(2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol

C17H12Cl2N2O

CAS60168-88-9
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
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Identification

CAS Number
60168-88-9
EC Number
262-095-7
UN Number
3077
Index Number
603-104-00-X
PubChem CID
43226

Physical-chemical properties

Molecular Formula
C17H12Cl2N2O
Molar Mass
331.20 g/mol
IUPAC Name
(2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol

Chemical Identifiers

InChI
InChI=1S/C17H12Cl2N2O/c18-14-7-5-12(6-8-14)17(22,13-9-20-11-21-10-13)15-3-1-2-4-16(15)19/h1-11,22H
InChI Key
NHOWDZOIZKMVAI-UHFFFAOYSA-N

Overview

(2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol (CAS 60168-88-9) is an organochlorine compound with dual chlorinated phenyl groups attached to a pyrimidine ring system. This specialized chemical compound, also designated by EC number 262-095-7, represents a complex aromatic molecule with a molecular formula of C17H12Cl2N2O and molecular weight of 331.2 g/mol. The structure features two distinct chlorophenyl substituents positioned on a central pyrimidin-5-ylmethanol framework, creating a molecule with unique chemical properties and specific industrial applications. From a safety perspective, this substance requires careful handling protocols due to its classification as a reproductive toxicant category 2 and potential lactation hazard, indicated by the GHS08 health hazard pictogram. Additionally, its aquatic chronic toxicity classification 2 and corresponding GHS09 environmental pictogram highlight the importance of proper environmental protection measures during storage, handling, and disposal. The substance falls under ADR class 9 for transportation purposes, requiring appropriate shipping documentation and packaging. In industrial applications, (2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol serves primarily as an intermediate in pharmaceutical synthesis and specialized chemical manufacturing processes. Its unique molecular architecture makes it valuable for developing compounds with specific biological activities. The compound shares certain structural characteristics with other organochlorine intermediates, though it differs significantly from simpler molecules like propan-2-yl N-(3-chlorophenyl)carbamate in terms of complexity and application scope. Quality control and regulatory compliance are essential when working with this compound, given its reproductive toxicity classification and environmental considerations. OYSI maintains this specialized chemical intermediate to support European industrial customers requiring high-purity organochlorine compounds for advanced chemical synthesis applications.

Safety & Classification

Warning
Classification:

Repr. 2; Lact.; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H362

May cause harm to breast-fed children.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Transport (ADR)

UN Number3077
ADR Class9
Packing GroupIII
Tunnel Code-
Proper Shipping NameFenarimol (ISO)
Marine PollutantNo

Frequently Asked Questions

What is (2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol?

(2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol is an organic chemical compound with the molecular formula C17H12Cl2N2O and CAS number 60168-88-9. This compound features a pyrimidine ring structure with two chlorinated phenyl groups and a methanol group, resulting in a molecular weight of 331.2 g/mol. It is classified as a reproductive toxicant category 2 and presents aquatic chronic toxicity category 2 hazards.

What are the physicochemical properties of (2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol?

(2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol is a solid organic compound at room temperature with a molecular weight of 331.2 g/mol. The compound contains two chlorine atoms and has both aromatic and heterocyclic structural components. Its solubility characteristics and specific physical properties such as melting point and appearance may vary depending on purity and crystalline form, requiring consultation of detailed product specifications for precise data.

What is (2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol used for?

(2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol is primarily used as a chemical intermediate in pharmaceutical and fine chemical synthesis. Its pyrimidine-based structure makes it valuable for developing biologically active compounds and research applications. The compound may serve as a building block in medicinal chemistry research and pharmaceutical manufacturing processes, where its specific molecular structure contributes to the development of targeted therapeutic agents.

How to handle (2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol safely?

(2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol requires careful handling due to its reproductive toxicity classification. Operators must wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume extraction. Avoid inhalation, skin contact, and ingestion. Due to its reproductive hazard classification, pregnant women and nursing mothers should avoid exposure to this substance.

How to store (2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol correctly?

(2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from incompatible materials. Storage areas must be secure and restricted to authorized personnel due to the reproductive toxicity hazards. The compound should be kept away from sources of ignition and protected from moisture and direct sunlight. Regular inspection of container integrity is recommended to prevent leakage.

What to do in case of contact with (2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol?

Immediate action is required upon contact with (2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol. For skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water. In case of eye contact, flush immediately with clean water for at least 15 minutes. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician and provide the safety data sheet.

How to dispose of (2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol properly?

(2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol must be disposed of as hazardous waste in accordance with local and European regulations. The compound cannot be disposed of in regular waste streams due to its reproductive toxicity and environmental hazard classification. Disposal must be performed by licensed hazardous waste contractors through approved incineration or chemical treatment facilities. Empty containers may also require special handling as hazardous waste.

How to transport (2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol?

(2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol is classified as ADR Class 9 (Miscellaneous dangerous substances), Packing Group III for transport purposes. This classification requires specific packaging, labeling, and documentation for road transport. Shipments must comply with ADR regulations including proper packaging specifications, hazard labels, and transport documentation. Only qualified carriers with appropriate permits should handle the transportation of this regulated substance across European borders.

Is (2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol subject to specific regulations?

(2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol is subject to CLP regulation classification as Repr. 2 and Lact., requiring GHS08 and GHS09 pictograms with 'Warning' signal word. The compound falls under REACH regulation for chemical registration and evaluation in Europe. While not currently listed as SVHC, its reproductive toxicity classification requires compliance with occupational exposure limits and special handling procedures in workplace environments.

Where to buy (2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol in Europe?

(2-chlorophenyl)-(4-chlorophenyl)-pyrimidin-5-ylmethanol is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides reliable supply chains for research institutions, pharmaceutical companies, and chemical manufacturers across Europe. As an established chemical distributor, OYSI ensures proper handling, documentation, and regulatory compliance for this controlled substance, supporting customers with technical expertise and regulatory guidance for safe procurement and use.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.