1,4,7,10-tetrakis-(4-methylphenyl)sulfonyl-1,4,7,10-tetrazacyclododecane

1,4,7,10-tetrakis-(4-methylphenyl)sulfonyl-1,4,7,10-tetrazacyclododecane is an organosulfur compound with the molecular formula C36H44N4O8S4 and CAS number 52667-88-6. This tetrazacyclododecane derivative features four tosyl groups attached to the nitrogen atoms of the macrocyclic ring. With a molecular weight of 789 g/mol, it belongs to the family of sulfonamide-protected cyclen compounds commonly used in coordination chemistry and pharmaceutical applications.

1,4,7,10-tetrakis-(4-methylphenyl)sulfonyl-1,4,7,10-tetrazacyclododecane is a solid crystalline compound at room temperature with a molecular weight of 789 g/mol. As a highly substituted organic molecule containing multiple aromatic rings and sulfonyl groups, it typically exhibits limited water solubility but good solubility in organic solvents such as DMF, DMSO, and chlorinated solvents. The compound appears as a white to off-white powder under normal storage conditions.

1,4,7,10-tetrakis-(4-methylphenyl)sulfonyl-1,4,7,10-tetrazacyclododecane serves primarily as a protected intermediate in the synthesis of cyclen-based chelating agents and macrocyclic ligands. It finds applications in pharmaceutical research, particularly in developing contrast agents for medical imaging, radiopharmaceuticals, and metal ion chelation therapy. The compound is also used in coordination chemistry research and as a building block for advanced materials requiring selective metal binding properties.

1,4,7,10-tetrakis-(4-methylphenyl)sulfonyl-1,4,7,10-tetrazacyclododecane requires careful handling due to its skin sensitization potential (Skin Sens. 1). Always wear appropriate personal protective equipment including nitrile gloves, safety glasses, and laboratory coats. Work in well-ventilated areas or under fume hoods to minimize exposure. Avoid direct skin contact and inhalation. Use proper handling techniques to prevent dust formation and ensure all personnel are trained on the safety data sheet requirements before use.

1,4,7,10-tetrakis-(4-methylphenyl)sulfonyl-1,4,7,10-tetrazacyclododecane should be stored in a cool, dry place away from direct sunlight and moisture. Keep containers tightly sealed in their original packaging to prevent contamination and degradation. Store separately from incompatible materials such as strong oxidizing agents and bases. Maintain storage areas with adequate ventilation and temperature control. Regularly inspect containers for signs of deterioration and ensure proper labeling according to GHS requirements.

Skin contact with 1,4,7,10-tetrakis-(4-methylphenyl)sulfonyl-1,4,7,10-tetrazacyclododecane requires immediate action due to its sensitization potential. Remove contaminated clothing and wash affected skin thoroughly with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for 15 minutes. If inhaled, move to fresh air immediately. Seek medical attention if irritation persists or allergic reactions develop. Do not induce vomiting if accidentally ingested and contact poison control immediately.

1,4,7,10-tetrakis-(4-methylphenyl)sulfonyl-1,4,7,10-tetrazacyclododecane must be disposed of according to local and national hazardous waste regulations due to its environmental hazard classification (Aquatic Acute 1, Aquatic Chronic 1). Contact licensed hazardous waste disposal companies for proper treatment and disposal. Do not discharge to sewers, waterways, or soil. Contaminated packaging should also be treated as hazardous waste. Maintain proper documentation of disposal activities and ensure compliance with relevant environmental protection regulations.

1,4,7,10-tetrakis-(4-methylphenyl)sulfonyl-1,4,7,10-tetrazacyclododecane is classified as ADR Class 9 (miscellaneous dangerous goods), Packing Group III for transportation purposes. Use appropriate packaging that meets UN specification requirements for this classification. Ensure proper labeling with Class 9 hazard labels and correct shipping documentation. Vehicles must comply with ADR regulations for Class 9 substances. Drivers require appropriate ADR training certification, and emergency response information must be available during transport.

1,4,7,10-tetrakis-(4-methylphenyl)sulfonyl-1,4,7,10-tetrazacyclododecane is subject to standard EU chemical regulations under REACH and CLP but is not currently listed as a Substance of Very High Concern (SVHC). It must be classified and labeled according to CLP regulation with Warning signal word and appropriate GHS pictograms (GHS07, GHS09). Safety data sheets must be provided to downstream users, and standard REACH registration requirements apply depending on tonnage manufactured or imported annually.

1,4,7,10-tetrakis-(4-methylphenyl)sulfonyl-1,4,7,10-tetrazacyclododecane is available through OYSI, a specialized European distributor of chemical products serving research institutions and industrial customers. OYSI provides this compound with full regulatory compliance, proper documentation, and technical support across Europe. Contact OYSI directly for availability, specifications, and delivery options to your location. All products are supplied with comprehensive safety data sheets and certificates of analysis meeting European quality standards.