Methyl 2-chlorosulfonyl-4-(methanesulfonamidomethyl)benzoate

Methyl 2-chlorosulfonyl-4-(methanesulfonamidomethyl)benzoate is a specialized organic compound with the molecular formula C10H12ClNO6S2 and CAS number 393509-79-0. This chemical features a benzoate ester backbone with chlorosulfonyl and methanesulfonamidomethyl substituents, giving it unique reactivity properties. With a molecular weight of 341.8 g/mol, it belongs to the class of sulfonyl chlorides and is classified as hazardous due to its potential for severe eye damage and chronic aquatic toxicity.

Methyl 2-chlorosulfonyl-4-(methanesulfonamidomethyl)benzoate is an organic solid compound with a molecular weight of 341.8 g/mol. The presence of both hydrophilic sulfonyl groups and hydrophobic aromatic structures suggests limited water solubility. The chlorosulfonyl functional group makes it highly reactive toward nucleophiles, particularly water and alcohols. The compound's stability and exact physical appearance depend on storage conditions and purity, but it should be handled as a moisture-sensitive material due to the reactive chlorosulfonyl group.

Methyl 2-chlorosulfonyl-4-(methanesulfonamidomethyl)benzoate is primarily used as an intermediate in pharmaceutical synthesis and fine chemical manufacturing. The chlorosulfonyl group serves as a reactive handle for introducing sulfonamide linkages, making it valuable in drug development. It may also find applications in the synthesis of specialty polymers, agrochemicals, or as a building block for more complex organic molecules. Its dual functionality allows for selective chemical modifications in multi-step synthetic processes.

Methyl 2-chlorosulfonyl-4-(methanesulfonamidomethyl)benzoate must be handled with appropriate personal protective equipment including safety goggles, chemical-resistant gloves, and protective clothing due to its Eye Dam. 1 classification. Work should be conducted in a well-ventilated area or under a fume hood to prevent inhalation exposure. Avoid contact with water or moisture as the chlorosulfonyl group is highly reactive. Use non-sparking tools and ensure proper grounding when handling to prevent static discharge.

Methyl 2-chlorosulfonyl-4-(methanesulfonamidomethyl)benzoate should be stored in a cool, dry place away from moisture and incompatible materials. The container must be tightly sealed and made of compatible materials resistant to corrosion. Keep away from water, alcohols, amines, and other nucleophilic substances that can react with the chlorosulfonyl group. Store in a well-ventilated area away from heat sources and direct sunlight. Ensure proper labeling with hazard symbols and maintain an inventory record for regulatory compliance.

Immediate action is required in case of contact with methyl 2-chlorosulfonyl-4-(methanesulfonamidomethyl)benzoate due to its severe eye damage potential. For eye contact, rinse immediately with plenty of water for at least 15 minutes and seek immediate medical attention. For skin contact, remove contaminated clothing and wash thoroughly with soap and water. If inhaled, move to fresh air and seek medical advice if symptoms persist. Never induce vomiting if ingested; rinse mouth and seek immediate medical attention while providing the safety data sheet to medical personnel.

Methyl 2-chlorosulfonyl-4-(methanesulfonamidomethyl)benzoate must be disposed of through authorized hazardous waste disposal services in accordance with local and European regulations. The substance cannot be discharged to sewers or the environment due to its aquatic toxicity classification. Contaminated containers and materials should be treated as hazardous waste. Small quantities may require neutralization under controlled conditions before disposal, but this should only be performed by qualified personnel. Always consult local environmental authorities for specific disposal requirements.

Methyl 2-chlorosulfonyl-4-(methanesulfonamidomethyl)benzoate is classified as ADR Class 8 (corrosive substances), Packing Group III for transportation purposes. It must be packaged in UN-approved containers with appropriate markings and labels including the corrosive hazard symbol (GHS05). Transport documents must include the proper shipping name, UN number, and hazard class. Vehicles must carry appropriate emergency equipment and drivers require ADR certification. Ensure packages are secured to prevent damage during transit and avoid exposure to moisture or extreme temperatures.

Methyl 2-chlorosulfonyl-4-(methanesulfonamidomethyl)benzoate is subject to various European chemical regulations including CLP for classification and labeling, requiring Danger signal word and GHS05/GHS09 pictograms. REACH registration may be required depending on import/manufacturing volumes. It is not currently listed as a Substance of Very High Concern (SVHC). Transport is regulated under ADR as a Class 8 corrosive substance. Users must maintain safety data sheets and ensure compliance with workplace safety regulations including appropriate risk assessments and worker protection measures.

Methyl 2-chlorosulfonyl-4-(methanesulfonamidomethyl)benzoate is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides this compound to pharmaceutical companies, research institutions, and fine chemical manufacturers across Europe with proper documentation including certificates of analysis and safety data sheets. As a regulated substance requiring specialized handling and storage, it is typically available through established chemical supply chains with appropriate hazardous material handling capabilities and regulatory compliance support.