Diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate

Diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate is an organic chemical compound with CAS number 103976-28-9 and molecular formula C16H21NO5. This substance has a molecular weight of 307.34 g/mol and belongs to the class of malonate derivatives. It features an ethoxyanilino group linked to a propanedioate backbone, making it a specialized intermediate compound used in various chemical synthesis applications.

Diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate is a solid organic compound at room temperature with a molecular weight of 307.34 g/mol. The substance contains both hydrophilic and lipophilic structural elements due to its ethoxy and ester groups. Its malonate ester structure suggests moderate solubility in organic solvents. The compound's stability and exact physical appearance may vary depending on purity and storage conditions.

Diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate is primarily used as a chemical intermediate in pharmaceutical and fine chemical synthesis. Its malonate ester structure makes it valuable for various organic reactions, including condensation and cyclization processes. The compound may serve as a building block for developing pharmaceutical compounds, agrochemicals, or specialty chemicals requiring its specific structural features and reactivity patterns.

Diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate requires careful handling due to its Acute Toxicity 4 classification. Operators must wear appropriate personal protective equipment including safety glasses, gloves, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods. Avoid skin and eye contact, inhalation, and ingestion. Implement proper hygiene measures including thorough hand washing after handling.

Diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate should be stored in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Keep containers tightly closed and properly labeled with GHS07 and GHS09 pictograms. Store separately from incompatible materials and ensure adequate containment to prevent environmental release. Regular inspection of storage containers is recommended to maintain product integrity and safety standards.

Immediate action is required upon contact with diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate due to its toxicity classification. For skin contact, remove contaminated clothing and wash thoroughly with soap and water. In case of eye contact, rinse immediately with plenty of water for at least 15 minutes. If inhaled, move to fresh air. For ingestion, do not induce vomiting and seek immediate medical attention.

Diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate must be disposed of through authorized waste management companies specializing in chemical waste. The substance cannot be disposed of in regular waste streams due to its toxicity and environmental hazard classifications. Collect waste in appropriate containers, properly labeled according to local regulations. Disposal methods may include incineration at licensed facilities or other approved treatment methods following national and EU waste regulations.

Diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate is classified as ADR Class 9 (Miscellaneous Dangerous Substances), Packing Group III for transportation. Shipments must comply with dangerous goods regulations including proper packaging, labeling, and documentation. Use UN-approved packaging and ensure vehicles are properly placarded. Drivers must have appropriate dangerous goods training. Transport documentation must include proper shipping names and hazard classifications according to international transport regulations.

Diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate is subject to EU REACH and CLP regulations but is not classified as a Substance of Very High Concern (SVHC). The substance requires proper classification and labeling with Warning signal word and appropriate GHS pictograms (GHS07, GHS09). Companies must ensure compliance with registration requirements, safety data sheet provisions, and occupational exposure limits where applicable under European chemical legislation.

Diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate is available through OYSI, a specialized European distributor of chemical products. OYSI provides reliable supply chains for laboratory and industrial customers across Europe, ensuring proper handling, documentation, and regulatory compliance. As a professional chemical distributor, OYSI maintains quality standards and provides technical support for customers requiring this specialized chemical intermediate for their applications.