Ethyl 5,5-diphenyl-4H-1,2-oxazole-3-carboxylate

Ethyl 5,5-diphenyl-4H-1,2-oxazole-3-carboxylate is an organic chemical compound with the molecular formula C18H17NO3 and CAS number 163520-33-0. This oxazole derivative features a five-membered heterocyclic ring containing nitrogen and oxygen, with two phenyl groups and an ethyl ester functional group. With a molecular weight of 295.3 g/mol, it belongs to the class of substituted oxazoles used in organic synthesis and pharmaceutical research.

Ethyl 5,5-diphenyl-4H-1,2-oxazole-3-carboxylate is a solid organic compound at room temperature with a molecular weight of 295.3 g/mol. The compound contains aromatic phenyl rings and an ester group, which typically confer moderate solubility in organic solvents like ethanol, acetone, and dichloromethane, while having limited water solubility. The presence of the oxazole ring and phenyl substituents contributes to its chemical stability under normal conditions.

Ethyl 5,5-diphenyl-4H-1,2-oxazole-3-carboxylate is primarily used as an intermediate in organic synthesis and pharmaceutical research. The oxazole framework serves as a building block for developing bioactive compounds, including potential pharmaceuticals and agrochemicals. Its structural features make it valuable for medicinal chemistry applications, particularly in the synthesis of heterocyclic compounds with biological activity. It may also be used in academic research for studying oxazole chemistry and reaction mechanisms.

Ethyl 5,5-diphenyl-4H-1,2-oxazole-3-carboxylate requires careful handling due to its Acute Tox. 4 and Skin Sens. 1 classifications. Always wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and lab coats. Work in well-ventilated areas or under fume hoods to avoid inhalation. Prevent direct skin contact as the compound may cause sensitization. Use proper handling techniques to minimize dust generation and avoid ingestion. Follow GHS pictogram warnings (GHS07, GHS09) and maintain good laboratory hygiene practices.

Ethyl 5,5-diphenyl-4H-1,2-oxazole-3-carboxylate should be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from heat sources and direct sunlight. Keep containers upright and properly labeled with hazard information. Due to its aquatic toxicity classification (Aquatic Acute 1, Aquatic Chronic 1), ensure storage areas have appropriate containment measures to prevent environmental release. Store away from incompatible materials and maintain proper inventory records for regulatory compliance.

Immediate action is required upon contact with ethyl 5,5-diphenyl-4H-1,2-oxazole-3-carboxylate. For skin contact, immediately remove contaminated clothing and wash affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, rinse immediately with clean water for 15 minutes while holding eyelids open. If inhaled, move to fresh air immediately. If ingested, do not induce vomiting and seek medical attention. Always consult a physician if symptoms persist or worsen.

Ethyl 5,5-diphenyl-4H-1,2-oxazole-3-carboxylate must be disposed of as hazardous chemical waste through licensed waste management companies. Due to its aquatic toxicity classification, prevent release to sewers, waterways, or soil. Collect waste in properly labeled containers compatible with the chemical. Follow local and national regulations including REACH and CLP requirements. Incineration at authorized facilities is typically the preferred disposal method for organic compounds. Maintain disposal records for regulatory compliance and traceability.

Ethyl 5,5-diphenyl-4H-1,2-oxazole-3-carboxylate is classified as ADR Class 9 (Miscellaneous dangerous substances), Packing Group III for transportation. Use UN-approved packaging suitable for Class 9 materials with proper labeling and documentation. Ensure packages are properly sealed, labeled with correct shipping names, and accompanied by appropriate transport documents. Vehicles must comply with ADR regulations for Class 9 substances. Training of transport personnel and emergency response procedures are mandatory for safe transportation.

Ethyl 5,5-diphenyl-4H-1,2-oxazole-3-carboxylate is subject to European chemical regulations including REACH and CLP classifications. While not currently listed as a Substance of Very High Concern (SVHC), it must comply with standard registration and safety data sheet requirements. Its hazard classifications (Acute Tox. 4, Skin Sens. 1, Aquatic toxicity) mandate specific labeling with Warning signal word and GHS pictograms. Users must follow occupational exposure limits and environmental protection measures as specified in safety regulations.

Ethyl 5,5-diphenyl-4H-1,2-oxazole-3-carboxylate is available through OYSI, a specialized European distributor of technical chemicals and research compounds. OYSI provides reliable supply chains for laboratory and industrial customers across Europe, ensuring proper handling, storage, and documentation compliance. As a professional chemical distributor, OYSI offers technical support and regulatory guidance for safe use. Contact OYSI directly for availability, specifications, and pricing information tailored to your specific application requirements.