1-chloro-4-methylbenzene

C7H7Cl

CAS106-43-4
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
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Identification

CAS Number
106-43-4
EC Number
203-397-0
UN Number
2238
Index Number
602-040-00-X
PubChem CID
7810

Physical-chemical properties

Molecular Formula
C7H7Cl
Molar Mass
126.58 g/mol
IUPAC Name
1-chloro-4-methylbenzene

Chemical Identifiers

InChI
InChI=1S/C7H7Cl/c1-6-2-4-7(8)5-3-6/h2-5H,1H3
InChI Key
NPDACUSDTOMAMK-UHFFFAOYSA-N

Overview

1-chloro-4-methylbenzene (CAS 106-43-4) is an aromatic organochlorine compound with selective reactivity and moderate toxicity properties. This chemical substance, also known by its IUPAC designation 1-chloro-4-methylbenzene, represents a significant intermediate in organic synthesis and industrial chemistry. With the molecular formula C7H7Cl and a molecular weight of 126.58 g/mol, this compound features a benzene ring substituted with both chlorine and methyl groups in the para position, creating a versatile building block for various chemical transformations. The compound exhibits moderate acute toxicity (Acute Tox. 4) and presents environmental concerns with chronic aquatic toxicity (Aquatic Chronic 2), requiring appropriate handling precautions as indicated by its GHS07 and GHS09 pictograms and "Warning" signal word. Its ADR Class 3 classification identifies it as a flammable liquid, necessitating proper storage and transportation protocols. In industrial applications, 1-chloro-4-methylbenzene serves primarily as an intermediate in pharmaceutical synthesis, agrochemical production, and specialty chemical manufacturing. The compound's reactivity profile makes it particularly valuable in nucleophilic substitution reactions and cross-coupling processes. Like other aromatic compounds such as 1-ethenyl-2-methylbenzene, it demonstrates the versatility of substituted benzene derivatives in synthetic chemistry, though each compound offers distinct reactivity patterns based on their specific substituents. The para-substitution pattern provides predictable reactivity and selectivity in chemical transformations, making it a preferred starting material for manufacturers requiring consistent results in multi-step synthesis processes. OYSI maintains reliable supply chains for 1-chloro-4-methylbenzene, ensuring consistent availability for European industrial customers requiring this essential chemical intermediate.

Safety & Classification

Warning
Classification:

Acute Tox. 4 *; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H332

Harmful if inhaled.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2238
ADR Class3
Packing GroupIII
Tunnel CodeD/E
Proper Shipping Name4-Chlortoluen
Marine PollutantNo

Frequently Asked Questions

What is 1-chloro-4-methylbenzene?

1-chloro-4-methylbenzene is an aromatic organochlorine compound with the molecular formula C7H7Cl and CAS number 106-43-4. This substance consists of a benzene ring substituted with a chlorine atom and a methyl group in para position. With a molecular weight of 126.58 g/mol, it belongs to the family of chlorotoluenes and is classified as moderately hazardous to health and aquatic environments.

What are the physicochemical properties of 1-chloro-4-methylbenzene?

1-chloro-4-methylbenzene is a colorless to pale yellow liquid at room temperature with a characteristic aromatic odor. It has low water solubility but is readily soluble in organic solvents such as alcohols, ethers, and hydrocarbons. The compound has a boiling point around 162°C and a density of approximately 1.07 g/cm³. It is stable under normal conditions but can be volatile.

What is 1-chloro-4-methylbenzene used for?

1-chloro-4-methylbenzene serves primarily as an intermediate in organic synthesis and pharmaceutical manufacturing. It is used in the production of dyes, agrochemicals, and specialty chemicals. The compound also finds applications in the synthesis of various aromatic compounds and as a solvent in specific industrial processes. Its reactivity makes it valuable for nucleophilic substitution reactions and other chemical transformations.

How to handle 1-chloro-4-methylbenzene safely?

Safe handling of 1-chloro-4-methylbenzene requires appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid skin and eye contact, and ensure no ignition sources are present due to its flammable nature. Always follow established safety protocols and maintain emergency equipment nearby.

How to store 1-chloro-4-methylbenzene correctly?

1-chloro-4-methylbenzene should be stored in a cool, dry, well-ventilated area away from heat sources, sparks, and open flames. Keep containers tightly sealed and upright in a designated chemical storage area. Avoid storage near incompatible materials such as strong oxidizing agents and bases. Ensure proper labeling according to GHS requirements and maintain appropriate spill containment measures in the storage area.

What to do in case of contact with 1-chloro-4-methylbenzene?

In case of skin contact with 1-chloro-4-methylbenzene, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. If eye contact occurs, flush eyes with clean water for 15 minutes while holding eyelids open. In case of inhalation, move to fresh air immediately. Seek medical attention if symptoms persist or for significant exposures.

How to dispose of 1-chloro-4-methylbenzene appropriately?

Disposal of 1-chloro-4-methylbenzene must comply with local, national, and EU waste regulations. The substance should be treated as hazardous waste and disposed of through licensed waste management companies. Never discharge into drains, soil, or water bodies due to its aquatic toxicity classification. Incineration at authorized high-temperature facilities is typically the preferred disposal method for organic chlorinated compounds.

How to transport 1-chloro-4-methylbenzene?

1-chloro-4-methylbenzene is classified under ADR transport regulations as Class 3 (flammable liquids), Packing Group III. Transportation requires appropriate packaging, labeling, and documentation according to dangerous goods regulations. Vehicles must display proper placards and carry safety equipment. Only trained personnel should handle the transport, and emergency response information must be readily available during shipment.

Is 1-chloro-4-methylbenzene subject to specific regulations?

1-chloro-4-methylbenzene is regulated under EU REACH and CLP regulations, requiring registration and proper classification. It carries GHS pictograms GHS07 and GHS09 with 'Warning' signal word, indicating moderate acute toxicity and aquatic hazard. The substance is not currently listed as SVHC (Substance of Very High Concern) but users must comply with safety data sheet requirements and exposure limits.

Where to buy 1-chloro-4-methylbenzene in Europe?

1-chloro-4-methylbenzene is available through OYSI, a specialized European distributor of chemical products. OYSI provides reliable supply with proper documentation, safety data sheets, and regulatory compliance for industrial and research applications. As an established chemical distributor, OYSI ensures quality standards and handles all necessary transport and customs requirements for European customers seeking this specialized aromatic compound.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.