2-bromopropane

C3H7Br

CAS75-26-3
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
Danger

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Identification

CAS Number
75-26-3
EC Number
200-855-1
UN Number
2344
Index Number
602-085-00-5
PubChem CID
6358

Physical-chemical properties

Molecular Formula
C3H7Br
Molar Mass
122.99 g/mol
IUPAC Name
2-bromopropane

Chemical Identifiers

InChI
InChI=1S/C3H7Br/c1-3(2)4/h3H,1-2H3
InChI Key
NAMYKGVDVNBCFQ-UHFFFAOYSA-N

Overview

2-bromopropane (CAS 75-26-3) is an organobromine compound with halogenated alkane properties used primarily as an intermediate in organic synthesis. This colorless liquid, with the molecular formula C3H7Br, belongs to the family of secondary alkyl halides and serves as a versatile building block in pharmaceutical and chemical manufacturing processes. As a flammable liquid classified under GHS02 and GHS08 pictograms, 2-bromopropane requires careful handling due to its significant health hazards. The compound carries a Danger signal word and is classified as Flam. Liq. 2, Repr. 1A, and STOT RE 2, indicating reproductive toxicity concerns and potential for repeated exposure organ damage. Its ADR Class 3 classification reflects its flammable nature, with proper storage and transportation protocols essential for safe handling. The compound exhibits typical secondary alkyl halide reactivity, making it valuable in nucleophilic substitution reactions and elimination processes. Its bromine functionality enables various chemical transformations, including conversion to alcohols, ethers, and other functional groups through established synthetic methodologies. Unlike simpler compounds such as ethylbenzene, 2-bromopropane's halogen substituent provides enhanced reactivity for specialized applications. Primary industrial applications include pharmaceutical intermediate synthesis, where its controlled reactivity enables the construction of complex molecular frameworks. The compound also serves in specialty chemical manufacturing and research applications requiring precise substitution patterns. Additionally, it functions as a reagent in organic synthesis laboratories for academic and industrial research purposes. OYSI maintains reliable supply chains for 2-bromopropane, ensuring consistent availability for European customers requiring this specialized organobromine intermediate for their chemical manufacturing and research operations.

Safety & Classification

Danger
Classification:

Flam. Liq. 2; Repr. 1A; STOT RE 2 *

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H225

Highly flammable liquid and vapour.

H373

May cause damage to organs through prolonged or repeated exposure.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Transport (ADR)

UN Number2344
ADR Class3
Packing GroupII
Tunnel CodeD/E
Proper Shipping Name2-Brompropan
Marine PollutantNo

Frequently Asked Questions

What is 2-bromopropane?

2-bromopropane is an organohalogen compound with the molecular formula C3H7Br and CAS number 75-26-3. This secondary alkyl bromide has a molecular weight of 122.99 g/mol and belongs to the family of brominated hydrocarbons. It is classified as a flammable liquid with significant health hazards, including reproductive toxicity and potential for causing specific target organ toxicity after repeated exposure.

What are the physicochemical properties of 2-bromopropane?

2-bromopropane is a colorless liquid at room temperature with a characteristic sweet, chloroform-like odor. It has a boiling point of approximately 59°C and a density higher than water. The compound is moderately soluble in water but readily miscible with most organic solvents including alcohols, ethers, and hydrocarbons. It exhibits typical properties of secondary alkyl halides and is relatively volatile.

What is 2-bromopropane used for?

2-bromopropane is primarily used as a chemical intermediate in organic synthesis and pharmaceutical manufacturing. It serves as an alkylating agent in various chemical reactions and is employed in the production of specialty chemicals. The compound finds applications in research laboratories for synthetic chemistry work and as a reagent in the preparation of other brominated compounds. Its use is restricted due to health concerns.

How to handle 2-bromopropane safely?

2-bromopropane requires careful handling due to its reproductive toxicity and flammability. Use appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and respiratory protection in well-ventilated areas. Avoid skin contact and inhalation of vapors. Work away from ignition sources and use grounding equipment to prevent static discharge. Handle only in designated areas with proper ventilation and emergency equipment readily available.

How to store 2-bromopropane correctly?

2-bromopropane should be stored in a cool, dry, well-ventilated area away from heat sources, sparks, and open flames. Keep containers tightly closed and store in original packaging in a designated flammable liquids storage area. Avoid storage near incompatible materials such as strong oxidizing agents, bases, and reactive metals. Maintain storage temperatures below 25°C and ensure proper labeling and inventory management.

What to do in case of contact with 2-bromopropane?

2-bromopropane exposure requires immediate action due to its toxicity. For skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water for at least 15 minutes. If inhaled, move to fresh air immediately and seek medical attention. For eye contact, flush with clean water for 15 minutes. In all cases of exposure, seek immediate medical attention and provide the safety data sheet to medical personnel.

How to dispose of 2-bromopropane appropriately?

2-bromopropane disposal must comply with local and national hazardous waste regulations. The substance cannot be disposed of in regular waste streams due to its classification as hazardous waste. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Small quantities may be suitable for incineration at approved facilities. Always consult local environmental authorities and maintain proper documentation of disposal activities.

How to transport 2-bromopropane?

2-bromopropane is classified as ADR Class 3 (flammable liquids), Packing Group II for transportation purposes. It requires proper packaging in UN-approved containers with appropriate hazard labels and documentation. Transport vehicles must comply with ADR regulations for Class 3 substances, including proper ventilation, fire extinguishers, and driver certification. Shipping papers must include proper shipping names, hazard class, and emergency response information.

Is 2-bromopropane subject to specific regulations?

2-bromopropane is subject to stringent regulations under REACH and CLP in Europe due to its reproductive toxicity classification (Repr. 1A). It requires registration, safety data sheets, and proper classification and labeling. The substance may face restrictions or authorization requirements due to its hazardous properties. Users must comply with occupational exposure limits and implement appropriate risk management measures as specified in regulatory guidance.

Where to buy 2-bromopropane in Europe?

2-bromopropane is available through specialized chemical distributors in Europe, including OYSI, which supplies high-quality chemical products to industrial and research customers. Due to its hazardous classification and regulatory requirements, purchases typically require proper documentation and compliance verification. Contact OYSI's technical team for availability, specifications, and regulatory support to ensure proper handling and compliance with applicable regulations throughout Europe.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.