5-bromo-1,2,3-trifluorobenzene

5-bromo-1,2,3-trifluorobenzene is a halogenated aromatic compound with the molecular formula C6H2BrF3 and CAS number 138526-69-9. This chemical features a benzene ring substituted with one bromine atom and three fluorine atoms in specific positions. With a molecular weight of 210.98 g/mol, it belongs to the class of organofluorine compounds commonly used as intermediates in pharmaceutical and agrochemical synthesis.

5-bromo-1,2,3-trifluorobenzene is typically a clear to pale yellow liquid at room temperature with a characteristic aromatic odor. The compound has a molecular weight of 210.98 g/mol and contains both bromine and fluorine substituents that significantly influence its chemical behavior. Due to its halogenated structure, it exhibits limited water solubility but good solubility in organic solvents such as alcohols, ethers, and aromatic hydrocarbons.

5-bromo-1,2,3-trifluorobenzene serves primarily as an intermediate in organic synthesis, particularly in pharmaceutical and agrochemical industries. The compound is valuable for preparing complex fluorinated molecules through various coupling reactions, including Suzuki-Miyaura and Stille reactions. Its unique substitution pattern makes it useful for synthesizing biologically active compounds where specific fluorine positioning is crucial for desired pharmacological or pesticidal properties.

5-bromo-1,2,3-trifluorobenzene requires careful handling due to its classification as flammable liquid category 3, skin irritant category 2, and suspected carcinogen category 2. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods, avoid direct skin contact, and keep away from heat sources and ignition. Emergency eyewash stations and safety showers should be readily accessible.

5-bromo-1,2,3-trifluorobenzene should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and ignition. Keep containers upright and protected from direct sunlight and temperature fluctuations. Store separately from strong oxidizing agents, strong bases, and incompatible materials. Ensure storage areas have appropriate fire suppression systems and that containers are properly labeled according to GHS requirements including danger signal word and appropriate pictograms.

Immediate action is required upon contact with 5-bromo-1,2,3-trifluorobenzene due to its irritant and potentially carcinogenic properties. For skin contact, immediately remove contaminated clothing and wash affected area with soap and water for at least 15 minutes. In case of eye contact, flush immediately with water for 15 minutes and seek medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention.

5-bromo-1,2,3-trifluorobenzene waste must be disposed of according to local, national, and EU regulations as hazardous waste. The compound cannot be disposed of in regular waste streams due to its flammable, potentially carcinogenic, and environmentally hazardous properties. Contact licensed hazardous waste disposal companies for proper treatment, which typically involves high-temperature incineration in specialized facilities. Maintain detailed waste disposal records and ensure proper waste classification and labeling throughout the disposal process.

5-bromo-1,2,3-trifluorobenzene is classified under ADR Class 3 (flammable liquids), Packing Group III for transportation purposes. Packaging must comply with UN specifications and be properly labeled with appropriate hazard markings and transport documentation. Vehicles must carry appropriate emergency equipment and placards. Drivers require ADR training certification for dangerous goods transport. Shipments must include safety data sheets and emergency response information, and transport should avoid extreme temperatures and rough handling.

5-bromo-1,2,3-trifluorobenzene is subject to standard EU chemical regulations including REACH registration requirements and CLP classification obligations. While not currently listed as a Substance of Very High Concern (SVHC), its Carcinogen Category 2 classification requires specific risk management measures and safety data sheet provisions. Users must comply with occupational exposure limits, waste disposal regulations, and transport requirements under ADR. Regular monitoring of regulatory updates is recommended as classification may evolve.

5-bromo-1,2,3-trifluorobenzene is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides this compound with full regulatory compliance including proper CLP labeling, safety data sheets, and REACH documentation. As a professional chemical distributor, OYSI ensures product quality, proper packaging, and reliable supply chain management across European markets. Contact OYSI directly for current availability, specifications, and technical support for your specific application requirements.