Tetraoxoosmium

O4Os

tetraoxoosmium

CAS20816-12-0
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
Danger

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Identification

CAS Number
20816-12-0
EC Number
244-058-7
UN Number
2471
Index Number
076-001-00-5
PubChem CID
30318

Physical-chemical properties

Molecular Formula
O4Os
Molar Mass
254.20 g/mol
IUPAC Name
tetraoxoosmium

Chemical Identifiers

InChI
InChI=1S/4O.Os
InChI Key
VUVGYHUDAICLFK-UHFFFAOYSA-N

Overview

Tetraoxoosmium (CAS 20816-12-0) is a highly toxic osmium oxide compound with exceptional oxidizing properties and extreme corrosivity. This inorganic compound, with the molecular formula O4Os and a molecular weight of 254.2 g/mol, represents one of the most hazardous osmium compounds encountered in industrial chemistry. Also known by its EC number 244-058-7, tetraoxoosmium exhibits remarkable volatility at room temperature, forming dangerous vapors that pose severe health risks. The compound's classification under multiple acute toxicity categories (Acute Tox. 1 and Acute Tox. 2) alongside its skin corrosion properties (Skin Corr. 1B) underscores its extremely dangerous nature. The substance's hazard profile necessitates stringent safety protocols, as indicated by its GHS06 and GHS05 pictogrammes and "Danger" signal word. Its ADR Class 6.1 classification reflects the serious toxic risks associated with transportation and handling. Unlike less hazardous compounds such as chloromethylbenzene, tetraoxoosmium requires specialized containment systems and expert handling procedures due to its volatile and corrosive characteristics. Primary industrial applications include specialized catalytic processes, particularly in organic synthesis where its powerful oxidizing capabilities are essential. The compound also finds use in advanced materials research and certain analytical chemistry procedures. Additionally, it serves as a precursor for other osmium-based compounds in specialized chemical manufacturing processes. Given the compound's extreme hazard profile and specialized applications, proper risk assessment and regulatory compliance are paramount. OYSI provides access to tetraoxoosmium for qualified industrial customers with appropriate safety infrastructure and technical expertise.

Safety & Classification

Danger
Classification:

Acute Tox. 2 *; Acute Tox. 1; Acute Tox. 2 *; Skin Corr. 1B

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H330

Fatal if inhaled.

H310

Fatal in contact with skin.

H300

Fatal if swallowed.

H314

Causes severe skin burns and eye damage.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Fatal

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Fatal

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Fatal

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2471
ADR Class6.1
Packing GroupI
Tunnel CodeC/E
Proper Shipping NameOsmiumtetroxid, fest
Marine PollutantNo

Frequently Asked Questions

What is tetraoxoosmium?

Tetraoxoosmium is an inorganic chemical compound with the molecular formula O4Os and CAS number 20816-12-0. This osmium oxide has a molecular weight of 254.2 g/mol and represents one of the highest oxidation states of osmium. It is classified as an extremely hazardous substance with multiple acute toxicity classifications and corrosive properties, requiring strict safety protocols for handling and storage.

What are the physicochemical properties of tetraoxoosmium?

Tetraoxoosmium is a volatile crystalline solid that typically appears as pale yellow crystals at room temperature. It has a distinctive pungent, chlorine-like odor and is highly soluble in water, forming osmium tetroxide solutions. The compound is thermally unstable and can decompose upon heating. Its high volatility makes it particularly dangerous as it can easily form toxic vapors at ambient temperatures.

What is tetraoxoosmium used for?

Tetraoxoosmium serves primarily as a powerful oxidizing agent in organic synthesis and as a staining agent in electron microscopy for biological samples. It is used in the pharmaceutical industry for specific oxidation reactions and in materials science for surface treatments. Due to its extreme toxicity and regulatory restrictions, its applications are limited to specialized laboratory and industrial processes requiring expert handling.

How to handle tetraoxoosmium safely?

Tetraoxoosmium requires extreme safety precautions due to its Acute Tox. 1 and Skin Corr. 1B classifications. Always work in a well-ventilated fume hood with full personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Respiratory protection is mandatory. Handle only minimal quantities and ensure emergency procedures are established. Never allow direct skin contact or inhalation of vapors.

How to store tetraoxoosmium correctly?

Tetraoxoosmium must be stored in a cool, dry, well-ventilated area away from incompatible materials such as organic compounds and reducing agents. Use tightly sealed, chemically resistant containers and store in a designated hazardous materials storage area with appropriate warning signs. Maintain temperature control to minimize vapor formation and ensure storage areas are equipped with emergency response equipment and eyewash stations.

What to do in case of contact with tetraoxoosmium?

Tetraoxoosmium exposure requires immediate emergency response due to its corrosive and highly toxic nature. For skin contact, immediately flush with copious amounts of water for at least 15 minutes and remove contaminated clothing. For eye contact, rinse continuously with water and seek immediate medical attention. If inhaled, move to fresh air immediately. In all cases, contact emergency medical services and poison control centers without delay.

How to dispose of tetraoxoosmium appropriately?

Tetraoxoosmium disposal requires specialized hazardous waste management procedures due to its classification as ADR Class 6.1, Group I material. Contact certified hazardous waste disposal companies for proper treatment and disposal. Never dispose of in regular waste streams or pour down drains. All containers and contaminated materials must be treated as hazardous waste and disposed of according to local environmental regulations and waste management protocols.

How to transport tetraoxoosmium?

Tetraoxoosmium is classified under ADR Class 6.1 (toxic substances), Packing Group I, indicating maximum danger level for transport. It requires specialized packaging, labeling with GHS06 and GHS05 pictograms, and documentation compliant with dangerous goods regulations. Only authorized carriers with proper training and equipment can transport this substance. Ensure proper emergency response information accompanies all shipments and follow strict quantity limitations.

Is tetraoxoosmium subject to specific regulations?

Tetraoxoosmium is subject to extensive chemical regulations including REACH registration requirements and CLP classification obligations in Europe. Its classification as Acute Tox. 1 and corrosive substance triggers strict labeling, safety data sheet, and notification requirements. Although not listed as an SVHC substance, its extreme toxicity may subject it to additional national restrictions and import/export controls requiring special permits.

Where to buy tetraoxoosmium in Europe?

Tetraoxoosmium is available through specialized chemical distributors like OYSI, which serves the European market with high-purity chemicals for professional applications. Due to its extreme hazard classification and regulatory requirements, purchase is typically restricted to qualified industrial users and research institutions. Buyers must demonstrate proper safety protocols, storage facilities, and regulatory compliance before procurement can be approved.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.