Diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate

Diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate is an organic chemical compound with the molecular formula C16H21NO5 and CAS number 103976-28-9. This substance has a molecular weight of 307.34 g/mol and belongs to the family of diethyl malonate derivatives. It features an ethoxyanilino group linked through a methylidene bridge to a propanedioate backbone. The compound is classified as moderately hazardous with acute toxicity category 4 and chronic aquatic toxicity category 2.

Diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate is an organic solid compound with a molecular weight of 307.34 g/mol and the molecular formula C16H21NO5. As a diethyl ester derivative containing aromatic and aliphatic components, it typically exhibits limited water solubility but good solubility in organic solvents. The compound's physical appearance, exact melting point, and specific solubility parameters would need to be determined through analytical testing for precise handling requirements.

Diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate is primarily used as an intermediate in organic synthesis and pharmaceutical research. Its malonate ester structure makes it valuable for various chemical transformations including condensation reactions, cyclizations, and as a building block for more complex molecules. The compound may also find applications in specialty chemical manufacturing, agrochemical synthesis, and as a research reagent in academic and industrial laboratories developing new organic compounds.

Diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate requires careful handling due to its Acute Tox. 4 classification. Wear appropriate personal protective equipment including safety glasses, chemical-resistant gloves, and protective clothing. Work in well-ventilated areas or under fume hoods to avoid inhalation exposure. Avoid skin and eye contact, and prevent ingestion. The Warning signal word indicates moderate hazard level, but proper safety protocols must always be followed during handling and processing operations.

Diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep containers closed when not in use and protect from light and moisture. Due to its organic ester nature, avoid storage near strong oxidizing agents, acids, or bases. Maintain storage temperatures according to supplier specifications and ensure proper labeling with GHS pictograms GHS07 and GHS09 for safety identification.

In case of skin contact with diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate, immediately remove contaminated clothing and wash affected area thoroughly with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for 15 minutes and seek medical attention. If inhaled, move to fresh air immediately. In case of ingestion, do not induce vomiting and seek immediate medical attention. Always consult the safety data sheet for complete first aid procedures and contact emergency services if necessary.

Diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate must be disposed of in accordance with local, national, and EU waste regulations due to its toxicity classification and environmental impact. The substance requires handling as hazardous waste and should not be discharged into sewers, soil, or waterways due to its Aquatic Chronic 2 classification. Contact licensed waste disposal companies for proper treatment and disposal. Small laboratory quantities may require incineration at authorized facilities under controlled conditions.

Diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate is classified under ADR Class 9 (Miscellaneous dangerous substances), Packing Group III for transportation purposes. This classification requires appropriate packaging, labeling, and documentation for road transport within Europe. Use UN-approved packaging suitable for Packing Group III substances and ensure proper shipping documentation includes the correct UN number and classification. Transport vehicles must comply with ADR requirements for Class 9 materials and carry appropriate emergency response information.

Diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate is subject to standard EU chemical regulations including REACH and CLP classifications but is not currently listed as a Substance of Very High Concern (SVHC). The substance must be handled according to its harmonized classification as Acute Tox. 4 and Aquatic Chronic 2, requiring appropriate risk management measures. Users must comply with occupational exposure limits, environmental discharge restrictions, and proper waste management protocols as defined by national and EU legislation.

Diethyl 2-[(4-ethoxyanilino)methylidene]propanedioate is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides this compound to industrial customers, research institutions, and chemical manufacturers across Europe with proper regulatory compliance and technical support. As a professional chemical distributor, OYSI ensures appropriate packaging, documentation, and safety data sheets for safe handling and regulatory compliance. Contact OYSI directly for availability, specifications, and technical assistance for your specific application requirements.