1-chloropropane
C3H7Cl
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Identification
- CAS Number
- 540-54-5
- EC Number
- 208-749-7
- UN Number
- 1278
- Index Number
- 602-018-00-X
- PubChem CID
- 10899
Physical-chemical properties
- Molecular Formula
- C3H7Cl
- Molar Mass
- 78.54 g/mol
- IUPAC Name
- 1-chloropropane
Chemical Identifiers
- InChI
- InChI=1S/C3H7Cl/c1-2-3-4/h2-3H2,1H3
- InChI Key
- SNMVRZFUUCLYTO-UHFFFAOYSA-N
Overview
1-Chloropropane (CAS 540-54-5) is a primary alkyl halide with flammable properties and moderate toxicity profile. This colorless liquid belongs to the chloroalkane family of organic compounds and serves as an important intermediate in chemical synthesis and industrial applications. As a three-carbon chain halogenated hydrocarbon with the molecular formula C3H7Cl, 1-chloropropane exhibits typical properties of primary alkyl chlorides. The compound features a chlorine atom attached to the terminal carbon of a propane chain, making it highly reactive in nucleophilic substitution reactions. Its relatively low molecular weight of 78.54 g/mol contributes to its volatile nature and flammable characteristics, requiring careful handling protocols. The compound presents significant safety considerations due to its classification as Flammable Liquid Category 2 and Acute Toxicity Category 4 across multiple exposure routes. The GHS02 and GHS07 pictograms indicate both fire hazards and health concerns, while its ADR Class 3 designation reflects transportation requirements for flammable liquids. Proper ventilation, fire prevention measures, and personal protective equipment are essential when working with this substance. Industrial applications of 1-chloropropane include its use as a chemical intermediate in pharmaceutical synthesis, as a solvent in specialized applications, and as a starting material for producing other organochlorine compounds. Unlike related compounds such as pyridine or ethylbenzene which serve different industrial purposes, 1-chloropropane's primary utility lies in its reactivity as an alkylating agent in organic synthesis processes. OYSI maintains reliable supply chains for 1-chloropropane and related chemical intermediates, supporting European industrial customers with consistent availability and technical expertise.
Safety & Classification
Flam. Liq. 2; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Inhalation
Measures if vapours or dust are inhaled
First Aid Actions
- +P304IF INHALED:
- +P340Remove person to fresh air and keep comfortable for breathing.
- +P311Call a POISON CENTER/doctor.
Related hazard statements:
Skin Contact
Measures if substance contacts the skin
First Aid Actions
- +P302IF ON SKIN:
- +P352Wash with plenty of water.
- +P361Take off immediately all contaminated clothing.
- +P313Get medical advice/attention.
Related hazard statements:
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 1278 |
| ADR Class | 3 |
| Packing Group | II |
| Tunnel Code | D/E |
| Proper Shipping Name | 1-Chlorpropan, rein |
| Marine Pollutant | No |
Frequently Asked Questions
What is 1-chloropropane?
1-chloropropane is a halogenated hydrocarbon with the molecular formula C3H7Cl and CAS number 540-54-5. This organic compound belongs to the alkyl halide family and has a molecular weight of 78.54 g/mol. It is classified as a flammable liquid and toxic substance, requiring careful handling due to its hazardous properties. The substance is used primarily as an industrial chemical intermediate and solvent in various chemical processes.
What are the physicochemical properties of 1-chloropropane?
1-chloropropane is a colorless liquid at room temperature with a characteristic sweet, chloroform-like odor. It has a boiling point of approximately 46-47°C and is slightly soluble in water but miscible with most organic solvents including alcohols and ethers. The compound has a density lower than water and exhibits high volatility due to its low boiling point, making vapor control essential during handling.
What is 1-chloropropane used for?
1-chloropropane serves primarily as a chemical intermediate in organic synthesis for producing other chemicals and pharmaceuticals. It is used as a solvent in various industrial processes and as a reagent in chemical reactions. The compound finds applications in the manufacture of specialty chemicals, cleaning formulations, and as a building block for more complex organic molecules in pharmaceutical and agrochemical industries.
How to handle 1-chloropropane safely?
Safe handling of 1-chloropropane requires appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to prevent vapor inhalation. Avoid contact with skin, eyes, and clothing. Keep away from heat sources, sparks, and open flames due to its flammable nature. Use explosion-proof electrical equipment in areas where vapors may be present.
How to store 1-chloropropane correctly?
1-chloropropane must be stored in a cool, dry, well-ventilated area away from heat sources, ignition sources, and direct sunlight. Use tightly sealed containers made of compatible materials and store below 25°C when possible. Keep away from oxidizing agents, strong bases, and metals that may react with the compound. Ensure proper grounding and bonding during transfer operations to prevent static electricity buildup.
What to do in case of contact with 1-chloropropane?
In case of skin contact with 1-chloropropane, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for 15 minutes and seek medical attention. If inhaled, move the person to fresh air and seek medical help if breathing difficulties occur. In case of ingestion, do not induce vomiting and seek immediate medical attention.
How to dispose of 1-chloropropane properly?
1-chloropropane waste must be disposed of according to local and national hazardous waste regulations. The substance should never be poured down drains or disposed of in regular waste. Contact licensed waste disposal companies for proper treatment, which may include incineration at appropriate high-temperature facilities or chemical treatment. Containers should be thoroughly cleaned before disposal and handled as hazardous waste if contaminated.
How to transport 1-chloropropane?
1-chloropropane is classified under ADR as Class 3 (flammable liquid), Packing Group II, indicating moderate danger during transport. It must be packaged in UN-approved containers with proper labeling including flammable liquid hazard labels. Transport vehicles must comply with ADR requirements for flammable liquids, including proper ventilation, fire extinguishing equipment, and trained drivers with appropriate certification for dangerous goods transport.
Is 1-chloropropane subject to specific regulations?
1-chloropropane is regulated under European CLP regulation with classification as Flam. Liq. 2 and Acute Tox. 4, requiring appropriate hazard labeling with GHS02 and GHS07 pictograms. It falls under REACH regulation requiring registration for import/manufacture above certain tonnages. The substance is not currently listed as SVHC (Substance of Very High Concern), but users must comply with workplace exposure limits and safety data sheet requirements.
Where to buy 1-chloropropane in Europe?
1-chloropropane is available through OYSI, a European distributor of chemical products specializing in high-quality industrial chemicals. OYSI provides reliable supply across Europe with proper documentation including safety data sheets and certificates of analysis. As a professional chemical distributor, OYSI ensures compliance with European regulations and offers technical support for safe handling and application guidance to industrial customers.
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Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.