2,3-dichloroquinoxaline-6-carbonyl chloride

2,3-dichloroquinoxaline-6-carbonyl chloride is an organic chemical compound with the molecular formula C9H3Cl3N2O and CAS number 1919-43-3. This compound belongs to the quinoxaline family and features both dichloro substitutions on the quinoxaline ring and an acyl chloride functional group. With a molecular weight of 261.5 g/mol, it serves as an important intermediate in organic synthesis and pharmaceutical chemistry applications.

2,3-dichloroquinoxaline-6-carbonyl chloride is a crystalline solid at room temperature with a molecular weight of 261.5 g/mol. As an acyl chloride derivative, it is moisture-sensitive and reactive toward nucleophiles. The compound typically appears as a pale yellow to off-white solid and is soluble in organic solvents such as dichloromethane, chloroform, and THF, but reacts with water and alcohols.

2,3-dichloroquinoxaline-6-carbonyl chloride is primarily used as a synthetic intermediate in pharmaceutical and agrochemical manufacturing. Its acyl chloride functionality makes it valuable for coupling reactions to form amides, esters, and other derivatives. The compound serves as a building block in the synthesis of bioactive molecules, including potential pharmaceutical compounds and research chemicals in medicinal chemistry applications.

2,3-dichloroquinoxaline-6-carbonyl chloride should be handled in a well-ventilated area or fume hood using appropriate personal protective equipment. Wear chemical-resistant gloves, safety goggles, and protective clothing to prevent skin and eye contact. As an acyl chloride, it can be corrosive and moisture-sensitive, so work in dry conditions and avoid contact with water or alcohols. Use proper laboratory techniques and ensure adequate ventilation.

2,3-dichloroquinoxaline-6-carbonyl chloride must be stored in a cool, dry place away from moisture and humidity. Keep the container tightly sealed in an inert atmosphere if possible, as acyl chlorides are sensitive to hydrolysis. Store away from alcohols, amines, and other nucleophiles that could react with the compound. Use appropriate secondary containment and ensure storage areas are well-ventilated and temperature-controlled.

In case of skin contact with 2,3-dichloroquinoxaline-6-carbonyl chloride, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for at least 15 minutes and seek medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention.

2,3-dichloroquinoxaline-6-carbonyl chloride must be disposed of according to local and national waste regulations as hazardous chemical waste. Do not dispose of in regular trash or pour down drains. Contact licensed waste disposal companies for proper handling and treatment. The compound should be collected in appropriate containers, labeled clearly, and treated through approved incineration or chemical neutralization methods under professional supervision.

2,3-dichloroquinoxaline-6-carbonyl chloride is classified under ADR Class 8 (Corrosive substances), Packing Group II. Transport requires appropriate hazardous material packaging, labeling, and documentation according to dangerous goods regulations. Use UN-approved containers and ensure proper marking with the correct UN number and hazard labels. Shipping must comply with ADR/RID regulations for road and rail transport within Europe.

2,3-dichloroquinoxaline-6-carbonyl chloride is subject to standard chemical regulations including REACH registration requirements for commercial use in the European Union. While not classified as a SVHC (Substance of Very High Concern), it must comply with CLP regulation for classification, labeling, and packaging. Users should maintain safety data sheets and follow workplace exposure guidelines and local chemical handling regulations.

2,3-dichloroquinoxaline-6-carbonyl chloride is available through OYSI, a specialized European distributor of fine chemicals and pharmaceutical intermediates. OYSI provides reliable sourcing and distribution across Europe with proper regulatory compliance and technical support. Contact OYSI directly for availability, specifications, and delivery options to meet your specific research or manufacturing requirements with appropriate documentation and quality assurance.