1-chloro-4-methylbenzene

C7H7Cl

CAS106-43-4
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
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Identification

CAS Number
106-43-4
EC Number
203-397-0
UN Number
2238
Index Number
602-040-00-X
PubChem CID
7810

Physical-chemical properties

Molecular Formula
C7H7Cl
Molar Mass
126.58 g/mol
IUPAC Name
1-chloro-4-methylbenzene

Chemical Identifiers

InChI
InChI=1S/C7H7Cl/c1-6-2-4-7(8)5-3-6/h2-5H,1H3
InChI Key
NPDACUSDTOMAMK-UHFFFAOYSA-N

Overview

1-chloro-4-methylbenzene (CAS 106-43-4) is an aromatic chlorinated hydrocarbon with distinctive chlorine and methyl substituents on the benzene ring. This organic compound, also known by its molecular formula C7H7Cl, represents a significant member of the chlorotoluene family of chemicals. With a molecular weight of 126.58 g/mol and EC number 203-397-0, 1-chloro-4-methylbenzene exhibits the characteristic properties of halogenated aromatic compounds, making it valuable in various industrial synthesis processes. The substance presents moderate safety considerations, classified under Acute Tox. 4 and Aquatic Chronic 2 hazard categories, requiring appropriate handling protocols as indicated by its Warning signal word and GHS07/GHS09 pictograms. Its ADR Class 3 classification designates it as a flammable liquid, necessitating proper storage and transportation procedures in compliance with European chemical regulations. In industrial applications, 1-chloro-4-methylbenzene serves primarily as an intermediate in pharmaceutical synthesis, agrochemical production, and specialty chemical manufacturing. The compound's reactivity profile makes it particularly useful in nucleophilic substitution reactions and as a building block for more complex molecular structures. Its applications often overlap with related aromatic compounds such as 1-ethenyl-2-methylbenzene, which shares similar structural characteristics and synthetic utility. The chemical industry values this compound for its role in producing dyes, pigments, and various organic intermediates. Its chlorine substituent provides excellent leaving group properties for further chemical transformations, while the methyl group offers additional functionalization opportunities. OYSI maintains reliable supplies of 1-chloro-4-methylbenzene to support European industrial customers' technical and manufacturing requirements.

Safety & Classification

Warning
Classification:

Acute Tox. 4 *; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H332

Harmful if inhaled.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2238
ADR Class3
Packing GroupIII
Tunnel CodeD/E
Proper Shipping Name4-Chlortoluen
Marine PollutantNo

Frequently Asked Questions

What is 1-chloro-4-methylbenzene?

1-chloro-4-methylbenzene is an aromatic halogenated hydrocarbon with the molecular formula C7H7Cl and CAS number 106-43-4. This organic compound consists of a benzene ring substituted with a chlorine atom and a methyl group in para positions. With a molecular weight of 126.58 g/mol, it belongs to the chlorotoluene family and is classified as a moderately hazardous substance requiring proper handling precautions.

What are the physicochemical properties of 1-chloro-4-methylbenzene?

1-chloro-4-methylbenzene is a colorless to pale yellow liquid at room temperature with a characteristic aromatic odor. It has low water solubility but dissolves readily in organic solvents such as alcohols, ethers, and hydrocarbons. The compound exhibits typical properties of chlorinated aromatics including moderate volatility and stability under normal conditions, making it suitable for various industrial applications requiring controlled solvent characteristics.

What is 1-chloro-4-methylbenzene used for?

1-chloro-4-methylbenzene is primarily used as an intermediate in organic synthesis and chemical manufacturing processes. It serves as a building block for producing pharmaceuticals, agrochemicals, and specialty chemicals. The compound is also utilized in research laboratories for synthetic chemistry applications and as a solvent in specific industrial processes where its aromatic and halogenated properties are beneficial for reaction outcomes.

How to handle 1-chloro-4-methylbenzene safely?

1-chloro-4-methylbenzene requires careful handling due to its Acute Tox. 4 classification. Always wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Ensure adequate ventilation to prevent vapor accumulation and avoid skin and eye contact. Work in well-ventilated areas or under fume hoods, and have emergency eyewash stations readily available. Follow proper hygiene practices and avoid eating, drinking, or smoking in work areas.

How to store 1-chloro-4-methylbenzene correctly?

1-chloro-4-methylbenzene should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Keep containers upright and protected from physical damage. Store away from incompatible materials such as strong oxidizing agents and bases. Ensure storage areas have appropriate fire prevention measures and spill containment systems. Maintain storage temperatures within recommended ranges to prevent degradation.

What to do in case of contact with 1-chloro-4-methylbenzene?

1-chloro-4-methylbenzene exposure requires immediate action depending on the route of contact. For skin contact, remove contaminated clothing and wash thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for at least 15 minutes and seek medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical assistance while providing safety data sheet information.

How to dispose of 1-chloro-4-methylbenzene properly?

1-chloro-4-methylbenzene disposal must comply with local and national hazardous waste regulations due to its environmental classification as Aquatic Chronic 2. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Do not discharge into sewers, waterways, or soil. Small quantities may require specialized incineration at high temperatures with appropriate emission controls. Always consult local environmental authorities for specific disposal requirements and documentation.

How to transport 1-chloro-4-methylbenzene?

1-chloro-4-methylbenzene is classified as ADR Class 3 (flammable liquids), Packing Group III for transportation purposes. It requires appropriate UN specification packaging and hazard labeling during transport. Vehicles must carry proper documentation including transport documents and emergency response information. Drivers need ADR training certification, and transport routes should avoid populated areas when possible. Ensure compliance with international dangerous goods regulations for cross-border shipments.

Is 1-chloro-4-methylbenzene subject to specific regulations?

1-chloro-4-methylbenzene is regulated under European REACH and CLP regulations requiring proper registration, classification, and safety data sheet provision. It is not currently listed as a Substance of Very High Concern (SVHC). Companies must comply with occupational exposure limits, environmental discharge restrictions, and proper hazard communication requirements. Regular monitoring and risk assessments may be required depending on usage volumes and applications in industrial settings.

Where to buy 1-chloro-4-methylbenzene in Europe?

1-chloro-4-methylbenzene is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides reliable supply with proper documentation, safety data sheets, and regulatory compliance support across European markets. As a professional chemical distributor, OYSI ensures product quality, appropriate packaging, and technical support for industrial customers requiring this specialty aromatic compound for their manufacturing and research applications.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.