also utilized in research laboratories for synthetic chemistry applications. However, due to its reproductive toxicity classification (Repr. 1A), its industrial applications have become increasingly restricted and regulated in many jurisdictions.

How to handle 2-bromopropane safely?

2-bromopropane requires strict safety measures due to its flammable and reproductive toxic properties. Personnel must wear appropriate PPE including chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation. Eliminate all ignition sources as it's classified as Flam. Liq. 2. Avoid skin contact and inhalation, and implement proper hygiene measures including thorough handwashing after handling.

How to store 2-bromopropane correctly?

2-bromopropane should be stored in a cool, dry, well-ventilated area away from heat sources, sparks, and open flames due to its flammable nature. Keep containers tightly closed and store in appropriate secondary containment. The storage area must be equipped with fire suppression systems and maintained below 25°C when possible. Separate from oxidizing agents, strong bases, and incompatible materials. Ensure proper labeling with GHS02 and GHS08 pictograms and danger signal word.

What to do in case of contact with 2-bromopropane?

In case of skin contact with 2-bromopropane, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. If inhaled, move the person to fresh air immediately and seek medical attention. For eye contact, rinse with plenty of water for at least 15 minutes and remove contact lenses if present. Due to its reproductive toxicity, seek immediate medical advice in all exposure cases and inform healthcare providers of the specific substance involved.

How to dispose of 2-bromopropane appropriately?

2-bromopropane disposal must comply with local and national hazardous waste regulations due to its classification as a dangerous substance. The compound cannot be disposed of through regular waste streams and requires treatment by licensed hazardous waste disposal companies. Incineration at high temperatures in appropriate facilities is typically the preferred method. Containers must be properly labeled and documented with waste tracking forms. Never pour down drains or release into the environment.

How to transport 2-bromopropane?

2-bromopropane is classified under ADR Class 3 (flammable liquids), Packing Group II, indicating moderate danger level for transport. It requires appropriate UN specification packaging and proper labeling with Class 3 hazard labels. Transport vehicles must comply with ADR regulations including proper ventilation and fire safety equipment. Drivers require ADR certification for dangerous goods transport. Shipping documents must include proper shipping names, UN numbers, and emergency response information according to international transport regulations.

Is 2-bromopropane subject to particular regulations?

2-bromopropane is subject to strict regulations under REACH and CLP in Europe due to its Repr. 1A classification. It requires authorization for certain uses and is subject to restriction measures. The compound must be registered under REACH for commercial use above tonnage thresholds. Workplace exposure limits apply, and employers must implement risk management measures. Special labeling requirements include danger signal word and GHS08/GHS02 pictograms. Some applications may be prohibited or require specific authorization.

Where to buy 2-bromopropane in Europe?

2-bromopropane is available through specialized chemical distributors in Europe, including OYSI, which supplies high-quality chemicals to industrial and research customers across European markets. Due to its regulatory status as a reproductive toxicant, purchases typically require proper documentation, end-use declarations, and compliance with REACH obligations. Buyers must demonstrate appropriate handling capabilities and regulatory compliance. Contact OYSI for availability, technical specifications, and regulatory guidance for your specific application requirements.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.