1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride
C8H13ClN2O2S
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Identification
- CAS Number
- 88918-84-7
- EC Number
- 406-010-5
- UN Number
- 3077
- Index Number
- 616-038-00-1
- PubChem CID
- 14234262
Physical-chemical properties
- Molecular Formula
- C8H13ClN2O2S
- Molar Mass
- 236.72 g/mol
- IUPAC Name
- 1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride
Chemical Identifiers
- InChI
- InChI=1S/C8H12N2O2S.ClH/c1-10-13(11,12)6-7-2-4-8(9)5-3-7;/h2-5,10H,6,9H2,1H3;1H
- InChI Key
- VKLYKCNYIYHJEY-UHFFFAOYSA-N
Overview
1-(4-aminophenyl)-N-methylmethanesulfonamide hydrochloride (CAS 88918-84-7) is an aromatic sulfonamide compound featuring both amino and methanesulfonamide functional groups. This specialized chemical intermediate represents an important class of substituted aniline derivatives with sulfonamide functionality. The compound consists of a para-aminophenyl ring system connected to an N-methylmethanesulfonamide group, supplied in its stable hydrochloride salt form. With the molecular formula C8H13ClN2O2S and a molecular weight of 236.72 g/mol, this white to off-white crystalline solid exhibits enhanced solubility and handling characteristics compared to its free base form. The presence of both amino and sulfonamide functional groups makes this compound particularly valuable as a synthetic intermediate in pharmaceutical and fine chemical manufacturing. Its structural similarity to other amino-substituted aromatics, such as 3-amino-4-hydroxy-N-(3-propan-2-yloxypropyl)benzenesulfonamide hydrochloride, positions it within a family of compounds used for advanced chemical synthesis applications. Safety considerations are paramount when handling this material, as it is classified with serious eye damage potential (Eye Dam. 1) and skin sensitization properties (Skin Sens. 1). The compound also presents aquatic chronic toxicity concerns (Aquatic Chronic 2), requiring appropriate environmental precautions during use and disposal. Transportation falls under ADR Class 9 miscellaneous dangerous substances. Primary industrial applications include pharmaceutical intermediate synthesis, specialty chemical manufacturing, and research and development activities in medicinal chemistry. The compound serves as a building block for more complex molecular structures in drug discovery programs and custom synthesis projects. OYSI maintains reliable supply chains for 1-(4-aminophenyl)-N-methylmethanesulfonamide hydrochloride to support European industrial and research customers with consistent quality and regulatory compliance.
Safety & Classification
Eye Dam. 1; Skin Sens. 1; Aquatic Chronic 2
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Skin Contact
Measures if substance contacts the skin
First Aid Actions
- +P302IF ON SKIN:
- +P352Wash with plenty of water.
- +P361Take off immediately all contaminated clothing.
- +P313Get medical advice/attention.
Related hazard statements:
Eye Contact
Measures if substance gets into the eyes
First Aid Actions
- +P305IF IN EYES:
- +P351Rinse cautiously with water for several minutes.
- +P338Remove contact lenses, if present and easy to do. Continue rinsing.
- +P313Get medical advice/attention.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 3077 |
| ADR Class | 9 |
| Packing Group | III |
| Tunnel Code | - |
| Proper Shipping Name | (4-Aminophenyl)-N-methyl-methylensulfonamid-hydrochlorid |
| Marine Pollutant | No |
Frequently Asked Questions
What is 1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride?
1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride is an organic chemical compound with the molecular formula C8H13ClN2O2S and CAS number 88918-84-7. This substance has a molecular weight of 236.72 g/mol and contains both aromatic amine and sulfonamide functional groups. It is classified as a hazardous substance requiring careful handling due to its potential for causing eye damage and skin sensitization.
What are the physicochemical properties of 1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride?
1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride is a solid compound at room temperature with a molecular weight of 236.72 g/mol. As a hydrochloride salt, it typically exhibits good water solubility compared to its free base form. The presence of both amino and sulfonamide groups contributes to its polar character and potential for hydrogen bonding interactions.
What is 1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride used for?
1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride is primarily used as a chemical intermediate in pharmaceutical and fine chemical synthesis. Its aromatic amine structure makes it valuable for developing various organic compounds through coupling reactions, derivatization, and as a building block for more complex molecules. It may also serve in research applications and specialized chemical manufacturing processes.
How to handle 1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride safely?
1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride requires careful handling with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid skin and eye contact due to its Eye Dam. 1 and Skin Sens. 1 classifications, and implement proper hygiene measures after handling.
How to store 1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride correctly?
1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride should be stored in a cool, dry place away from direct sunlight and moisture in tightly sealed containers. Keep the substance separated from incompatible materials and ensure proper labeling according to GHS requirements. Storage areas should be well-ventilated and equipped with appropriate spill containment measures to prevent environmental release.
What to do in case of contact with 1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride?
Immediate action is required for any contact with 1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride. For eye contact, flush immediately with plenty of water for at least 15 minutes and seek medical attention due to its Eye Dam. 1 classification. For skin contact, wash thoroughly with soap and water and remove contaminated clothing. If ingested or inhaled, seek immediate medical advice and provide the safety data sheet to medical personnel.
How to dispose of 1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride appropriately?
1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride must be disposed of through licensed hazardous waste management companies in accordance with local, national, and European waste regulations. The substance cannot be disposed of in regular waste streams due to its hazardous classification. Contaminated materials and empty containers should also be treated as hazardous waste and disposed of through appropriate channels.
How to transport 1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride?
1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride is classified as ADR Class 9 (miscellaneous dangerous substances), Packing Group III for transportation purposes. This classification requires appropriate packaging, labeling, and documentation according to ADR regulations. Transportation must be conducted by certified carriers familiar with hazardous materials handling, using proper packaging and shipping papers that comply with international dangerous goods regulations.
Is 1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride subject to specific regulations?
1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride is subject to European REACH and CLP regulations requiring proper registration, classification, and labeling. It is not currently listed as a Substance of Very High Concern (SVHC). Companies handling this substance must comply with workplace safety regulations, environmental protection laws, and maintain appropriate safety data sheets. Transportation is governed by ADR/RID regulations due to its Class 9 classification.
Where to buy 1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride in Europe?
1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride is available through OYSI, a specialized European distributor of technical chemicals and intermediates. OYSI provides this substance with full regulatory compliance, appropriate packaging, and complete documentation including safety data sheets. As a professional chemical distributor, OYSI ensures quality standards and regulatory compliance for industrial and research customers across Europe.
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1-(4-aminophenyl)-N-methylmethanesulfonamide;hydrochloride is a dangerous good. We support you with labeling, packaging, and transport documentation.
Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.