2-bromo-4,6-difluoroaniline

2-bromo-4,6-difluoroaniline is an aromatic amine compound with the molecular formula C6H4BrF2N and CAS number 444-14-4. This halogenated aniline derivative contains both bromine and fluorine substituents on the benzene ring, giving it a molecular weight of 208 g/mol. It is classified as an acute toxicity hazard (Category 4) and poses chronic aquatic toxicity risks, requiring careful handling in industrial applications.

2-bromo-4,6-difluoroaniline is typically a solid crystalline compound at room temperature due to its molecular structure and intermolecular forces. Like most halogenated anilines, it likely exhibits limited water solubility but good solubility in organic solvents. The presence of multiple halogens (bromine and fluorine) significantly influences its physical properties, including melting point, boiling point, and chemical reactivity compared to unsubstituted aniline.

2-bromo-4,6-difluoroaniline is primarily used as an intermediate in pharmaceutical synthesis and fine chemical manufacturing. Its unique substitution pattern makes it valuable for developing active pharmaceutical ingredients, agrochemicals, and specialty chemicals. The compound serves as a building block in organic synthesis, particularly in reactions requiring specific electronic and steric properties provided by the bromine and fluorine substituents on the aniline structure.

2-bromo-4,6-difluoroaniline requires careful handling due to its Acute Tox. 4 classification and Warning signal word. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume extraction systems. Avoid skin contact, inhalation, and ingestion. Handle containers carefully to prevent spills, and ensure emergency wash facilities are readily accessible during use.

2-bromo-4,6-difluoroaniline should be stored in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep containers tightly sealed to prevent contamination and moisture absorption. Store away from strong oxidizers, acids, and bases that could react with the aniline functional group. Ensure storage areas comply with local chemical storage regulations and maintain appropriate temperature controls to preserve product stability and prevent degradation.

Immediate action is required upon contact with 2-bromo-4,6-difluoroaniline due to its acute toxicity. For skin contact, remove contaminated clothing and wash thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15 minutes while holding eyelids open. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention, providing the safety data sheet to medical personnel.

2-bromo-4,6-difluoroaniline must be disposed of through licensed hazardous waste management facilities due to its toxicity and environmental impact classification (Aquatic Chronic 2). Never dispose of this substance in regular waste streams, sewers, or soil. Collect waste in appropriate containers, properly labeled with contents and hazard information. Consult local environmental regulations and work with certified waste disposal companies to ensure compliance with applicable laws and environmental protection standards.

2-bromo-4,6-difluoroaniline is classified as ADR Class 9 (Miscellaneous Dangerous Substances), Packing Group III for transportation purposes. This classification requires appropriate packaging, labeling, and documentation for road transport. Packages must bear proper shipping names, UN numbers, and hazard labels. Transport should be conducted by trained personnel familiar with dangerous goods regulations, using vehicles equipped for hazardous material transport and following established routing and emergency response procedures.

2-bromo-4,6-difluoroaniline is subject to various European chemical regulations including REACH registration requirements and CLP classification obligations. The substance is not currently listed as a Substance of Very High Concern (SVHC), but its acute toxicity and aquatic chronic toxicity classifications impose specific labeling, safety data sheet, and handling requirements. Users must comply with occupational exposure limits, environmental discharge restrictions, and proper classification according to GHS pictograms GHS07 and GHS09.

2-bromo-4,6-difluoroaniline is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides this compound with full regulatory compliance, including proper packaging, labeling, and safety documentation required for European markets. As a professional chemical supplier, OYSI ensures product quality and regulatory adherence while offering technical support for safe handling and application guidance to industrial and research customers across Europe.