N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide

C14H14ClNO3

CAS69581-33-5
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
69581-33-5
EC Number
274-050-9
UN Number
2761
Index Number
616-033-00-4
PubChem CID
50590

Physical-chemical properties

Molecular Formula
C14H14ClNO3
Molar Mass
279.72 g/mol
IUPAC Name
N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide

Chemical Identifiers

InChI
InChI=1S/C14H14ClNO3/c15-10-2-1-3-11(8-10)16(13(17)9-4-5-9)12-6-7-19-14(12)18/h1-3,8-9,12H,4-7H2
InChI Key
KRZUZYJEQBXUIN-UHFFFAOYSA-N

Overview

N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide (CAS 69581-33-5) is an organochlorine amide compound with notable toxicological properties and environmental persistence. This specialized chemical compound features a complex molecular structure combining a chlorinated phenyl ring, a cyclopropane carboxamide group, and an oxooxolane moiety, resulting in the molecular formula C14H14ClNO3 with a molecular weight of 279.72 g/mol. The European Chemical Agency has assigned it the EC number 274-050-9, reflecting its registration under REACH regulations for industrial use within the European market. The compound exhibits significant safety considerations, classified under multiple acute toxicity categories (Acute Tox. 3 and 4) and carries the "Danger" signal word with corresponding GHS06 and GHS09 pictograms. Its environmental profile shows particular concern for aquatic ecosystems, with classifications as Aquatic Acute 1 and Aquatic Chronic 1, indicating both immediate and long-term hazards to marine life. Transportation falls under ADR Class 6.1, designating it as a toxic substance requiring specialized handling protocols. Industrial applications typically involve its use as an intermediate in pharmaceutical synthesis and specialized chemical manufacturing processes. The compound's unique structural features make it valuable in research applications, particularly in studies involving cyclopropane-containing molecules. Similar to other complex organochlorine compounds like 4-[2-(4-tert-butylphenyl)ethoxy]quinazoline, it requires careful handling and environmental monitoring throughout its lifecycle. Due to its toxicological profile and environmental persistence, applications often focus on controlled synthetic pathways where its specific chemical properties provide advantages over alternative reagents. OYSI maintains this compound in its technical chemical portfolio for qualified industrial customers requiring specialized organic intermediates.

Safety & Classification

Danger
Classification:

Acute Tox. 4 *; Acute Tox. 3 *; Aquatic Acute 1; Aquatic Chronic 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H312

Harmful in contact with skin.

H301

Toxic if swallowed.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2761
ADR Class6.1
Packing GroupIII
Tunnel CodeE
Proper Shipping NameCyprofuram (ISO)
Marine PollutantNo

Frequently Asked Questions

What is N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide?

N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide is an organic chemical compound with the molecular formula C14H14ClNO3 and CAS number 69581-33-5. This compound has a molecular weight of 279.72 g/mol and contains a cyclopropanecarboxamide functional group linked to a chlorinated phenyl ring and an oxooxolan moiety. It is classified as a hazardous substance with acute toxicity properties and environmental hazard classifications.

What are the physico-chemical properties of N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide?

N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide has a molecular weight of 279.72 g/mol and molecular formula C14H14ClNO3. As an organic compound containing both aromatic and cyclic structures, it likely exists as a solid under standard conditions. The presence of the chlorophenyl group and oxooxolan ring influences its polarity and solubility characteristics, though specific physical properties would require detailed analytical characterization.

What is N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide used for?

N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide is typically used in specialized chemical applications, potentially as an intermediate in pharmaceutical synthesis or research applications. Given its complex molecular structure containing cyclopropane and oxooxolan moieties, it may serve as a building block in organic synthesis or medicinal chemistry research. Specific industrial applications would depend on the compound's biological activity and chemical reactivity profile.

How to handle N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide safely?

Safe handling of N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide requires appropriate personal protective equipment due to its Acute Tox. 4 and Acute Tox. 3 classifications. Use chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume extraction systems. Avoid inhalation, ingestion, and skin contact. Follow the safety data sheet guidelines and ensure proper training before handling this hazardous material.

How to store N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide correctly?

N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide should be stored in a cool, dry, well-ventilated area away from incompatible materials. Keep containers tightly closed and properly labeled according to GHS requirements with GHS06 and GHS09 pictograms. Store away from heat sources, direct sunlight, and moisture. Due to its acute toxicity classification, ensure secure storage with restricted access and appropriate warning signage.

What to do in case of contact with N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide?

In case of contact with N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide, immediate action is required due to its acute toxicity. For skin contact, remove contaminated clothing and rinse thoroughly with water. For eye contact, flush immediately with water for at least 15 minutes. If inhaled, move to fresh air. If ingested, do not induce vomiting. Seek immediate medical attention in all cases and provide the safety data sheet to medical personnel.

How to dispose of N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide appropriately?

N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide must be disposed of as hazardous waste according to local, national, and EU regulations. Due to its acute toxicity and environmental hazard classifications (Aquatic Acute 1, Aquatic Chronic 1), it cannot be disposed of in regular waste streams. Contact licensed hazardous waste disposal companies and follow the waste classification codes specified in your region's hazardous waste regulations.

How to transport N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide?

N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide is classified under ADR Class 6.1 (toxic substances), Packing Group III for transportation. It requires appropriate UN-specification packaging marked with the correct UN number and hazard labels. Transport documentation must include proper shipping names and hazard information. Only trained personnel should handle the transport, and emergency response information must be available during transit according to ADR regulations.

Is N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide subject to specific regulations?

N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide is subject to REACH and CLP regulations in the European Union. It is not currently listed as a Substance of Very High Concern (SVHC). The compound must be classified and labeled according to CLP with 'Danger' signal word and appropriate GHS pictograms (GHS06, GHS09). Users must comply with occupational safety regulations and environmental protection requirements due to its toxicity and aquatic hazard classifications.

Where to buy N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide in Europe?

N-(3-chlorophenyl)-N-(2-oxooxolan-3-yl)cyclopropanecarboxamide is available through OYSI, a specialized European distributor of technical chemicals. As a professional chemical supplier, OYSI can provide this compound with appropriate documentation including safety data sheets, certificates of analysis, and regulatory compliance information. Contact OYSI directly for availability, specifications, and technical support for your specific application requirements in research or industrial processes.

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Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.