Cyclopropane

C3H6

cyclopropane

CAS75-19-4
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS04 Gefahrensymbol: Unter Druck stehende Gase – Gasflasche
Danger

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Identification

CAS Number
75-19-4
EC Number
200-847-8
UN Number
1027
Index Number
601-016-00-6
PubChem CID
6351

Physical-chemical properties

Molecular Formula
C3H6
Molar Mass
42.08 g/mol
IUPAC Name
cyclopropane

Chemical Identifiers

InChI
InChI=1S/C3H6/c1-2-3-1/h1-3H2
InChI Key
LVZWSLJZHVFIQJ-UHFFFAOYSA-N

Overview

Cyclopropane (CAS 75-19-4) is a highly strained three-membered saturated hydrocarbon ring with exceptional reactivity and flammability properties. This smallest cycloalkane represents a unique class of organic compounds characterized by significant ring strain due to its triangular geometry, where carbon-carbon bond angles deviate substantially from the ideal tetrahedral angle. With the molecular formula C3H6 and a molecular weight of 42.08 g/mol, cyclopropane exists as a colorless gas under standard conditions, sharing the same molecular formula with linear alkenes such as prop-1-ene, though exhibiting markedly different chemical behavior due to its cyclic structure. The compound's distinctive three-membered ring configuration results in considerable angle strain, making cyclopropane significantly more reactive than its linear counterparts or larger cycloalkanes. This inherent instability drives various ring-opening reactions, particularly under thermal or catalytic conditions. Safety considerations are paramount when handling cyclopropane, as it is classified as a flammable gas (Flam. Gas 1) and pressurized gas (Press. Gas) under the GHS classification system, requiring appropriate storage and handling protocols in inert atmospheres. Industrial applications of cyclopropane primarily focus on synthetic organic chemistry, where it serves as a valuable building block for pharmaceutical intermediates and specialty chemicals. The compound finds particular utility in cyclopropanation reactions and as a precursor for synthesizing more complex cyclic structures. Additionally, cyclopropane has historical significance in medical applications, though its use has largely been superseded by safer alternatives. OYSI provides high-quality cyclopropane with comprehensive technical documentation and safety data sheets to support your industrial chemical requirements across European markets.

Safety & Classification

Danger
Classification:

Flam. Gas 1; Press. Gas

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H220

Extremely flammable gas.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Transport (ADR)

UN Number1027
ADR Class2
Packing Group
Tunnel CodeB/D
Proper Shipping NameCyclopropan, unter Druck verflüssigt
Marine PollutantNo

Frequently Asked Questions

What is cyclopropane?

Cyclopropane is a highly flammable cyclic hydrocarbon with the molecular formula C3H6 and CAS number 75-19-4. This three-membered ring compound has a molecular weight of 42.08 g/mol and exists as a colorless gas under normal conditions. Due to its unique ring strain structure, cyclopropane exhibits distinctive chemical properties and reactivity patterns that make it valuable in various industrial applications.

What are the physicochemical properties of cyclopropane?

Cyclopropane is a colorless gas at room temperature with a characteristic sweet odor. It has a boiling point of -32.8°C and a melting point of -127.6°C. The compound is sparingly soluble in water but readily dissolves in organic solvents. Its three-membered ring structure creates significant ring strain, making it more reactive than other cycloalkanes and contributing to its flammable nature.

What is cyclopropane used for?

Cyclopropane is primarily used as an intermediate in organic synthesis and pharmaceutical manufacturing. It serves as a building block for producing various cyclopropyl-containing compounds, including pharmaceuticals, agrochemicals, and specialty chemicals. Historically, it was used as an anesthetic agent, though this application has largely been discontinued due to safety concerns. Today, it finds applications in research laboratories and specialized chemical synthesis processes.

How to handle cyclopropane safely?

Cyclopropane must be handled with extreme caution due to its classification as a flammable gas (Flam. Gas 1). Always work in well-ventilated areas away from ignition sources, sparks, and hot surfaces. Use appropriate personal protective equipment including safety glasses, flame-resistant clothing, and ensure proper grounding of equipment. Install gas detection systems and have emergency procedures in place. Never smoke or use open flames in areas where cyclopropane is handled.

How to store cyclopropane correctly?

Cyclopropane should be stored in approved pressure vessels designed for compressed gases in cool, dry, well-ventilated areas away from heat sources and ignition points. Storage areas must be equipped with appropriate ventilation systems and gas detection equipment. Keep containers upright and secure to prevent falling. Ensure storage temperatures remain below 50°C and maintain proper segregation from incompatible materials such as oxidizing agents and strong acids.

What to do in case of contact with cyclopropane?

Cyclopropane exposure requires immediate action depending on the route of contact. In case of inhalation, move the person to fresh air immediately and seek medical attention if breathing difficulties occur. For skin contact, remove contaminated clothing and flush with water. In case of gas leak, evacuate the area, eliminate ignition sources, and ventilate the space. Always contact emergency services if significant exposure occurs or if symptoms develop.

How to dispose of cyclopropane properly?

Cyclopropane disposal must comply with local environmental regulations and waste management requirements. Contact licensed waste disposal companies specialized in hazardous gas handling for proper disposal. Never release cyclopropane directly into the atmosphere or sewer systems. Empty containers should be depressurized safely and handled according to local regulations. Consult with environmental authorities and follow established protocols for flammable gas waste disposal in your jurisdiction.

How to transport cyclopropane?

Cyclopropane is classified under ADR Class 2 (Gases) for transportation purposes. It must be transported in approved pressure vessels designed for compressed gases, following UN packaging requirements. Vehicles must display appropriate hazard placards and carry emergency response information. Drivers require ADR certification for dangerous goods transport. Ensure proper documentation, avoid heat sources during transport, and follow routing restrictions for flammable gases through populated areas.

Is cyclopropane subject to particular regulations?

Cyclopropane is subject to various European regulations including CLP (Classification, Labelling and Packaging) requirements as a flammable gas with danger signal word and GHS02/GHS04 pictograms. It falls under REACH registration requirements for commercial use. The substance is not currently listed as an SVHC (Substance of Very High Concern). Additional national regulations may apply regarding storage, handling, and workplace exposure limits in different European countries.

Where to buy cyclopropane in Europe?

Cyclopropane is available through specialized chemical distributors across Europe, including OYSI, a trusted European distributor of technical chemicals. When sourcing cyclopropane, ensure suppliers provide proper documentation, safety data sheets, and comply with transportation regulations for compressed gases. Due to its hazardous nature, purchases typically require appropriate licenses and safety certifications. Contact OYSI for availability, specifications, and delivery options tailored to your specific requirements.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.