2-chloro-5-(chloromethyl)-1,3-thiazole

2-chloro-5-(chloromethyl)-1,3-thiazole is an organosulfur heterocyclic compound with the molecular formula C4H3Cl2NS and CAS number 105827-91-6. This thiazole derivative contains two chlorine substituents and has a molecular weight of 168.04 g/mol. It is classified as a hazardous substance with corrosive and toxic properties, requiring careful handling in industrial applications. The compound belongs to the thiazole family, which are important building blocks in pharmaceutical and agrochemical synthesis.

2-chloro-5-(chloromethyl)-1,3-thiazole is a chlorinated thiazole compound with a molecular weight of 168.04 g/mol and molecular formula C4H3Cl2NS. As a substituted thiazole, it typically appears as a crystalline solid at room temperature. The presence of two chlorine atoms and the thiazole ring system influences its chemical reactivity and solubility properties. Specific physical properties such as melting point, boiling point, and solubility data should be consulted from detailed technical datasheets for precise handling requirements.

2-chloro-5-(chloromethyl)-1,3-thiazole is primarily used as an intermediate in organic synthesis, particularly in pharmaceutical and agrochemical manufacturing. The compound serves as a building block for the synthesis of more complex thiazole derivatives and heterocyclic compounds. Its reactive chloromethyl group makes it valuable for further chemical transformations. Industrial applications include the production of active pharmaceutical ingredients, pesticides, and specialty chemicals where thiazole moieties are required for biological activity.

2-chloro-5-(chloromethyl)-1,3-thiazole must be handled with extreme caution due to its corrosive and toxic properties. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, face protection, and protective clothing. Work should be conducted in a well-ventilated area or under fume hood to avoid inhalation. The compound is classified as Skin Corr. 1B and Acute Tox. 3/4, requiring immediate medical attention in case of skin contact. Always follow established safety protocols and have emergency procedures readily available.

2-chloro-5-(chloromethyl)-1,3-thiazole should be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from incompatible materials. As a corrosive substance (ADR Class 8), it requires segregation from bases, metals, and oxidizing agents. Storage areas must be equipped with appropriate spill containment and emergency equipment. The container should be clearly labeled with hazard information and kept away from heat sources, direct sunlight, and moisture to prevent degradation or hazardous reactions.

Immediate action is required in case of contact with 2-chloro-5-(chloromethyl)-1,3-thiazole due to its corrosive nature. For skin contact, immediately remove contaminated clothing and flush the affected area with copious amounts of water for at least 15 minutes. In case of eye contact, rinse thoroughly with water and seek immediate medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek emergency medical care. Always consult the safety data sheet for detailed first aid measures.

2-chloro-5-(chloromethyl)-1,3-thiazole must be disposed of as hazardous waste in accordance with local, national, and European regulations. The compound cannot be disposed of in regular waste streams due to its toxic and corrosive properties. Contact licensed hazardous waste disposal companies for proper collection and treatment. Incineration at high temperatures in approved facilities is typically required. Empty containers should also be treated as hazardous waste. Always consult local environmental authorities for specific disposal requirements and documentation.

2-chloro-5-(chloromethyl)-1,3-thiazole is classified as ADR Class 8 (Corrosive substances) Packing Group II for transport purposes. This classification requires specific packaging, labeling, and documentation according to dangerous goods regulations. Vehicles must display appropriate hazard placards and drivers need ADR certification. The substance requires corrosion-resistant packaging and must be segregated from incompatible materials during transport. Shipping documents must include proper shipping names, hazard classes, and emergency response information as mandated by international transport regulations.

2-chloro-5-(chloromethyl)-1,3-thiazole is subject to various European chemical regulations including REACH and CLP. Under CLP, it is classified with multiple hazard classes requiring specific labeling and safety data sheets. The compound is not currently listed as a Substance of Very High Concern (SVHC) under REACH. However, its toxic and corrosive properties mean it falls under strict handling, storage, and transport regulations. Industrial users must comply with occupational health and safety directives, environmental protection laws, and chemical safety assessments.

2-chloro-5-(chloromethyl)-1,3-thiazole is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides this compound to industrial customers with full regulatory compliance including safety data sheets, certificates of analysis, and proper hazard classification documentation. As a professional chemical distributor, OYSI ensures proper packaging, labeling, and transport arrangements according to ADR regulations. Contact OYSI directly for availability, technical specifications, and quote requests for this specialized thiazole intermediate.