Tetraoxoosmium

O4Os

tetraoxoosmium

CAS20816-12-0
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
Danger

Consulting for Tetraoxoosmium

Our experts support you with application, dosage, and compliance.

Request Consultation

Identification

CAS Number
20816-12-0
EC Number
244-058-7
UN Number
2471
Index Number
076-001-00-5
PubChem CID
30318

Physical-chemical properties

Molecular Formula
O4Os
Molar Mass
254.20 g/mol
IUPAC Name
tetraoxoosmium

Chemical Identifiers

InChI
InChI=1S/4O.Os
InChI Key
VUVGYHUDAICLFK-UHFFFAOYSA-N

Overview

Tetraoxoosmium (CAS 20816-12-0) is an osmium tetroxide compound with exceptional toxicity and strong oxidizing properties that make it extremely hazardous to handle. This inorganic compound, with molecular formula O4Os and molecular weight 254.2 g/mol, represents one of the most dangerous osmium compounds encountered in industrial applications. Tetraoxoosmium appears as a pale yellow crystalline solid that exhibits remarkable volatility, readily subliming at room temperature to produce highly toxic vapors. The compound's extreme hazard profile is reflected in its classification under multiple acute toxicity categories, including Acute Tox. 1 and Acute Tox. 2, along with skin corrosion properties (Skin Corr. 1B), necessitating the "Danger" signal word and both skull-and-crossbones (GHS06) and corrosion (GHS05) pictograms. The substance's chemical behavior is characterized by its powerful oxidizing nature, making it reactive with organic materials and requiring specialized storage under ADR class 6.1 transport regulations. Unlike less reactive compounds such as chloromethylbenzene, tetraoxoosmium demands extreme caution in handling due to its ability to cause severe tissue damage through both contact and inhalation exposure. Its volatility at ambient conditions creates additional risks not typically associated with solid oxidizing agents. Primary industrial applications include use as a specialized staining agent in electron microscopy for biological specimens, catalyst precursor in certain organic synthesis reactions, and analytical reagent for trace metal determinations. These applications leverage its unique oxidizing properties while requiring stringent safety protocols. OYSI maintains availability of tetraoxoosmium for qualified industrial customers with appropriate handling capabilities and safety infrastructure.

Safety & Classification

Danger
Classification:

Acute Tox. 2 *; Acute Tox. 1; Acute Tox. 2 *; Skin Corr. 1B

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H330

Fatal if inhaled.

H310

Fatal in contact with skin.

H300

Fatal if swallowed.

H314

Causes severe skin burns and eye damage.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Fatal

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Fatal

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Fatal

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2471
ADR Class6.1
Packing GroupI
Tunnel CodeC/E
Proper Shipping NameOsmiumtetroxid, fest
Marine PollutantNo

Frequently Asked Questions

What is tetraoxoosmium?

Tetraoxoosmium is a highly toxic osmium compound with the chemical formula O4Os and CAS number 20816-12-0. This inorganic substance has a molecular weight of 254.2 g/mol and represents one of the most dangerous osmium oxides. It is classified as extremely hazardous with multiple acute toxicity categories and corrosive properties, requiring specialized handling procedures and safety measures in industrial applications.

What are the physicochemical properties of tetraoxoosmium?

Tetraoxoosmium is a volatile crystalline solid that appears as pale yellow crystals at room temperature. It exhibits high volatility and can sublime readily, producing toxic vapors. The compound is moderately soluble in water and organic solvents, with a characteristic pungent odor. Its high vapor pressure makes it particularly dangerous, as it can easily contaminate air and pose inhalation hazards.

What is tetraoxoosmium used for?

Tetraoxoosmium is primarily used as a powerful oxidizing agent in specialized chemical synthesis and analytical chemistry applications. It serves as a staining agent in electron microscopy for biological specimens and as a catalyst in certain organic transformations. Due to its extreme toxicity, its use is limited to highly controlled laboratory environments and specialized industrial processes requiring expert handling.

How to handle tetraoxoosmium safely?

Tetraoxoosmium requires extreme safety precautions including full respiratory protection, chemical-resistant gloves, and protective clothing due to its Acute Tox. 1-2 and Skin Corr. 1B classifications. Work must be conducted in well-ventilated fume hoods or enclosed systems. Personnel must be trained in emergency procedures, and exposure monitoring is essential. Never handle without proper PPE, and ensure emergency shower facilities are readily accessible.

How to store tetraoxoosmium correctly?

Tetraoxoosmium must be stored in tightly sealed, corrosion-resistant containers in a cool, dry, well-ventilated area away from incompatible materials. Storage areas should be equipped with appropriate containment systems and restricted access. Due to its volatile nature and extreme toxicity, quantities should be minimized, and containers must be regularly inspected for integrity. Segregate from reducing agents and organic materials.

What to do in case of contact with tetraoxoosmium?

Immediate action is critical due to tetraoxoosmium's extreme toxicity and corrosive properties. For skin contact, remove contaminated clothing and flush with copious amounts of water for at least 15 minutes. If inhaled, move to fresh air immediately and seek medical attention. For eye contact, irrigate continuously with water. In all cases, obtain immediate medical attention and provide safety data sheet to medical personnel.

How to dispose of tetraoxoosmium appropriately?

Tetraoxoosmium disposal requires specialized hazardous waste procedures due to its extreme toxicity classification. It must be disposed of through licensed hazardous waste contractors following local and EU regulations. Never pour down drains or dispose of in regular waste. Containers must be properly labeled, and disposal documentation must be maintained. Contact specialized chemical waste management companies for safe collection and treatment.

How to transport tetraoxoosmium?

Tetraoxoosmium is classified as ADR Class 6.1 (toxic substances) Packing Group I, indicating maximum danger level during transport. It requires specialized packaging, proper labeling with GHS06 and GHS05 pictograms, and transport documents. Only authorized carriers experienced with highly toxic materials should handle shipments. Vehicles must be properly equipped, and drivers must have appropriate training and certification for dangerous goods transport.

Is tetraoxoosmium subject to specific regulations?

Tetraoxoosmium is subject to strict European regulations under REACH and CLP due to its extreme toxicity profile. While not currently listed as an SVHC, it requires safety data sheets, proper classification labeling, and may be subject to authorization or restriction procedures. Users must comply with occupational exposure limits, worker protection regulations, and environmental discharge restrictions across EU member states.

Where to buy tetraoxoosmium in Europe?

Tetraoxoosmium is available through specialized chemical distributors like OYSI, which serves the European market with high-purity laboratory and industrial chemicals. Due to its extreme hazard classification, purchase typically requires verification of proper handling facilities, trained personnel, and legitimate research or industrial applications. Contact OYSI's technical team for availability, specifications, and regulatory compliance support for your specific requirements.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.