2-hydroxy-2-methylpropanenitrile
C4H7NO
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Identification
- CAS Number
- 75-86-5
- EC Number
- 200-909-4
- UN Number
- 1541
- Index Number
- 608-004-00-X
- PubChem CID
- 6406
Physical-chemical properties
- Molecular Formula
- C4H7NO
- Molar Mass
- 85.10 g/mol
- IUPAC Name
- 2-hydroxy-2-methylpropanenitrile
Chemical Identifiers
- InChI
- InChI=1S/C4H7NO/c1-4(2,6)3-5/h6H,1-2H3
- InChI Key
- MWFMGBPGAXYFAR-UHFFFAOYSA-N
Overview
2-hydroxy-2-methylpropanenitrile (CAS 75-86-5) is a highly toxic organic nitrile compound with significant industrial applications and severe safety considerations. This chemical substance, also known by its IUPAC designation 2-hydroxy-2-methylpropanenitrile, represents a specialized nitrile derivative characterized by both hydroxyl and cyano functional groups within its molecular structure. With a molecular formula of C4H7NO and molecular weight of 85.1 g/mol, this compound exhibits unique chemical properties that make it valuable in specific industrial processes while requiring extreme caution in handling and storage. The substance carries critical safety classifications under the Globally Harmonized System, including Acute Toxicity Category 1 and 2 designations, reflecting its extremely hazardous nature to human health. The "Danger" signal word and associated GHS06 (skull and crossbones) and GHS09 (environmental hazard) pictograms emphasize the severe risks associated with exposure. Transportation regulations classify it under ADR Class 6.1, indicating its status as a toxic substance requiring specialized handling protocols. Safety considerations are paramount when working with 2-hydroxy-2-methylpropanenitrile, as it poses significant acute toxicity risks through multiple exposure routes and presents both aquatic acute and chronic environmental hazards. Like other toxic compounds such as zinc dicyanide, proper containment and emergency procedures are essential for safe industrial use. Primary industrial applications include specialized chemical synthesis processes, pharmaceutical intermediate production, and research applications where its unique nitrile-hydroxyl combination provides specific reactivity profiles. The compound serves as a building block in organic synthesis pathways requiring precise functional group manipulation. OYSI maintains availability of 2-hydroxy-2-methylpropanenitrile for qualified industrial customers with appropriate safety infrastructure and regulatory compliance capabilities.
Safety & Classification
Acute Tox. 2 *; Acute Tox. 1; Acute Tox. 2 *; Aquatic Acute 1; Aquatic Chronic 1
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Inhalation
Measures if vapours or dust are inhaled
First Aid Actions
- +P304IF INHALED:
- +P340Remove person to fresh air and keep comfortable for breathing.
- +P311Call a POISON CENTER/doctor.
Related hazard statements:
Skin Contact
Measures if substance contacts the skin
First Aid Actions
- +P302IF ON SKIN:
- +P352Wash with plenty of water.
- +P361Take off immediately all contaminated clothing.
- +P313Get medical advice/attention.
Related hazard statements:
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 1541 |
| ADR Class | 6.1 |
| Packing Group | I |
| Tunnel Code | C/D |
| Proper Shipping Name | Acetoncyanhydrin, stabilisiert |
| Marine Pollutant | No |
Frequently Asked Questions
What is 2-hydroxy-2-methylpropanenitrile?
2-hydroxy-2-methylpropanenitrile is an organic chemical compound with the molecular formula C4H7NO and CAS number 75-86-5. This nitrile compound has a molecular weight of 85.1 g/mol and contains both hydroxyl and nitrile functional groups. It is classified as a highly toxic substance with acute toxicity properties and poses significant environmental hazards to aquatic life. The compound requires careful handling due to its dangerous classification profile.
What are the physicochemical properties of 2-hydroxy-2-methylpropanenitrile?
2-hydroxy-2-methylpropanenitrile is a liquid organic compound at room temperature with the molecular formula C4H7NO. The compound has a molecular weight of 85.1 g/mol and contains both a hydroxyl group and a nitrile group in its structure. Due to the presence of the hydroxyl group, it likely exhibits some degree of water solubility. Its specific physical properties such as boiling point and density depend on the intermolecular interactions between its functional groups.
