2-chloro-6-(trichloromethyl)pyridine
C6H3Cl4N
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Identification
- CAS Number
- 1929-82-4
- EC Number
- 217-682-2
- UN Number
- 3077
- Index Number
- 006-057-00-8
- PubChem CID
- 16004
Physical-chemical properties
- Molecular Formula
- C6H3Cl4N
- Molar Mass
- 230.90 g/mol
- IUPAC Name
- 2-chloro-6-(trichloromethyl)pyridine
Chemical Identifiers
- InChI
- InChI=1S/C6H3Cl4N/c7-5-3-1-2-4(11-5)6(8,9)10/h1-3H
- InChI Key
- DCUJJWWUNKIJPH-UHFFFAOYSA-N
Overview
2-chloro-6-(trichloromethyl)pyridine (CAS 1929-82-4) is a chlorinated pyridine derivative with distinctive chemical reactivity and specialized industrial applications. This organochlorine compound represents an important intermediate in synthetic organic chemistry, featuring a pyridine ring substituted with both chlorine and trichloromethyl functional groups. The molecular structure C6H3Cl4N contains four chlorine atoms strategically positioned to provide unique reactivity patterns, making it valuable for various chemical transformations. With a molecular weight of 230.9 g/mol, this compound exhibits properties typical of highly chlorinated aromatic heterocycles. From a safety perspective, 2-chloro-6-(trichloromethyl)pyridine is classified under GHS as Acute Toxicity Category 4 and Aquatic Chronic Category 2, requiring appropriate handling precautions. The compound carries a Warning signal word and is associated with GHS07 and GHS09 pictograms, indicating potential health hazards and environmental concerns. Transportation falls under ADR Class 9, designating it as a miscellaneous dangerous substance requiring proper logistics protocols. The compound finds primary applications in pharmaceutical intermediate synthesis, agrochemical manufacturing, and specialty chemical production. Its chlorinated structure makes it particularly useful in nucleophilic substitution reactions and cross-coupling chemistry. Unlike simpler compounds such as diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate, this pyridine derivative offers enhanced reactivity due to its multiple chlorine substituents and heteroaromatic framework. Industrial applications typically involve its use as a building block for more complex molecules, particularly in the development of crop protection agents and pharmaceutical active ingredients. The trichloromethyl group serves as a versatile synthetic handle for further chemical modifications. OYSI provides reliable access to 2-chloro-6-(trichloromethyl)pyridine for qualified industrial customers throughout Europe, ensuring consistent quality and regulatory compliance.
Safety & Classification
Acute Tox. 4 *; Aquatic Chronic 2
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 3077 |
| ADR Class | 9 |
| Packing Group | III |
| Tunnel Code | - |
| Proper Shipping Name | Nitrapyrin (ISO) |
| Marine Pollutant | No |
Frequently Asked Questions
What is 2-chloro-6-(trichloromethyl)pyridine?
2-chloro-6-(trichloromethyl)pyridine is a chlorinated organic compound belonging to the pyridine family with the molecular formula C6H3Cl4N and CAS number 1929-82-4. This substance features a pyridine ring substituted with a chlorine atom at position 2 and a trichloromethyl group at position 6, giving it a molecular weight of 230.9 g/mol. It is classified as a hazardous chemical with acute toxicity and aquatic toxicity properties, requiring appropriate safety measures during handling and use.
What are the physicochemical properties of 2-chloro-6-(trichloromethyl)pyridine?
2-chloro-6-(trichloromethyl)pyridine is a solid chlorinated compound with characteristic properties typical of halogenated pyridines. The molecule contains four chlorine atoms and one nitrogen atom in its structure, contributing to its chemical stability and reactivity patterns. Due to its highly chlorinated nature, it likely exhibits low water solubility and higher density compared to non-halogenated pyridines. The compound's specific physical properties such as melting point, boiling point, and appearance should be confirmed through technical data sheets from suppliers.
What is 2-chloro-6-(trichloromethyl)pyridine used for?
