2-chloro-5-(chloromethyl)-1,3-thiazole

2-chloro-5-(chloromethyl)-1,3-thiazole is an organosulfur compound with the molecular formula C4H3Cl2NS and CAS number 105827-91-6. This thiazole derivative contains two chlorine atoms and has a molecular weight of 168.04 g/mol. It is classified as a hazardous chemical with multiple danger classifications including acute toxicity, skin corrosion, skin sensitization, and aquatic toxicity. The compound is primarily used as an intermediate in organic synthesis and pharmaceutical manufacturing.

2-chloro-5-(chloromethyl)-1,3-thiazole is an organic compound with a molecular formula C4H3Cl2NS and molecular weight of 168.04 g/mol. The compound contains a thiazole ring substituted with chlorine atoms, which influences its chemical reactivity and stability. Due to the presence of electronegative chlorine atoms and the heterocyclic thiazole structure, it exhibits specific solubility characteristics and reactivity patterns typical of halogenated heterocycles.

2-chloro-5-(chloromethyl)-1,3-thiazole is primarily used as a chemical intermediate in organic synthesis and pharmaceutical manufacturing. The compound serves as a building block for the synthesis of more complex molecules, particularly in the development of pharmaceutical compounds and agrochemicals. Its reactive chloromethyl group makes it valuable for nucleophilic substitution reactions and cross-coupling processes in medicinal chemistry and fine chemical production.

2-chloro-5-(chloromethyl)-1,3-thiazole must be handled with extreme caution due to its corrosive and toxic properties. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, face protection, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation. Avoid skin and eye contact completely, as the substance is classified as Skin Corr. 1B and can cause severe chemical burns and skin sensitization.

2-chloro-5-(chloromethyl)-1,3-thiazole should be stored in tightly sealed, corrosion-resistant containers in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Due to its corrosive nature and ADR Class 8 classification, storage areas must be equipped with appropriate containment measures and emergency equipment. Keep away from acids, bases, and oxidizing agents. Storage facilities should comply with local regulations for corrosive substances and include proper labeling with GHS pictograms.

Immediate action is required upon contact with 2-chloro-5-(chloromethyl)-1,3-thiazole due to its corrosive properties. For skin contact, remove contaminated clothing immediately and rinse affected area with copious amounts of water for at least 15 minutes. In case of eye contact, flush thoroughly with water and seek immediate medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek emergency medical care. Always consult a physician in all exposure cases.

2-chloro-5-(chloromethyl)-1,3-thiazole must be disposed of as hazardous waste in accordance with local and national environmental regulations. The compound cannot be disposed of in regular waste streams due to its toxic and corrosive properties, plus its aquatic chronic toxicity classification. Disposal should be carried out by licensed hazardous waste disposal companies through appropriate methods such as high-temperature incineration. Always consult local environmental authorities for specific disposal requirements and approved disposal facilities.

2-chloro-5-(chloromethyl)-1,3-thiazole is classified under ADR Class 8 (corrosive substances) Packing Group II, requiring specific transport regulations. Transportation must comply with dangerous goods regulations including proper packaging, labeling with appropriate hazard labels, and documentation. Vehicles must be equipped with appropriate emergency equipment and drivers must hold valid dangerous goods transport certification. Packages must display the correct UN number, proper shipping name, and hazard labels according to ADR requirements.

2-chloro-5-(chloromethyl)-1,3-thiazole is subject to multiple regulatory frameworks including REACH registration requirements in Europe and CLP classification as a hazardous substance. The compound requires proper classification, labeling, and packaging according to GHS standards with Danger signal word and specific pictograms (GHS06, GHS05, GHS09). While not currently listed as a Substance of Very High Concern (SVHC), its use is regulated under occupational health and safety legislation requiring risk assessments and protective measures.

2-chloro-5-(chloromethyl)-1,3-thiazole is available through OYSI, a specialized European distributor of fine chemicals and pharmaceutical intermediates. OYSI provides this compound with full regulatory compliance including proper documentation, safety data sheets, and certificates of analysis. As a professional chemical distributor, OYSI ensures proper handling, packaging, and delivery according to ADR transport regulations. Contact OYSI directly for availability, specifications, and pricing information for your specific requirements.