1,4,7,10-tetrazacyclododecane

1,4,7,10-tetrazacyclododecane is a cyclic organic compound with the molecular formula C8H20N4 and CAS number 294-90-6. This tetrazacyclic molecule features a twelve-membered ring containing four nitrogen atoms positioned at the 1, 4, 7, and 10 positions. With a molecular weight of 172.27 g/mol, it belongs to the family of macrocyclic ligands and is classified as a hazardous substance requiring careful handling due to its corrosive and toxic properties.

1,4,7,10-tetrazacyclododecane is a solid crystalline compound at room temperature with high solubility in water due to its nitrogen-containing structure. The molecule exhibits basic properties owing to the presence of four nitrogen atoms capable of protonation. Its cyclic structure provides conformational flexibility, and the compound shows good stability under normal conditions. The presence of multiple nitrogen atoms makes it an excellent chelating agent for various metal ions.

1,4,7,10-tetrazacyclododecane is primarily used as a chelating agent and ligand in coordination chemistry applications. It serves as a precursor for synthesizing metal complexes used in catalysis, medical imaging agents, and pharmaceutical research. The compound finds applications in analytical chemistry for metal ion extraction and separation processes. Additionally, it is utilized in research laboratories for developing new materials and studying coordination compounds with potential therapeutic applications.

1,4,7,10-tetrazacyclododecane requires careful handling due to its Skin Corr. 1B and Acute Tox. 4 classifications. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid direct skin and eye contact, and ensure emergency washing facilities are readily available. Handle only the minimum quantities necessary and follow established laboratory safety protocols.

1,4,7,10-tetrazacyclododecane should be stored in tightly sealed, corrosion-resistant containers in a cool, dry, and well-ventilated area. Keep away from incompatible materials such as strong acids and oxidizing agents. Storage areas must be equipped with appropriate spill containment measures and be accessible only to trained personnel. Maintain storage temperatures within recommended ranges and regularly inspect containers for signs of deterioration. Ensure proper labeling and inventory management according to local regulations.

Immediate action is required due to the compound's corrosive nature. For skin contact, immediately remove contaminated clothing and flush the affected area with copious amounts of water for at least 15 minutes. In case of eye contact, rinse immediately with water for at least 15 minutes while holding eyelids open. If inhaled, move the person to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician after any exposure incident.

1,4,7,10-tetrazacyclododecane must be disposed of as hazardous waste through licensed waste management companies due to its corrosive and toxic properties. Never dispose of this compound through regular waste streams or pour it down drains. Collect waste in appropriate, labeled containers and maintain detailed waste records. Disposal methods must comply with local, national, and EU waste regulations. Consider neutralization or treatment options where applicable before final disposal to minimize environmental impact.

1,4,7,10-tetrazacyclododecane is classified as ADR Class 8 (corrosive substances), Packing Group II, requiring specialized transport procedures. Use UN-approved packaging suitable for corrosive materials and ensure proper labeling with hazard diamonds and transport documentation. Vehicles must carry appropriate emergency equipment and drivers need ADR certification. Transport should follow designated routes where possible, and emergency response information must be readily available during transit. Comply with all applicable transport regulations.

1,4,7,10-tetrazacyclododecane is subject to EU REACH regulation requiring registration for import/manufacture above certain tonnages, though it is not currently listed as a Substance of Very High Concern (SVHC). The compound falls under CLP regulation for classification and labeling requirements. Users must comply with occupational exposure limits, waste disposal regulations, and transport ADR requirements. Regular safety data sheet updates and risk assessments are mandatory for commercial use within the European Union.

1,4,7,10-tetrazacyclododecane is available through OYSI, a specialized European distributor of technical chemicals serving industrial and research customers. OYSI provides this compound with complete documentation including safety data sheets, certificates of analysis, and regulatory compliance information. As a professional chemical supplier, OYSI ensures proper packaging, labeling, and transport in accordance with European regulations. Contact OYSI directly for availability, specifications, and technical support for your specific application requirements.