1H-1,2,4-triazol-5-amine

1H-1,2,4-triazol-5-amine is a heterocyclic organic compound with the molecular formula C2H4N4 and CAS number 61-82-5. This triazole derivative features a five-membered ring containing three nitrogen atoms and an amino group. With a molecular weight of 84.08 g/mol, it serves as an important building block in pharmaceutical and agrochemical synthesis due to its nitrogen-rich structure and reactive amino functionality.

1H-1,2,4-triazol-5-amine is typically a white to off-white crystalline solid at room temperature. The compound exhibits good water solubility due to its polar nitrogen atoms and amino group, making it readily soluble in polar solvents. It has a relatively low molecular weight of 84.08 g/mol and contains multiple nitrogen atoms, contributing to its basic character and potential for hydrogen bonding interactions.

1H-1,2,4-triazol-5-amine serves as a key intermediate in pharmaceutical synthesis, particularly for developing antifungal agents, anticonvulsants, and other therapeutic compounds. It is also utilized in agrochemical production for manufacturing pesticides and herbicides. Additionally, this compound finds applications in materials science as a building block for polymers, coordination complexes, and specialty chemicals requiring nitrogen-rich heterocyclic structures.

1H-1,2,4-triazol-5-amine requires careful handling due to its reproductive toxicity (Repr. 2) and potential for organ damage (STOT RE 2). Always wear appropriate personal protective equipment including safety goggles, chemical-resistant gloves, and protective clothing. Work in well-ventilated areas or under fume hoods to minimize inhalation exposure. Avoid skin contact and ingestion, and wash hands thoroughly after handling.

1H-1,2,4-triazol-5-amine should be stored in a cool, dry, well-ventilated area away from direct sunlight and heat sources. Keep containers tightly sealed to prevent moisture absorption and contamination. Store separately from incompatible materials such as strong oxidizing agents. Maintain storage temperatures below 25°C and ensure proper labeling with hazard warnings. Regular inventory checks should be conducted to monitor container integrity.

In case of skin contact with 1H-1,2,4-triazol-5-amine, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. If eye contact occurs, flush immediately with clean water for 15-20 minutes. In case of inhalation, move to fresh air immediately. If ingested, do not induce vomiting and seek immediate medical attention, providing the safety data sheet to medical personnel.

1H-1,2,4-triazol-5-amine must be disposed of according to local, national, and international waste regulations due to its hazard classification. The compound should be treated as hazardous waste and collected by licensed waste disposal companies. Do not discharge into sewers, waterways, or soil due to its aquatic toxicity (Aquatic Chronic 2). Incineration at authorized facilities under controlled conditions is typically the preferred disposal method.

1H-1,2,4-triazol-5-amine is classified as ADR Class 9 (Miscellaneous dangerous substances), Packing Group III for transportation purposes. This classification requires appropriate packaging, labeling, and documentation during transport. Use UN-specification packaging and ensure proper hazard labeling including GHS08 and GHS09 pictograms. Transport vehicles must comply with ADR regulations, and drivers should carry appropriate emergency response information and safety data sheets.

1H-1,2,4-triazol-5-amine is subject to European REACH regulation requiring registration for manufacture or import above specified tonnages. The compound falls under CLP regulation with mandatory classification as Repr. 2, STOT RE 2, and Aquatic Chronic 2, requiring appropriate hazard labeling with Warning signal word. While not currently listed as SVHC, its reproductive toxicity classification means it requires careful regulatory compliance and risk assessment.

1H-1,2,4-triazol-5-amine is available through OYSI, a specialized European distributor of technical chemicals serving industrial and research customers across Europe. OYSI provides comprehensive regulatory documentation, safety data sheets, and technical support to ensure compliant procurement and use. As a professional chemical supplier, OYSI maintains appropriate certifications and expertise to handle classified substances safely and efficiently throughout the European market.