3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline

C8H5Cl2F4NO

CAS104147-32-2
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
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Identification

CAS Number
104147-32-2
EC Number
401-790-3
UN Number
3077
Index Number
612-093-00-0
PubChem CID
5463763

Physical-chemical properties

Molecular Formula
C8H5Cl2F4NO
Molar Mass
278.03 g/mol
IUPAC Name
3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline

Chemical Identifiers

InChI
InChI=1S/C8H5Cl2F4NO/c9-4-1-3(15)2-5(10)6(4)16-8(13,14)7(11)12/h1-2,7H,15H2
InChI Key
JIPDPVQPKLVDIU-UHFFFAOYSA-N

Overview

3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline (CAS 104147-32-2) is a halogenated aromatic amine featuring both chlorine and tetrafluoroethoxy substituents on the benzene ring. This specialized chemical compound belongs to the family of substituted anilines, characterized by its unique combination of halogen atoms that impart distinctive properties. With a molecular formula of C8H5Cl2F4NO and molecular weight of 278.03 g/mol, this substance exhibits the structural complexity typical of advanced pharmaceutical and agrochemical intermediates. The presence of both chlorine atoms at the 3,5-positions and the tetrafluoroethoxy group at the 4-position creates a highly electronegative environment around the aromatic ring, influencing its reactivity and selectivity in chemical transformations. The compound is classified under multiple hazard categories, including Acute Toxicity Category 4 and Aquatic toxicity (both acute and chronic Category 1), requiring careful handling protocols and appropriate safety measures. The GHS07 and GHS09 pictograms indicate both health hazards and environmental concerns, while its ADR Class 9 designation categorizes it as a miscellaneous dangerous substance for transport purposes. Primary industrial applications include its use as an intermediate in pharmaceutical synthesis, particularly in the development of compounds requiring fluorinated aromatic building blocks. The agricultural sector also utilizes this substance in the production of specialized crop protection agents, where its unique substitution pattern provides enhanced biological activity. Unlike simpler compounds such as 2-N,4-N-diethyl-6-methylsulfanyl-1,3,5-triazine-2,4-diamine, this tetrafluoroethoxy derivative offers superior metabolic stability and selectivity in target applications. OYSI provides reliable access to 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline for qualified industrial customers across Europe, ensuring consistent quality and regulatory compliance for demanding applications.

Safety & Classification

Warning
Classification:

Acute Tox. 4 *; Aquatic Acute 1; Aquatic Chronic 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H302

Harmful if swallowed.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3077
ADR Class9
Packing GroupIII
Tunnel Code-
Proper Shipping Name3,5-Dichlor-4-(1,1,2,2-tetrafluorethoxy)anilin, fest
Marine PollutantNo

Frequently Asked Questions

What is 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline?

3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline is an organofluorine chemical compound with the molecular formula C8H5Cl2F4NO and CAS number 104147-32-2. This specialized aniline derivative features both chlorine and tetrafluoroethoxy substituents on the aromatic ring, giving it unique chemical properties. With a molecular weight of 278.03 g/mol, it belongs to the class of halogenated aromatic amines used primarily in industrial applications requiring fluorinated intermediates.

What are the physicochemical properties of 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline?

3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline is a halogenated aromatic compound with distinctive physicochemical characteristics due to its fluorine and chlorine substituents. The presence of multiple halogens typically results in increased density and altered solubility compared to unsubstituted anilines. The tetrafluoroethoxy group significantly influences the compound's polarity and intermolecular interactions. Specific physical properties such as melting point, boiling point, and exact appearance may vary and should be confirmed through technical specifications from the supplier.

What is 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline used for?

3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline serves as a specialized chemical intermediate in pharmaceutical and agrochemical synthesis. Its unique combination of chlorine and fluorine substituents makes it valuable for developing compounds requiring specific electronic and steric properties. The compound is typically used in research and development applications, custom synthesis projects, and as a building block for more complex fluorinated molecules. Its applications are primarily limited to professional industrial use due to its specialized nature.

How to safely handle 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline?

3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline requires careful handling due to its Acute Tox. 4 classification and Warning signal word. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods to minimize inhalation exposure. Avoid direct skin and eye contact, and prevent ingestion. Use appropriate engineering controls and follow standard laboratory safety protocols when handling this compound. Always consult the safety data sheet before use.

How should 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline be stored properly?

3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline should be stored in a cool, dry, well-ventilated area away from incompatible materials. Keep containers tightly closed and protected from light and moisture to prevent degradation. Store separately from strong oxidizing agents, acids, and bases due to potential incompatibilities. Maintain appropriate temperature conditions as specified by the supplier and ensure proper labeling according to GHS requirements. Regular inventory checks and proper segregation from other chemicals are essential for safe storage.

What to do in case of contact with 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline?

Immediate first aid measures for 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline exposure include thorough decontamination procedures. For skin contact, immediately remove contaminated clothing and wash affected area with plenty of soap and water for at least 15 minutes. In case of eye contact, flush with clean water for 15-20 minutes while holding eyelids open. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult medical professionals and provide the safety data sheet.

How to properly dispose of 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline?

3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline must be disposed of as hazardous waste through licensed waste management companies. Due to its environmental hazard classification (Aquatic Acute 1, Aquatic Chronic 1), it cannot be released into waterways or standard waste streams. Incineration at high temperatures in appropriate facilities is typically the preferred disposal method for halogenated organic compounds. Always comply with local, national, and EU waste regulations, and maintain proper documentation of disposal activities for regulatory compliance.

How to transport 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline?

3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline is classified as ADR Class 9 (Miscellaneous Dangerous Substances), Packing Group III for transportation purposes. This classification requires appropriate packaging, labeling, and documentation according to ADR regulations. Containers must be properly sealed and labeled with the correct hazard markings including GHS07 and GHS09 pictograms. Transportation should be handled by qualified carriers familiar with dangerous goods regulations, with proper shipping papers and emergency response information readily available during transit.

Is 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline subject to specific regulations?

3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline is subject to standard EU chemical regulations including REACH and CLP requirements. The compound is not currently identified as a Substance of Very High Concern (SVHC). It must be classified and labeled according to CLP regulation with appropriate hazard statements and precautionary measures. Users must comply with occupational exposure limits, environmental protection requirements, and proper risk assessment procedures. Registration or notification requirements under REACH may apply depending on quantities imported or manufactured annually.

Where to buy 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline in Europe?

3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)aniline is available through OYSI, a specialized European distributor of technical chemical products. OYSI provides reliable supply chain management for specialized chemicals to industrial and research customers across Europe. As a professional chemical distributor, OYSI ensures proper handling, documentation, and regulatory compliance for hazardous materials. Contact OYSI directly for availability, technical specifications, safety data sheets, and regulatory documentation required for your specific application and location within Europe.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.