Benzyl carbonochloridate

Benzyl carbonochloridate is an organic chemical compound with the molecular formula C8H7ClO2 and CAS number 501-53-1. It belongs to the chloroformate family and has a molecular weight of 170.59 g/mol. This substance is classified as highly corrosive and environmentally hazardous, requiring careful handling and storage. It appears as a colorless to pale yellow liquid and is primarily used as a reactive intermediate in organic synthesis and pharmaceutical manufacturing.

Benzyl carbonochloridate is a colorless to pale yellow liquid at room temperature with a pungent, irritating odor. It has a molecular weight of 170.59 g/mol and is highly reactive with water, leading to hydrolysis and formation of hydrochloric acid. The substance is soluble in organic solvents but reacts violently with water and alcohols. It has a relatively low boiling point and can decompose upon heating, releasing toxic chlorine-containing gases.

Benzyl carbonochloridate is primarily used as a protecting group reagent in organic synthesis, particularly for amino acids and peptides in pharmaceutical research. It serves as an intermediate in the production of pharmaceuticals, agrochemicals, and fine chemicals. The compound is commonly employed in the synthesis of carbobenzoxy-protected amino acids and in peptide chemistry. It also finds applications in the manufacture of specialty polymers and as a derivatizing agent in analytical chemistry.

Benzyl carbonochloridate must be handled with extreme caution due to its corrosive nature (Skin Corr. 1B classification). Essential personal protective equipment includes chemical-resistant gloves, safety goggles, face shield, and protective clothing. Work must be conducted in a well-ventilated area or under a fume hood to prevent inhalation exposure. Avoid contact with water, alcohols, and bases as violent reactions may occur. Emergency eyewash and safety shower facilities should be readily accessible during handling operations.

Benzyl carbonochloridate must be stored in tightly sealed, corrosion-resistant containers in a cool, dry, well-ventilated area away from heat sources and ignition. Keep the substance separated from water, alcohols, amines, and bases to prevent dangerous reactions. Storage areas should be equipped with appropriate containment measures and emergency response equipment. The container should be kept in secondary containment to prevent environmental release. Temperature should be maintained below 25°C to ensure stability.

Benzyl carbonochloridate contact requires immediate action due to its corrosive properties. For skin contact, immediately remove contaminated clothing and flush the affected area with copious amounts of water for at least 15 minutes. In case of eye contact, rinse immediately with water for at least 15 minutes while holding eyelids open. If inhaled, move the person to fresh air immediately. Seek immediate medical attention for all exposure routes. Do not induce vomiting if ingested.

Benzyl carbonochloridate disposal must comply with local and national hazardous waste regulations due to its corrosive and environmentally hazardous properties. The substance should be collected in appropriate containers and disposed of through licensed hazardous waste disposal facilities. Small quantities can be carefully hydrolyzed under controlled conditions by qualified personnel, but this should only be done with proper safety measures. Never dispose of this substance down drains or in regular waste streams due to its aquatic toxicity classification.

Benzyl carbonochloridate is classified as ADR Class 8 (corrosive substances), Packing Group I, indicating high danger during transport. It must be packaged in UN-approved containers suitable for corrosive liquids and labeled with appropriate hazard placards including GHS05 and GHS09 pictograms. Transport vehicles must carry emergency response information and appropriate spill control materials. Only trained personnel should handle the transportation, and all ADR/IMDG regulations must be strictly followed for road, rail, or sea transport.

Benzyl carbonochloridate is subject to REACH regulation in Europe and must comply with CLP classification requirements. While not currently listed as a SVHC (Substance of Very High Concern), its corrosive properties and environmental hazard classifications require strict compliance with occupational health and safety regulations. Users must maintain safety data sheets, implement appropriate risk management measures, and may need to register usage depending on quantities. Local environmental permits may be required for industrial use due to its aquatic toxicity.

Benzyl carbonochloridate is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides this corrosive substance with full regulatory compliance, including proper documentation, safety data sheets, and appropriate packaging for safe transport. As an established chemical distributor, OYSI ensures that all products meet European quality standards and regulatory requirements. Contact OYSI directly to discuss your specific requirements, quantities needed, and to obtain current pricing and delivery information for benzyl carbonochloridate.