1-methylpyrrolidin-2-one

1-methylpyrrolidin-2-one is an organic chemical compound with the molecular formula C5H9NO and CAS number 872-50-4. This substance belongs to the pyrrolidinone family and has a molecular weight of 99.13 g/mol. It is classified as a hazardous substance with reproductive toxicity (Repr. 1B), specific target organ toxicity (STOT SE 3), and causes skin and eye irritation. The substance requires careful handling due to its danger classification and associated GHS pictograms GHS08 and GHS07.

1-methylpyrrolidin-2-one is a colorless to pale yellow liquid at room temperature with a characteristic mild odor. The compound has excellent solubility in water and most organic solvents, making it highly versatile for various applications. It exhibits hygroscopic properties, meaning it readily absorbs moisture from air. The substance has a relatively low molecular weight of 99.13 g/mol and contains both nitrogen and oxygen functional groups, contributing to its polar nature and solvent properties.

1-methylpyrrolidin-2-one serves as a high-performance polar aprotic solvent in pharmaceutical manufacturing, electronics cleaning, and chemical synthesis processes. It is widely used in paint strippers, polymer processing, and as a reaction medium for various chemical transformations. The substance also finds applications in membrane technology, lithium battery electrolytes, and as a penetration enhancer in topical pharmaceutical formulations. Its excellent solvency properties make it valuable for dissolving polymers, resins, and other organic compounds in industrial processes.

1-methylpyrrolidin-2-one requires careful handling with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume extraction systems to minimize inhalation exposure. Due to its reproductive toxicity classification (Repr. 1B) and skin irritation properties, direct contact must be avoided. Emergency eyewash stations and safety showers should be readily accessible. Workers should be trained on the substance's hazards and proper handling procedures before use.

1-methylpyrrolidin-2-one should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and direct sunlight. The storage area must be designed to contain spills and prevent environmental release. Due to its hygroscopic nature, containers should be kept properly sealed to prevent moisture absorption. Storage should comply with local regulations for hazardous substances and include appropriate warning labels. Keep away from incompatible materials and ensure storage areas are accessible only to trained personnel.

Immediate action is required in case of contact with 1-methylpyrrolidin-2-one due to its irritant and toxic properties. For skin contact, remove contaminated clothing and wash thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for at least 15 minutes and seek medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult safety data sheets for complete first aid procedures.

1-methylpyrrolidin-2-one must be disposed of as hazardous waste through licensed waste management companies in accordance with local environmental regulations. The substance cannot be disposed of in regular waste streams or poured down drains due to its classification and environmental impact potential. Waste containers should be properly labeled and stored securely until collection. Recovery or recycling may be possible through specialized facilities. Consult local authorities and waste management providers for specific disposal requirements and approved treatment methods.

1-methylpyrrolidin-2-one transportation must comply with international dangerous goods regulations including ADR for road transport in Europe. The substance requires appropriate packaging, labeling, and documentation according to hazardous material transport standards. Vehicles must be equipped with proper safety equipment and drivers need hazardous materials certification. Shipments should include safety data sheets and emergency response information. Transport containers must be designed to prevent leakage and properly marked with hazard identification numbers and warning labels.

1-methylpyrrolidin-2-one is subject to various European regulations including REACH registration requirements and CLP classification standards. The substance is not currently listed as an SVHC (Substance of Very High Concern) but must comply with reproductive toxicity restrictions due to its Repr. 1B classification. Industrial users must implement appropriate risk management measures and may require authorization for certain uses. Importers and manufacturers must maintain REACH compliance including safety data sheet provision and exposure scenario development for downstream users.

1-methylpyrrolidin-2-one is available through OYSI, a specialized European distributor of technical chemicals serving industrial customers across the region. OYSI provides quality-assured products with full regulatory compliance including REACH documentation and safety data sheets. The company offers technical support and regulatory guidance to ensure proper handling and application. As a professional chemical distributor, OYSI maintains inventory levels to meet industrial demand while ensuring all shipments comply with European transport and safety regulations for hazardous materials.