Tert-butyl 2-(triphenyl-lambda5-phosphanylidene)acetate

Tert-butyl 2-(triphenyl-lambda5-phosphanylidene)acetate is an organophosphorus compound with the molecular formula C24H25O2P and CAS number 35000-38-5. This chemical substance has a molecular weight of 376.4 g/mol and belongs to the class of phosphonium ylides. It is classified as a dangerous substance requiring careful handling due to its acute toxicity and potential for causing specific target organ toxicity through repeated exposure.

Tert-butyl 2-(triphenyl-lambda5-phosphanylidene)acetate is a solid organophosphorus compound at room temperature with a molecular weight of 376.4 g/mol. The substance contains both aromatic triphenylphosphine groups and aliphatic tert-butyl ester functionality. Its exact physical appearance, solubility, and stability characteristics should be confirmed through technical specifications, as these properties can vary depending on purity and crystalline form.

Tert-butyl 2-(triphenyl-lambda5-phosphanylidene)acetate is primarily used as a reagent in organic synthesis, particularly in Wittig-type reactions for carbon-carbon bond formation. This phosphonium ylide serves as an important intermediate in pharmaceutical and fine chemical manufacturing. It enables the formation of alkenes through reaction with carbonyl compounds, making it valuable in the synthesis of complex organic molecules in research and industrial applications.

Tert-butyl 2-(triphenyl-lambda5-phosphanylidene)acetate requires careful handling due to its Acute Tox. 3 classification and skin sensitization potential. Essential safety measures include wearing appropriate personal protective equipment such as chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid skin and eye contact, and ensure personnel are trained in proper handling procedures for toxic substances.

Tert-butyl 2-(triphenyl-lambda5-phosphanylidene)acetate should be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from heat sources and incompatible materials. The storage area must be secure and accessible only to authorized personnel due to its toxic classification. Containers should be properly labeled with hazard information, and storage conditions should prevent degradation while minimizing exposure risks to personnel and the environment.

In case of skin contact with tert-butyl 2-(triphenyl-lambda5-phosphanylidene)acetate, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, rinse immediately with plenty of clean water for 15 minutes and seek medical attention. If inhaled, move the person to fresh air and seek medical advice if symptoms persist. Always consult safety data sheets for complete first aid procedures.

Tert-butyl 2-(triphenyl-lambda5-phosphanylidene)acetate must be disposed of according to local, national, and international regulations for hazardous waste. This toxic substance cannot be disposed of with regular waste and requires specialized hazardous waste treatment facilities. Contact licensed waste disposal companies experienced in handling organophosphorus compounds. Ensure all containers are properly labeled and documented for waste tracking compliance with environmental regulations.

Tert-butyl 2-(triphenyl-lambda5-phosphanylidene)acetate is classified under ADR Class 6.1 (toxic substances), Packing Group II, indicating significant toxicity requiring special transport precautions. Transportation must comply with dangerous goods regulations including proper packaging, labeling with appropriate hazard pictogrammes (GHS06, GHS08, GHS09), and documentation. Only certified carriers authorized to transport Class 6.1 substances should handle shipments, following all applicable ADR transport requirements.

Tert-butyl 2-(triphenyl-lambda5-phosphanylidene)acetate is subject to REACH registration requirements and CLP classification regulations in Europe. The substance is classified with hazard classes including Acute Tox. 3, STOT RE 2, Eye Irrit. 2, Skin Sens. 1, and Aquatic Chronic 2, requiring compliance with corresponding labeling and safety requirements. While not currently listed as an SVHC, users must comply with all applicable chemical safety legislation and workplace exposure limits.

Tert-butyl 2-(triphenyl-lambda5-phosphanylidene)acetate is available through OYSI, a specialized European distributor of chemical products with expertise in organophosphorus compounds. OYSI provides reliable supply chains across Europe with proper documentation, safety data sheets, and regulatory compliance support. As an established chemical distributor, OYSI ensures quality products meeting European standards while providing technical support for safe handling and application of this specialized reagent.