What is 2-hydroxy-2-methylpropanenitrile used for?
2-hydroxy-2-methylpropanenitrile is primarily used as a chemical intermediate in organic synthesis and pharmaceutical manufacturing. Its dual functional groups (hydroxyl and nitrile) make it valuable for creating more complex molecular structures through various chemical reactions. The compound serves as a building block in the production of specialty chemicals and may be utilized in research applications. Due to its high toxicity classification, its use is restricted to professional industrial applications with appropriate safety measures.
How to handle 2-hydroxy-2-methylpropanenitrile safely?
2-hydroxy-2-methylpropanenitrile requires extreme caution during handling due to its Acute Toxicity Class 1 and 2 classifications. Personnel must wear complete personal protective equipment including chemical-resistant gloves, safety goggles, and respiratory protection. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. The GHS06 pictogram indicates fatal toxicity risks, requiring strict adherence to safety protocols and emergency procedures availability at all times.
How to store 2-hydroxy-2-methylpropanenitrile correctly?
2-hydroxy-2-methylpropanenitrile must be stored in a secure, temperature-controlled environment away from incompatible materials. The storage area should be well-ventilated and equipped with appropriate containment measures for highly toxic substances. Containers must be properly labeled with GHS06 and GHS09 pictograms and kept tightly sealed to prevent vapor release. Access should be restricted to trained personnel only, and the storage location must comply with regulations for ADR Class 6.1 Packing Group I materials.
What to do in case of contact with 2-hydroxy-2-methylpropanenitrile?
Immediate action is critical due to the compound's high acute toxicity classification. In case of skin contact, remove contaminated clothing immediately and rinse the affected area with plenty of water for at least 15 minutes. For eye contact, flush thoroughly with water and seek immediate medical attention. If inhaled, move the person to fresh air immediately and provide oxygen if breathing is difficult. Contact emergency medical services promptly and provide the safety data sheet to medical personnel.
How to dispose of 2-hydroxy-2-methylpropanenitrile appropriately?
2-hydroxy-2-methylpropanenitrile must be disposed of as hazardous waste through licensed waste management companies due to its high toxicity and environmental hazard classifications. The compound cannot be disposed of in regular waste streams or sewage systems due to its Aquatic Acute 1 and Aquatic Chronic 1 classifications. Disposal must comply with local and European waste regulations for toxic substances. All containers and contaminated materials require professional hazardous waste treatment to prevent environmental contamination.
How to transport 2-hydroxy-2-methylpropanenitrile?
2-hydroxy-2-methylpropanenitrile is classified under ADR Class 6.1, Packing Group I, indicating it is a highly toxic substance requiring stringent transport regulations. Transportation must be conducted by certified dangerous goods carriers using appropriate packaging and labeling requirements. Vehicles must display proper placards and carry emergency response information. The compound requires specialized packaging that meets UN specifications for Packing Group I toxic substances, ensuring maximum protection during transit.
Is 2-hydroxy-2-methylpropanenitrile subject to specific regulations?
2-hydroxy-2-methylpropanenitrile is subject to comprehensive European chemical regulations including REACH registration requirements and CLP classification obligations. The compound is not currently listed as a Substance of Very High Concern (SVHC), but its high acute toxicity classification subjects it to strict handling and use restrictions. Companies must comply with occupational exposure limits, environmental discharge restrictions, and maintain safety data sheets. Professional users must implement risk management measures as specified in chemical safety assessments.
Where to buy 2-hydroxy-2-methylpropanenitrile in Europe?
2-hydroxy-2-methylpropanenitrile is available through OYSI, a specialized European distributor of technical chemicals with expertise in hazardous substances. As a professional chemical distributor, OYSI provides compliant packaging, proper documentation, and regulatory support for this highly toxic compound. Due to the substance's dangerous classification, purchases are restricted to qualified industrial users with appropriate handling capabilities. OYSI ensures all shipments meet ADR Class 6.1 Packing Group I transport requirements and regulatory compliance standards.
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Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.