2-chloro-6-(trichloromethyl)pyridine serves as an important intermediate in pharmaceutical and agrochemical synthesis due to its reactive chlorinated structure. The compound is commonly used in the production of active pharmaceutical ingredients, pesticides, and other specialty chemicals where selective chlorination patterns are required. Its multiple chlorine substituents make it valuable for further chemical transformations through nucleophilic substitution reactions. The compound finds applications in research and development for creating novel chemical entities in medicinal chemistry and crop protection industries.
How to handle 2-chloro-6-(trichloromethyl)pyridine safely?
2-chloro-6-(trichloromethyl)pyridine requires careful handling due to its Acute Tox. 4 classification and Warning signal word. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing to prevent skin and eye contact. Work should be conducted in well-ventilated areas or under fume hoods to avoid inhalation exposure. Handlers must be trained in proper chemical handling procedures and emergency response protocols. Regular safety training and adherence to workplace safety guidelines are mandatory when working with this hazardous substance.
How to store 2-chloro-6-(trichloromethyl)pyridine correctly?
2-chloro-6-(trichloromethyl)pyridine should be stored in a cool, dry, well-ventilated area away from heat sources and incompatible materials. The storage area must be designed to contain spills and prevent environmental release, considering its Aquatic Chronic 2 classification. Containers should be tightly sealed and properly labeled with appropriate hazard warnings including GHS07 and GHS09 pictograms. Storage facilities should comply with local chemical storage regulations and include appropriate fire suppression systems. Regular inspection of containers for integrity and proper segregation from incompatible chemicals is essential.
What to do in case of contact with 2-chloro-6-(trichloromethyl)pyridine?
Immediate action is required in case of contact with 2-chloro-6-(trichloromethyl)pyridine due to its acute toxicity properties. For skin contact, remove contaminated clothing and rinse the affected area thoroughly with water for at least 15 minutes. In case of eye contact, flush immediately with clean water and seek medical attention. If inhaled, move the person to fresh air and provide respiratory support if needed. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult the safety data sheet for specific first aid measures and contact emergency services when necessary.
How to dispose of 2-chloro-6-(trichloromethyl)pyridine properly?
2-chloro-6-(trichloromethyl)pyridine must be disposed of as hazardous waste through licensed waste management companies due to its toxic and environmentally hazardous properties. The waste should never be discharged to sewers, waterways, or regular waste streams given its Aquatic Chronic 2 classification. Proper documentation and waste tracking forms are required for disposal. Small quantities may require special treatment methods such as high-temperature incineration or chemical neutralization. Always consult local environmental regulations and work with certified hazardous waste disposal contractors for compliant disposal.
How to transport 2-chloro-6-(trichloromethyl)pyridine?
2-chloro-6-(trichloromethyl)pyridine is classified as ADR Class 9 (Miscellaneous dangerous goods), Packing Group III for transportation purposes. This classification requires specific packaging, labeling, and documentation for road transport within Europe. Vehicles must carry appropriate placarding and drivers need ADR certification for dangerous goods transport. Proper shipping papers, emergency response information, and spill cleanup materials must accompany shipments. The packaging must meet UN specification requirements and display the correct hazard labels including the Class 9 marking for miscellaneous dangerous goods.
Is 2-chloro-6-(trichloromethyl)pyridine subject to specific regulations?
2-chloro-6-(trichloromethyl)pyridine is subject to multiple regulatory frameworks including REACH registration requirements in Europe and CLP classification and labeling regulations. The compound is not currently identified as a Substance of Very High Concern (SVHC) under REACH. It must be classified and labeled according to GHS standards with Warning signal word and appropriate pictograms (GHS07, GHS09). Companies handling this substance must comply with occupational safety regulations, environmental protection requirements, and proper notification procedures. Regular regulatory updates should be monitored as chemical regulations frequently evolve.
Where to buy 2-chloro-6-(trichloromethyl)pyridine in Europe?
2-chloro-6-(trichloromethyl)pyridine is available through OYSI, a specialized European distributor of technical chemicals and intermediates. OYSI provides this compound to pharmaceutical, agrochemical, and specialty chemical industries across Europe with proper documentation and regulatory compliance. As an established chemical distributor, OYSI ensures product quality, appropriate packaging, and adherence to transport regulations for hazardous materials. Contact OYSI directly for availability, specifications, and pricing information for your specific application requirements and volume needs.
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Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.