2-chloro-N,N,6-trimethylpyrimidin-4-amine

2-chloro-N,N,6-trimethylpyrimidin-4-amine is a chlorinated pyrimidine derivative with the molecular formula C7H10ClN3 and CAS number 535-89-7. This organic compound has a molecular weight of 171.63 g/mol and belongs to the class of substituted aminopyrimidines. It features a pyrimidine ring substituted with chlorine at position 2, dimethylamino group at position 4, and a methyl group at position 6. The compound is classified as highly toxic with Acute Tox. 2 classification.

2-chloro-N,N,6-trimethylpyrimidin-4-amine is a crystalline solid at room temperature with a molecular weight of 171.63 g/mol. The compound contains both polar (amino and chloro substituents) and non-polar (methyl groups) regions, affecting its solubility profile. As a substituted pyrimidine, it typically exhibits limited water solubility but better solubility in organic solvents. The presence of the chlorine atom and tertiary amine functionality influences its chemical reactivity and stability under various conditions.

2-chloro-N,N,6-trimethylpyrimidin-4-amine serves as an important intermediate in pharmaceutical and agrochemical synthesis. This compound is primarily used in the manufacture of various bioactive molecules, including potential pharmaceutical compounds and pesticide formulations. Its substituted pyrimidine structure makes it valuable for creating derivatives with enhanced biological activity. The compound may also find applications in research and development of new therapeutic agents, particularly in areas where pyrimidine-based structures show promising biological properties.

2-chloro-N,N,6-trimethylpyrimidin-4-amine requires careful handling due to its Acute Tox. 2 classification and GHS06 pictogram indicating high toxicity. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and respiratory protection when handling powders. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid skin and eye contact completely. Use appropriate tools to minimize direct handling and ensure all personnel are trained in emergency procedures before working with this highly toxic substance.

2-chloro-N,N,6-trimethylpyrimidin-4-amine must be stored in a secure, well-ventilated area away from heat sources and incompatible materials. Keep containers tightly sealed and in original packaging to prevent contamination and exposure. Storage areas should be restricted to authorized personnel only due to the compound's high toxicity (Acute Tox. 2). Maintain stable temperature conditions and protect from moisture. Implement appropriate inventory controls and ensure storage complies with local regulations for highly toxic substances. Regular inspection of containers for damage is essential.

Immediate action is critical due to the compound's Acute Tox. 2 classification. For skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15-20 minutes. If inhaled, move to fresh air immediately and monitor breathing. For ingestion, do not induce vomiting and seek immediate medical attention. Always contact emergency medical services promptly and provide them with the safety data sheet for proper treatment guidance.

2-chloro-N,N,6-trimethylpyrimidin-4-amine must be disposed of as hazardous waste according to local and national regulations. This highly toxic substance cannot be disposed of through normal waste streams and requires specialized treatment by licensed waste management companies. Collect waste in appropriate containers, clearly labeled with contents and hazard information. Maintain detailed disposal records and ensure compliance with waste tracking requirements. Small laboratory quantities may require different disposal protocols than bulk industrial waste, so consult local environmental authorities for specific guidance.

2-chloro-N,N,6-trimethylpyrimidin-4-amine is classified as ADR Class 6.1 (toxic substances) Packing Group I, indicating high danger level for transport. Transportation requires UN-specification packaging appropriate for toxic solids and proper hazard labeling with Class 6.1 labels. Shipping documents must include proper shipping names, UN numbers, and emergency response information. Only certified carriers experienced in handling toxic materials should transport this substance. Ensure compliance with international transport regulations (ADR/RID for road/rail, IMDG for sea, IATA for air transport).

2-chloro-N,N,6-trimethylpyrimidin-4-amine is subject to comprehensive chemical safety regulations including REACH registration requirements in Europe and CLP classification as Acute Tox. 2 with Danger signal word. The compound is not currently listed as a Substance of Very High Concern (SVHC). Manufacturers and importers must comply with safety data sheet requirements and workplace exposure limits. Additional restrictions may apply depending on intended use, particularly for pharmaceutical or pesticide applications. Companies must ensure proper risk assessment and implementation of adequate control measures.

2-chloro-N,N,6-trimethylpyrimidin-4-amine is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides this compound to qualified industrial customers with appropriate handling capabilities and regulatory compliance. Due to the substance's high toxicity classification (Acute Tox. 2), purchases are restricted to professional users with proper safety infrastructure. Contact OYSI directly for availability, technical specifications, and regulatory documentation required for your specific application and jurisdiction.