2-[2-(4-chlorophenyl)-2-phenylacetyl]indene-1,3-dione

2-[2-(4-chlorophenyl)-2-phenylacetyl]indene-1,3-dione is a synthetic organic compound with the molecular formula C23H15ClO3 and CAS number 3691-35-8. This chemical features an indene-1,3-dione core structure substituted with a complex aromatic acetyl group containing both chlorophenyl and phenyl moieties. With a molecular weight of 374.8 g/mol, it is classified as an extremely hazardous substance requiring specialized handling protocols due to its high toxicity profile.

2-[2-(4-chlorophenyl)-2-phenylacetyl]indene-1,3-dione is a solid organic compound at room temperature with a molecular weight of 374.8 g/mol. The presence of the chlorine atom and multiple aromatic rings suggests limited water solubility but good solubility in organic solvents. The compound's extensive conjugated system likely imparts a colored appearance, though specific physical properties such as melting point, boiling point, and exact solubility data require experimental determination for precise characterization.

2-[2-(4-chlorophenyl)-2-phenylacetyl]indene-1,3-dione is primarily used as a research chemical and intermediate in pharmaceutical synthesis. The indene-1,3-dione scaffold is valuable in medicinal chemistry for developing bioactive compounds. Given its high toxicity classification, this substance is restricted to specialized applications in controlled laboratory environments, pharmaceutical research, and potentially as a synthetic intermediate where its unique structural features are required for specific chemical transformations.

2-[2-(4-chlorophenyl)-2-phenylacetyl]indene-1,3-dione requires extreme safety precautions due to its Acute Tox. 1 classification. Full personal protective equipment including chemical-resistant gloves, safety goggles, and respiratory protection is mandatory. Work must be conducted in a well-ventilated fume hood or controlled atmosphere. Avoid all contact with skin, eyes, and respiratory system. Only trained personnel should handle this substance, and emergency procedures must be readily available given its extremely hazardous nature.

2-[2-(4-chlorophenyl)-2-phenylacetyl]indene-1,3-dione must be stored in a secure, temperature-controlled environment away from incompatible materials. Keep containers tightly sealed in a cool, dry place with adequate ventilation. Due to its extreme toxicity and environmental hazard classification, storage requires specialized containment systems with secondary containment measures. Access should be restricted to authorized personnel only, and inventory must be carefully tracked according to local regulations for highly toxic substances.

Immediate action is critical due to the substance's Acute Tox. 1 classification. For skin contact, remove contaminated clothing and flush with copious amounts of water for at least 15 minutes. If inhaled, move to fresh air immediately and seek medical attention. For eye contact, rinse thoroughly with water. In all cases of exposure, seek immediate medical attention and provide the safety data sheet to medical personnel. Do not induce vomiting if ingested, and contact poison control centers immediately.

2-[2-(4-chlorophenyl)-2-phenylacetyl]indene-1,3-dione requires specialized hazardous waste disposal due to its extreme toxicity and environmental hazard classifications. Disposal must be conducted through licensed hazardous waste disposal companies following local and EU regulations. The substance cannot be discharged to sewers or the environment due to its Aquatic Acute 1 and Aquatic Chronic 1 classifications. Incineration at authorized high-temperature facilities may be required, with proper emission controls to prevent environmental contamination.

2-[2-(4-chlorophenyl)-2-phenylacetyl]indene-1,3-dione is classified as ADR Class 6.1 (Toxic substances), Packing Group I, indicating maximum danger level for toxic materials. Transportation requires specialized packaging meeting UN specifications, proper labeling with GHS pictogrammes (GHS06, GHS08, GHS09), and documentation including transport emergency cards. Only certified carriers experienced in handling extremely toxic materials should transport this substance, following strict ADR regulations for the most hazardous category of toxic substances.

2-[2-(4-chlorophenyl)-2-phenylacetyl]indene-1,3-dione is subject to comprehensive EU chemical regulations including REACH registration requirements and CLP classification standards. Its multiple hazard classifications (Repr. 1B, Acute Tox. 1, STOT RE 1, Aquatic hazards) trigger strict regulatory controls. While not currently listed as an SVHC, its extreme toxicity profile means it may face restrictions on use, require authorization for certain applications, and must comply with occupational exposure limits and environmental protection measures.

2-[2-(4-chlorophenyl)-2-phenylacetyl]indene-1,3-dione is available through OYSI, a specialized European distributor of technical chemicals. As an extremely hazardous substance with Acute Tox. 1 classification, purchase requires proper documentation including end-use declarations and qualified personnel certifications. OYSI provides comprehensive regulatory support and ensures compliance with EU chemical regulations. Due to the substance's hazardous nature, availability may be restricted to qualified research institutions and licensed pharmaceutical companies with appropriate handling facilities.