Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate

Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate is a synthetic organic compound belonging to the naphthyridine family with the molecular formula C17H10ClF3N2O3. This fluorinated heterocyclic compound has a molecular weight of 382.7 g/mol and is identified by CAS number 100491-29-0. It contains multiple halogen substituents (chlorine and fluorine atoms) and features both carboxylate ester and ketone functional groups, making it a complex pharmaceutical intermediate.

Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate is typically a crystalline solid at room temperature due to its rigid naphthyridine structure. The presence of multiple fluorine atoms and aromatic rings contributes to its stability and moderate lipophilicity. The compound's solubility profile is influenced by the polar carboxylate ester group and halogen substituents, generally showing better solubility in organic solvents than in water. Its melting point and other specific physical properties depend on the crystal form and purity.

Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate is primarily used as a pharmaceutical intermediate in the synthesis of quinolone and naphthyridine-based compounds. Its structural features make it valuable for developing antimicrobial agents, particularly fluoroquinolone antibiotics. The compound serves as a key building block in medicinal chemistry research and pharmaceutical manufacturing. It may also find applications in agrochemical synthesis and specialized organic chemistry research requiring fluorinated heterocyclic compounds.

Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate is classified as Skin Sens. 1, requiring careful handling to prevent skin sensitization. Mandatory personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods to minimize inhalation exposure. Avoid direct skin and eye contact, and prevent dust generation during handling. The Warning signal word indicates moderate hazard level, but proper safety protocols must be strictly followed to prevent sensitization reactions.

Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate should be stored in tightly sealed containers in a cool, dry place away from direct sunlight and heat sources. The storage area must be well-ventilated and equipped with appropriate containment measures due to its Aquatic Chronic 2 classification. Keep away from incompatible materials such as strong oxidizing agents and bases. Store separately from food, beverages, and animal feeding stuffs. Maintain inventory records and implement proper labeling according to GHS requirements with GHS07 and GHS09 pictograms.

In case of skin contact with ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, rinse immediately with plenty of clean water for at least 15 minutes while holding eyelids open. If inhaled, move the person to fresh air immediately. Seek medical attention promptly, especially for skin contact due to the skin sensitization potential. Do not induce vomiting if swallowed and seek immediate medical advice.

Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate must be disposed of as hazardous chemical waste through licensed waste disposal contractors in accordance with local and European waste regulations. The compound's Aquatic Chronic 2 classification prohibits discharge into water systems or sewers. Contaminated packaging should be treated as hazardous waste. Incineration at authorized high-temperature facilities is typically the preferred disposal method. Maintain proper waste documentation and follow the European Waste Catalogue (EWC) codes for halogenated organic compounds.

Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate is classified under ADR Class 9 (Miscellaneous dangerous goods), Packing Group III, indicating moderate danger during transport. Packages must comply with UN specification packaging requirements and bear appropriate hazard labels including GHS07 and GHS09 pictograms. Transport documents must include proper shipping names, hazard identification numbers, and emergency response information. Vehicles must carry appropriate emergency equipment, and drivers require ADR training certification. Ensure packages are secured and protected from damage during transit.

Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate is subject to European REACH regulation for chemical registration and evaluation, and CLP regulation for classification and labeling with GHS07 and GHS09 pictograms. The compound is not currently listed as a Substance of Very High Concern (SVHC). As a pharmaceutical intermediate, it may be subject to additional pharmaceutical manufacturing regulations and Good Manufacturing Practice (GMP) requirements. Users must maintain safety data sheets and comply with occupational exposure limits and environmental protection measures.

Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides this compound with full regulatory compliance, including proper CLP labeling, safety data sheets, and REACH documentation. As a professional chemical distributor, OYSI ensures quality standards and regulatory compliance for industrial and research applications. Contact OYSI directly for availability, technical specifications, packaging options, and delivery throughout Europe for your pharmaceutical intermediate requirements.