4-tritylmorpholine

C23H23NO

CAS1420-06-0
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
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Identification

CAS Number
1420-06-0
EC Number
215-812-2
UN Number
2588
Index Number
613-052-00-X
PubChem CID
14993

Physical-chemical properties

Molecular Formula
C23H23NO
Molar Mass
329.40 g/mol
IUPAC Name
4-tritylmorpholine

Chemical Identifiers

InChI
InChI=1S/C23H23NO/c1-4-10-20(11-5-1)23(21-12-6-2-7-13-21,22-14-8-3-9-15-22)24-16-18-25-19-17-24/h1-15H,16-19H2
InChI Key
ZJMLMBICUVVJDX-UHFFFAOYSA-N

Overview

4-tritylmorpholine (CAS 1420-06-0) is an organic morpholine derivative with significant chemical stability and distinctive protective group characteristics. This specialized chemical compound, also known by its IUPAC designation 4-tritylmorpholine, represents an important class of nitrogen-containing heterocyclic compounds widely utilized in pharmaceutical and chemical synthesis applications. With its molecular formula C23H23NO and molecular weight of 329.4 g/mol, this substance features a morpholine ring system protected by a trityl group, providing enhanced stability and selective reactivity patterns that make it particularly valuable in organic synthesis processes. The compound exhibits moderate acute toxicity characteristics, classified as Acute Tox. 4 under the GHS system, requiring appropriate handling precautions and safety measures during industrial use. Environmental considerations are particularly important, as 4-tritylmorpholine demonstrates both acute and chronic aquatic toxicity (Aquatic Acute 1; Aquatic Chronic 1), necessitating controlled discharge and waste management protocols. The substance carries Warning signal word designation with corresponding GHS07 and GHS09 pictograms, and falls under ADR transport class 6.1 for hazardous materials shipping requirements. In industrial applications, 4-tritylmorpholine serves primarily as a synthetic intermediate in pharmaceutical manufacturing, particularly in the development of complex drug molecules where selective protection and deprotection of amino functionalities is crucial. The compound also finds use in fine chemical synthesis and as a building block for specialized organic compounds. While structurally distinct from compounds like dimethoxy-(3-methyl-4-nitrophenoxy)-sulfanylidene-lambda5-phosphane, both substances share applications in sophisticated synthetic chemistry processes requiring precise molecular modifications. OYSI maintains reliable supply chains for 4-tritylmorpholine to support European chemical and pharmaceutical industries with consistent quality and technical support.

Safety & Classification

Warning
Classification:

Acute Tox. 4 *; Aquatic Acute 1; Aquatic Chronic 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H302

Harmful if swallowed.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2588
ADR Class6.1
Packing GroupIII
Tunnel CodeE
Proper Shipping NameTrifenmorph (ISO)
Marine PollutantNo

Frequently Asked Questions

What is 4-tritylmorpholine?

4-tritylmorpholine is an organic chemical compound with the molecular formula C23H23NO and CAS number 1420-06-0. This substance belongs to the morpholine family and features a trityl protecting group attached to the nitrogen atom. With a molecular weight of 329.4 g/mol, it is classified as moderately hazardous with acute toxicity category 4 and presents environmental risks to aquatic organisms.

What are the physicochemical properties of 4-tritylmorpholine?

4-tritylmorpholine is a solid organic compound at room temperature with a molecular weight of 329.4 g/mol. The compound contains both aromatic rings from the trityl group and the morpholine heterocycle, giving it specific solubility characteristics. Its physicochemical properties are influenced by the bulky trityl protecting group, which affects its reactivity and handling requirements in laboratory and industrial applications.

What is 4-tritylmorpholine used for?

4-tritylmorpholine is primarily used as an intermediate in organic synthesis and pharmaceutical manufacturing. The trityl group serves as a protecting group for the morpholine nitrogen, allowing selective chemical reactions at other positions. This compound is valuable in the synthesis of complex organic molecules, particularly in pharmaceutical research and development where controlled reactivity is essential for multi-step synthetic processes.

How to handle 4-tritylmorpholine safely?

4-tritylmorpholine requires careful handling due to its Acute Tox. 4 classification and environmental hazards. Wear appropriate personal protective equipment including gloves, safety glasses, and lab coats. Work in well-ventilated areas or under fume hoods to avoid inhalation. Prevent skin and eye contact, and avoid release to the environment due to its aquatic toxicity classification (GHS07 and GHS09 pictograms).

How to store 4-tritylmorpholine correctly?

4-tritylmorpholine should be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from incompatible materials. Keep containers properly labeled and segregated from food, feed, and drinking water. Due to its environmental hazard classification, ensure secondary containment to prevent accidental release. Store according to local regulations for hazardous chemicals and maintain inventory records for regulatory compliance.

What to do in case of contact with 4-tritylmorpholine?

In case of skin contact with 4-tritylmorpholine, immediately remove contaminated clothing and wash affected area thoroughly with soap and water. For eye contact, rinse immediately with plenty of clean water for at least 15 minutes. If inhaled, move to fresh air immediately. Due to its Acute Tox. 4 classification, seek medical attention if symptoms develop or in case of significant exposure.

How to dispose of 4-tritylmorpholine appropriately?

4-tritylmorpholine must be disposed of as hazardous waste according to local and national regulations. Due to its aquatic toxicity classification, prevent release to water systems or soil. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Do not pour down drains or dispose of with regular waste. Maintain disposal records for regulatory compliance and environmental protection requirements.

How to transport 4-tritylmorpholine?

4-tritylmorpholine is classified under ADR Class 6.1 (Toxic substances), Packing Group III for transportation. This classification requires specific packaging, labeling, and documentation for road transport in Europe. Use UN-approved packaging and ensure proper hazard labels are displayed. Drivers must have appropriate ADR training certificates, and transport documents must accompany shipments according to dangerous goods regulations.

Is 4-tritylmorpholine subject to specific regulations?

4-tritylmorpholine is subject to European chemical regulations including REACH and CLP. It is not currently listed as a SVHC (Substance of Very High Concern). The compound must comply with classification, labeling, and packaging requirements due to its hazard profile. Users must follow safety data sheet instructions and maintain exposure controls. Environmental release restrictions apply due to its aquatic toxicity classification.

Where to buy 4-tritylmorpholine in Europe?

4-tritylmorpholine is available through OYSI, a specialized European distributor of chemical products. As professional chemical suppliers, OYSI can provide this compound with proper documentation, safety data sheets, and regulatory compliance support. Contact OYSI for availability, technical specifications, and pricing information. They ensure proper packaging and transportation according to ADR Class 6.1 requirements for safe delivery across Europe.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.