Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate

Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate is a fluorinated organic compound belonging to the naphthyridine family. With the molecular formula C17H10ClF3N2O3 and CAS number 100491-29-0, this substance has a molecular weight of 382.7 g/mol. It contains multiple halogen atoms (chlorine and fluorine) and features a complex heterocyclic structure with both carbonyl and ester functional groups.

Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate is typically a solid compound at room temperature due to its complex aromatic structure. The presence of multiple fluorine atoms and the extended conjugated system suggest limited water solubility but potential solubility in organic solvents. The compound's high molecular weight (382.7 g/mol) and multiple halogen substituents influence its physical properties and stability.

Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate is primarily used in pharmaceutical research and development as an intermediate compound. Its naphthyridine structure makes it valuable for medicinal chemistry applications, particularly in the synthesis of antimicrobial agents. The compound serves as a building block in organic synthesis and may be utilized in the development of fluoroquinolone-related pharmaceuticals or other bioactive molecules.

Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate requires careful handling due to its skin sensitization properties (Skin Sens. 1). Always wear protective gloves, safety glasses, and appropriate clothing to prevent skin contact. Work in well-ventilated areas or under fume hoods. Avoid creating dust or aerosols. The substance carries a Warning signal word and requires standard laboratory safety protocols to prevent sensitization reactions.

Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate should be stored in tightly sealed containers in a cool, dry place away from direct sunlight. Keep the substance in its original packaging and ensure proper labeling with hazard information. Store separately from incompatible materials and maintain controlled access to prevent unauthorized handling. Regular inspection of storage conditions helps maintain product integrity and safety compliance.

Immediate skin contact with ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate requires thorough washing with soap and water for at least 15 minutes. Remove contaminated clothing immediately. For eye contact, rinse with clean water for 15 minutes and seek medical attention. If inhaled, move to fresh air. Given its skin sensitization properties, seek medical advice if irritation persists or allergic reactions develop.

Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate must be disposed of through authorized hazardous waste management companies in accordance with local and European regulations. Due to its environmental hazard classification (Aquatic Chronic 2), prevent release into water systems. Small laboratory quantities may require incineration at approved facilities. Always consult local waste management authorities and follow institutional waste disposal protocols for halogenated organic compounds.

Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate is classified as ADR Class 9 (Miscellaneous dangerous substances), Packing Group III. Transport requires appropriate packaging that meets UN specification requirements and proper hazard labeling. Shipping documents must include the correct technical name and hazard classification. Professional carriers experienced in chemical transportation should handle shipments to ensure regulatory compliance and safety during transit.

Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate is subject to standard EU chemical regulations including REACH and CLP classifications. The substance is not identified as an SVHC (Substance of Very High Concern) but requires compliance with skin sensitization and environmental hazard labeling requirements. Users must follow workplace exposure guidelines and implement appropriate risk management measures according to safety data sheet recommendations.

Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylate is available through OYSI, a specialized European distributor of fine chemicals and pharmaceutical intermediates. OYSI provides high-quality chemical products with proper documentation including safety data sheets and certificates of analysis. Contact OYSI directly for availability, specifications, and delivery options across European markets. Professional customers can access this specialty compound through OYSI's established distribution network.