5-bromo-1,2,3-trifluorobenzene

5-bromo-1,2,3-trifluorobenzene is an aromatic halogenated compound with the molecular formula C6H2BrF3 and CAS number 138526-69-9. This chemical features a benzene ring substituted with one bromine atom and three fluorine atoms in specific positions. With a molecular weight of 210.98 g/mol, it belongs to the class of polyhaloaromatic compounds and serves as an important intermediate in organic synthesis and pharmaceutical chemistry.

5-bromo-1,2,3-trifluorobenzene is a liquid at room temperature with flammable properties classified as Flam. Liq. 3. The compound exhibits typical aromatic characteristics with enhanced chemical stability due to fluorine substitution. Its high degree of halogenation affects its solubility profile, making it more compatible with organic solvents than water. The presence of both bromine and fluorine atoms significantly influences its reactivity and physical properties.

5-bromo-1,2,3-trifluorobenzene is primarily used as a key intermediate in pharmaceutical synthesis and fine chemical manufacturing. The compound serves in the production of advanced materials, agrochemicals, and specialty chemicals where specific halogenation patterns are required. Its unique substitution pattern makes it valuable for cross-coupling reactions and nucleophilic aromatic substitutions in medicinal chemistry and materials science applications.

5-bromo-1,2,3-trifluorobenzene requires careful handling due to its classification as Carc. 2, Skin Irrit. 2, and Eye Dam. 1. Essential protective equipment includes chemical-resistant gloves, safety goggles or face shield, and protective clothing. Work in well-ventilated areas or under fume hoods to prevent inhalation. Avoid skin and eye contact, sources of ignition, and ensure proper grounding due to its flammable nature.

5-bromo-1,2,3-trifluorobenzene must be stored in a cool, dry, well-ventilated area away from heat sources, sparks, and open flames due to its flammable classification. Use appropriate chemical-resistant containers with tight-fitting lids to prevent vapor release. Store separately from strong oxidizing agents, bases, and incompatible materials. Maintain temperature control and ensure proper labeling with hazard identification according to GHS requirements.

Immediate action is required upon contact with 5-bromo-1,2,3-trifluorobenzene due to its eye damage and skin irritation potential. For eye contact, rinse immediately with plenty of water for at least 15 minutes and seek medical attention. For skin contact, wash thoroughly with soap and water. If inhaled, move to fresh air immediately. Remove contaminated clothing and seek medical advice, particularly due to the carcinogenic classification.

5-bromo-1,2,3-trifluorobenzene disposal must comply with local and national hazardous waste regulations due to its multiple hazard classifications. The compound requires treatment as hazardous waste and cannot be disposed of in regular trash or sewers. Contact licensed waste disposal companies for proper handling and destruction, typically through high-temperature incineration at authorized facilities. Maintain disposal documentation for regulatory compliance.

5-bromo-1,2,3-trifluorobenzene is classified as ADR Class 3, Packing Group III for transportation purposes. The compound must be packaged in UN-approved containers with appropriate hazard labels including flammable liquid markings. Transport documentation must include proper shipping names, hazard classifications, and emergency response information. Vehicles must comply with ADR requirements for flammable liquids transport and carry appropriate emergency equipment.

5-bromo-1,2,3-trifluorobenzene is subject to REACH registration requirements in Europe and CLP classification regulations. The compound is not currently listed as an SVHC (Substance of Very High Concern), but its Carc. 2 classification requires compliance with carcinogen handling regulations. Users must maintain safety data sheets, implement appropriate risk management measures, and ensure worker protection according to occupational health and safety directives.

5-bromo-1,2,3-trifluorobenzene is available through OYSI, a specialized European distributor of fine chemicals and pharmaceutical intermediates. OYSI provides this compound with full regulatory compliance including REACH registration and proper safety documentation. As a professional chemical supplier, OYSI ensures quality standards, appropriate packaging, and regulatory support for industrial and research applications throughout Europe.