1,4,7,10-tetrazacyclododecane

1,4,7,10-tetrazacyclododecane is a macrocyclic organic compound with the molecular formula C8H20N4 and CAS number 294-90-6. This cyclen derivative features a twelve-membered ring containing four nitrogen atoms positioned at regular intervals. With a molecular weight of 172.27 g/mol, it belongs to the family of tetraazamacrocycles and serves as an important building block in coordination chemistry and pharmaceutical applications.

1,4,7,10-tetrazacyclododecane is typically a white to off-white crystalline solid at room temperature. The compound exhibits good solubility in polar solvents such as water and alcohols due to its multiple nitrogen atoms capable of hydrogen bonding. It has a relatively high melting point characteristic of cyclic amines and demonstrates stability under normal storage conditions, though it requires careful handling due to its corrosive properties.

1,4,7,10-tetrazacyclododecane is primarily used as a chelating ligand in coordination chemistry and as a precursor for contrast agents in medical imaging. It serves as a key intermediate in pharmaceutical synthesis, particularly for MRI contrast media production. The compound is also employed in research applications for metal ion complexation studies and as a building block for specialized chemical synthesis in academic and industrial laboratories.

1,4,7,10-tetrazacyclododecane requires careful handling due to its corrosive nature (Skin Corr. 1B) and acute toxicity (Acute Tox. 4). Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods to prevent inhalation. Avoid direct skin and eye contact, and ensure emergency shower and eyewash stations are readily accessible during handling operations.

1,4,7,10-tetrazacyclododecane should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep containers upright and properly labeled with hazard information. Store separately from acids, oxidizing agents, and other reactive chemicals. Maintain storage temperatures within recommended ranges and ensure containers are made of compatible materials to prevent degradation or dangerous reactions.

Immediate action is required due to the corrosive nature of 1,4,7,10-tetrazacyclododecane. For skin contact, immediately flush with copious amounts of water for at least 15 minutes and remove contaminated clothing. For eye contact, rinse immediately with water for at least 15 minutes and seek medical attention. If inhaled, move to fresh air and monitor breathing. Seek immediate medical attention for all exposure incidents and provide safety data sheet information to medical personnel.

1,4,7,10-tetrazacyclododecane must be disposed of as hazardous chemical waste in accordance with local, national, and EU regulations. Contact licensed waste disposal companies specializing in chemical waste management. Never dispose of through regular drainage systems due to its aquatic toxicity classification. Ensure proper waste categorization, documentation, and chain of custody procedures. Small laboratory quantities may require neutralization before disposal, following institutional waste management protocols.

1,4,7,10-tetrazacyclododecane is classified as ADR Class 8 (corrosive substances), Packing Group II, requiring specialized transport procedures. Packages must bear appropriate hazard labels including corrosive substance markings and proper shipping names. Use UN-approved packaging designed for corrosive materials. Transport vehicles must carry appropriate emergency equipment and documentation. Only trained personnel should handle transportation, and shipments must comply with ADR regulations for dangerous goods transport.

1,4,7,10-tetrazacyclododecane is subject to CLP regulation for classification and labeling as a corrosive and toxic substance. It falls under REACH registration requirements for chemical substances in the EU. While not currently listed as an SVHC (Substance of Very High Concern), its aquatic toxicity classification requires compliance with environmental protection regulations. Users must maintain safety data sheets and implement appropriate risk management measures according to EU chemical legislation.

1,4,7,10-tetrazacyclododecane is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides this compound to research institutions, pharmaceutical companies, and industrial customers across Europe with full regulatory compliance and proper documentation. As a professional chemical distributor, OYSI ensures product quality, appropriate packaging, and adherence to transport regulations for safe delivery to customers throughout the European market.