Benzyl carbonochloridate

Benzyl carbonochloridate is an organic chemical compound with the molecular formula C8H7ClO2 and CAS number 501-53-1. This substance belongs to the chloroformate family and has a molecular weight of 170.59 g/mol. It is classified as a highly corrosive material that poses significant risks to skin and aquatic environments, requiring careful handling and specialized safety measures in industrial applications.

Benzyl carbonochloridate is a liquid chemical compound that typically appears as a colorless to pale yellow solution. It has a pungent, irritating odor characteristic of chloroformates. The substance is reactive with water and moisture, leading to hydrolysis reactions. It has limited solubility in water due to its reactive nature but is generally soluble in organic solvents such as dichloromethane and toluene.

Benzyl carbonochloridate is primarily used as a protecting group reagent in organic synthesis, particularly for amino acids and peptides. It serves as an intermediate in pharmaceutical manufacturing and fine chemical synthesis. The compound is valuable in the production of carbamate derivatives and is commonly employed in research laboratories for organic chemistry applications where selective protection of amine groups is required.

Benzyl carbonochloridate must be handled with extreme caution due to its corrosive nature (Skin Corr. 1B classification). Essential personal protective equipment includes chemical-resistant gloves, safety goggles, face shield, and protective clothing. Work should be conducted in a well-ventilated fume hood to prevent inhalation exposure. Avoid contact with skin, eyes, and clothing, and ensure emergency shower and eyewash stations are readily accessible.

Benzyl carbonochloridate should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Keep containers away from moisture and water to prevent hydrolysis reactions. Store separately from incompatible materials such as alcohols, amines, and strong bases. Ensure storage areas have appropriate spill containment measures and are accessible only to trained personnel with proper safety equipment.

Immediate action is critical due to the corrosive nature of benzyl carbonochloridate. For skin contact, immediately remove contaminated clothing and flush affected area with plenty of water for at least 15 minutes. For eye contact, rinse immediately with water for at least 15 minutes while holding eyelids open. If inhaled, move to fresh air immediately. Seek immediate medical attention in all cases of exposure and provide safety data sheet to medical personnel.

Benzyl carbonochloridate must be disposed of as hazardous waste according to local and national environmental regulations. The substance cannot be disposed of in regular waste streams due to its corrosive and aquatic toxicity properties. Contact licensed hazardous waste disposal companies for proper collection and treatment. Small laboratory quantities may require neutralization under controlled conditions before disposal, following institutional waste management protocols.

Benzyl carbonochloridate is classified as ADR Class 8 (corrosive substances) Packing Group I, indicating high danger level for transport. It requires specialized hazardous materials packaging, labeling with GHS05 and GHS09 pictogramms, and proper shipping documentation. Transportation must comply with ADR regulations for corrosive materials, including use of appropriate containers, vehicle marking, and trained personnel. Only certified carriers should handle the transport of this substance.

Benzyl carbonochloridate is subject to various European chemical regulations including REACH registration requirements and CLP classification standards. It carries the signal word 'Danger' and is classified as Skin Corr. 1B and Aquatic Acute/Chronic 1. While not listed as a SVHC substance, it requires compliance with occupational safety regulations and environmental protection measures due to its hazardous properties and aquatic toxicity profile.

Benzyl carbonochloridate is available through OYSI, a specialized European distributor of technical chemicals. As an established chemical supplier, OYSI provides this substance to qualified industrial and research customers across Europe. Due to the hazardous nature of this compound, purchases typically require demonstration of proper handling capabilities, safety equipment, and waste disposal arrangements. Contact OYSI directly for availability, technical specifications, and regulatory documentation.