4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione
C15H23NO4
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Identification
- CAS Number
- 66-81-9
- EC Number
- 200-636-0
- UN Number
- 2588
- Index Number
- 613-140-00-8
- PubChem CID
- 6197
Physical-chemical properties
- Molecular Formula
- C15H23NO4
- Molar Mass
- 281.35 g/mol
- IUPAC Name
- 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione
Chemical Identifiers
- InChI
- InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
- InChI Key
- YPHMISFOHDHNIV-FSZOTQKASA-N
Overview
4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione (CAS 66-81-9) is a complex organic compound featuring both cyclohexyl and piperidine structural motifs with significant biological activity. This pharmaceutical intermediate represents a sophisticated molecular structure characterized by its stereochemically defined configuration and multiple functional groups. With the molecular formula C15H23NO4 and a molecular weight of 281.35 g/mol, this compound exhibits considerable structural complexity that distinguishes it from simpler organic molecules such as N-methylaniline. The presence of both hydroxyl and carbonyl functionalities, combined with the bicyclic framework, contributes to its distinctive chemical behavior and biological properties. The compound's safety profile requires careful consideration due to its classification under multiple hazard categories. It presents mutagenic properties (Muta. 2), reproductive toxicity (Repr. 1B), and acute toxicity (Acute Tox. 2), necessitating specialized handling procedures and appropriate personal protective equipment. The substance also demonstrates aquatic chronic toxicity (Aquatic Chronic 2), requiring environmental precautions during storage and disposal. Transportation falls under ADR Class 6.1, reflecting its toxic nature. Primary industrial applications include pharmaceutical synthesis as an advanced intermediate, where its specific stereochemistry proves crucial for developing therapeutic compounds. The compound also finds use in specialized chemical research applications and as a building block for complex molecular architectures. Its unique structural features make it valuable in medicinal chemistry programs targeting specific biological pathways. OYSI maintains reliable supply chains for this specialized pharmaceutical intermediate, ensuring consistent availability for European industrial customers requiring high-purity chemical compounds.
Safety & Classification
Muta. 2; Repr. 1B; Acute Tox. 2 *; Aquatic Chronic 2
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 2588 |
| ADR Class | 6.1 |
| Packing Group | I |
| Tunnel Code | C/E |
| Proper Shipping Name | Cycloheximid, fest, sehr giftig |
| Marine Pollutant | No |
Frequently Asked Questions
What is 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione?
4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione is a complex organic compound with the molecular formula C15H23NO4 and molecular weight of 281.35 g/mol. This substance, identified by CAS number 66-81-9, is classified as a highly hazardous chemical with mutagenic and reproductive toxicity properties. It requires strict handling protocols due to its acute toxicity and environmental impact concerns.
What are the physicochemical properties of 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione?
4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione is an organic compound with a molecular weight of 281.35 g/mol and formula C15H23NO4. The substance contains multiple functional groups including piperidine rings and cyclohexyl moieties. Its complex stereochemistry is defined by specific R and S configurations at various positions, indicating precise three-dimensional molecular structure that influences its biological and chemical properties.
What is 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione used for?
4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione is used in specialized chemical research and pharmaceutical applications. Due to its complex molecular structure and biological activity, it serves as an intermediate in synthetic chemistry and pharmaceutical development. However, its use is strictly regulated due to its mutagenic and reproductive toxicity properties, requiring appropriate licensing and safety measures for professional applications.
How to handle 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione safely?
4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione requires maximum safety precautions due to its Acute Tox. 2, Muta. 2, and Repr. 1B classifications. Essential PPE includes chemical-resistant gloves, protective clothing, eye protection, and respiratory equipment. Work must be conducted in well-ventilated areas or fume hoods. Avoid skin contact, inhalation, and ingestion. Only trained personnel should handle this substance following strict safety protocols.
How to store 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione correctly?
4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione must be stored in secure, controlled conditions due to its high toxicity classification. Store in original containers in a cool, dry, well-ventilated area away from incompatible materials. Access should be restricted to authorized personnel only. Ensure proper labeling with GHS pictograms (GHS06, GHS08, GHS09) and implement appropriate containment measures to prevent environmental release.
What to do in case of contact with 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione?
Immediate action is critical following contact with 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione due to its acute toxicity. For skin contact: remove contaminated clothing and flush with water for 15 minutes. For eye contact: rinse immediately with water for 15 minutes. If inhaled: move to fresh air immediately. If ingested: do not induce vomiting. Seek immediate medical attention in all cases and provide safety data sheet to medical personnel.
How to dispose of 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione appropriately?
4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione requires specialized hazardous waste disposal due to its toxic and environmental properties. Disposal must comply with local and national regulations for hazardous substances. Contact licensed hazardous waste disposal companies for proper treatment. Never dispose of in regular waste streams or sewage systems due to its Aquatic Chronic 2 classification and high toxicity profile.
How to transport 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione?
4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione is classified under ADR Class 6.1 (Toxic substances), Packing Group I, indicating maximum danger level. Transportation requires UN-approved packaging, proper labeling with toxic substance markings, and transport documents. Only certified carriers experienced in dangerous goods transport should handle shipments. Emergency response information must accompany the shipment, and specific routing restrictions may apply.
Is 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione subject to specific regulations?
4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione is subject to strict European regulations under REACH and CLP due to its hazardous properties. While not currently listed as SVHC, its Muta. 2 and Repr. 1B classifications require compliance with reproductive toxicity regulations. Users must ensure proper registration, safety data sheets, and exposure scenarios. Additional national restrictions may apply for procurement, use, and disposal of this highly toxic substance.
Where to buy 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione in Europe?
4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione is available through OYSI, a specialized European distributor of technical chemicals. Due to its high toxicity classification and regulatory requirements, purchase requires appropriate licensing and qualification verification. OYSI ensures compliance with European regulations and provides necessary documentation including safety data sheets and certificates of analysis. Contact OYSI directly for availability, specifications, and regulatory compliance support for this controlled substance.
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4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione is a dangerous good. We support you with labeling, packaging, and transport documentation.
Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.