Ethyl 2-(2-acetamido-5-fluoro-4-isothiocyanatophenoxy)acetate

Ethyl 2-(2-acetamido-5-fluoro-4-isothiocyanatophenoxy)acetate is a specialized organic compound with CAS number 147379-38-2 and molecular formula C13H13FN2O4S. This fluorinated aromatic ester contains both acetamido and isothiocyanate functional groups, giving it unique chemical properties. With a molecular weight of 312.32 g/mol, it represents a complex synthetic intermediate used in specialized chemical applications requiring specific reactivity patterns.

Ethyl 2-(2-acetamido-5-fluoro-4-isothiocyanatophenoxy)acetate is a solid compound with molecular weight 312.32 g/mol and formula C13H13FN2O4S. The presence of fluorine and isothiocyanate groups influences its polarity and reactivity. As an ethyl ester, it likely exhibits moderate solubility in organic solvents. The compound's specific physical properties such as melting point, boiling point, and exact appearance should be confirmed through technical documentation for precise handling requirements.

Ethyl 2-(2-acetamido-5-fluoro-4-isothiocyanatophenoxy)acetate serves as a specialized chemical intermediate in pharmaceutical research and fine chemical synthesis. The isothiocyanate group makes it valuable for bioconjugation reactions and protein labeling applications. Its unique combination of functional groups enables its use in developing fluorinated pharmaceuticals, agrochemicals, or specialty materials where specific reactivity and fluorine incorporation are required for enhanced biological or chemical properties.

Safe handling of ethyl 2-(2-acetamido-5-fluoro-4-isothiocyanatophenoxy)acetate requires standard laboratory protective equipment including safety goggles, gloves, and lab coats. Work in well-ventilated areas or under fume hoods to avoid inhalation. The isothiocyanate group can be reactive with amines and proteins, so avoid skin contact. Use appropriate chemical-resistant gloves and ensure proper ventilation. Follow standard procedures for handling organic chemicals and maintain good laboratory hygiene practices.

Ethyl 2-(2-acetamido-5-fluoro-4-isothiocyanatophenoxy)acetate should be stored in a cool, dry place away from direct sunlight and heat sources. Keep containers tightly sealed to prevent moisture absorption and degradation. Store separately from strong bases, amines, and reducing agents due to the reactive isothiocyanate group. Maintain storage temperature as specified by the manufacturer and ensure proper labeling with hazard information. Use appropriate secondary containment to prevent environmental release.

Immediate action for skin contact with ethyl 2-(2-acetamido-5-fluoro-4-isothiocyanatophenoxy)acetate involves removing contaminated clothing and washing the affected area with plenty of soap and water for at least 15 minutes. For eye contact, rinse immediately with clean water for 15 minutes while holding eyelids open. If inhaled, move to fresh air immediately. Remove from exposure and seek medical attention if symptoms develop. Do not induce vomiting if ingested and seek immediate medical advice.

Proper disposal of ethyl 2-(2-acetamido-5-fluoro-4-isothiocyanatophenoxy)acetate requires treatment as hazardous waste due to its Aquatic Acute 1 and Aquatic Chronic 1 classifications. Never dispose of in regular trash or pour down drains. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Follow local and European waste regulations including proper classification, labeling, and documentation. Consider incineration at authorized facilities as an appropriate disposal method for organic compounds.

Transportation of ethyl 2-(2-acetamido-5-fluoro-4-isothiocyanatophenoxy)acetate follows ADR Class 9 regulations as a miscellaneous dangerous substance, Packing Group III. This classification requires appropriate UN-approved packaging, proper labeling with Class 9 hazard labels, and accompanying transport documentation. Ensure packages are securely sealed and marked with the correct shipping name and UN number. Follow ADR requirements for loading, segregation, and driver training when transporting this material.

Ethyl 2-(2-acetamido-5-fluoro-4-isothiocyanatophenoxy)acetate is subject to European CLP regulation with Warning signal word and GHS09 environmental pictogram due to its aquatic toxicity. It falls under REACH regulation for chemical registration and safety assessment. The compound is not currently listed as SVHC (Substance of Very High Concern). Users must comply with environmental protection measures and proper risk assessment procedures when handling this environmentally hazardous substance.

Ethyl 2-(2-acetamido-5-fluoro-4-isothiocyanatophenoxy)acetate is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides this compound to research institutions, pharmaceutical companies, and specialized chemical manufacturers across Europe. As a professional chemical distributor, OYSI ensures proper handling, documentation, and regulatory compliance for this specialized compound. Contact OYSI directly for availability, specifications, and regulatory documentation requirements for your specific application.