2-(tetrazol-1-yl)acetic acid

2-(tetrazol-1-yl)acetic acid is an organic compound with the molecular formula C3H4N4O2 and CAS number 21732-17-2. This chemical belongs to the tetrazole family, characterized by a five-membered ring containing four nitrogen atoms and one carbon atom, linked to an acetic acid moiety. With a molecular weight of 128.09 g/mol, it serves as an important intermediate in pharmaceutical and chemical synthesis applications.

2-(tetrazol-1-yl)acetic acid is typically a white to off-white crystalline solid at room temperature. The compound contains both acidic carboxyl and nitrogen-rich tetrazole functionalities, making it polar and likely water-soluble due to its ability to form hydrogen bonds. Its molecular structure with multiple nitrogen atoms contributes to its stability and reactivity profile, though specific melting point and solubility data would require experimental determination.

2-(tetrazol-1-yl)acetic acid is primarily used as a synthetic intermediate in pharmaceutical research and development. The tetrazole ring system is valuable in medicinal chemistry as a bioisostere for carboxylic acids, offering improved metabolic stability and bioavailability. It serves as a building block for developing antihypertensive drugs, particularly angiotensin receptor antagonists, and other therapeutic compounds requiring tetrazole functionality in their molecular structure.

2-(tetrazol-1-yl)acetic acid should be handled with standard laboratory safety practices despite having no specific hazard classification. Wear appropriate personal protective equipment including safety glasses, laboratory gloves, and lab coats to prevent direct contact. Work in well-ventilated areas or under fume hoods to avoid inhalation of dust particles. Use proper laboratory techniques when weighing and transferring the material to minimize exposure and contamination risks.

2-(tetrazol-1-yl)acetic acid should be stored in a cool, dry place away from direct sunlight and heat sources. Keep the material in tightly sealed containers to prevent moisture absorption and contamination. Store at room temperature in a well-ventilated area, separated from strong oxidizing agents and incompatible materials. Ensure proper labeling with substance name, CAS number, and storage date for inventory management and traceability purposes.

In case of skin contact with 2-(tetrazol-1-yl)acetic acid, immediately wash the affected area with plenty of water and soap for at least 15 minutes. For eye contact, rinse thoroughly with clean water for several minutes and remove contact lenses if present and easily removable. If inhaled, move to fresh air immediately. Although no specific hazards are classified, seek medical attention if irritation persists or if large quantities were involved in the exposure.

2-(tetrazol-1-yl)acetic acid should be disposed of according to local and national waste regulations for pharmaceutical intermediates and organic chemicals. Contact licensed waste disposal companies specialized in chemical waste management. Do not discharge into drains, soil, or water systems. Small laboratory quantities may be collected with other organic waste for incineration at appropriate facilities, while larger amounts require specific disposal protocols and documentation.

2-(tetrazol-1-yl)acetic acid can be transported as a non-hazardous material since it has no specific ADR classification requirements. However, use appropriate packaging to prevent spillage and contamination during transit. Ensure containers are properly sealed and labeled with the chemical name and CAS number. Follow general good practices for chemical transport, including proper documentation and handling instructions for the receiving party.

2-(tetrazol-1-yl)acetic acid is subject to standard REACH registration requirements for chemicals manufactured or imported in the European Union above certain tonnage thresholds. It is not classified as a SVHC (Substance of Very High Concern) and has no specific GHS hazard classification. However, it must comply with general chemical safety regulations, proper labeling requirements, and safety data sheet provisions under CLP regulation.

2-(tetrazol-1-yl)acetic acid is available through OYSI, a specialized European distributor of pharmaceutical intermediates and fine chemicals. OYSI provides high-quality chemical products to research institutions, pharmaceutical companies, and chemical manufacturers across Europe. Contact OYSI directly for availability, specifications, packaging options, and technical support. As a professional chemical distributor, OYSI ensures proper documentation, regulatory compliance, and reliable supply chains for specialized compounds.