(2S)-6-fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-chromene

(2S)-6-fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-chromene is an organic compound with the molecular formula C11H11FO2 and CAS number 793669-26-8. This chiral molecule features a chromene backbone with a fluorine substituent and an epoxide group, giving it a molecular weight of 194.2 g/mol. The compound contains two stereocenters, indicated by the (2S) and (2R) stereochemical descriptors, making it an optically active substance with specific three-dimensional arrangement.

(2S)-6-fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-chromene is a solid organic compound at room temperature with a molecular weight of 194.2 g/mol. The presence of the fluorine atom and epoxide ring influences its chemical reactivity and physical properties. The chromene structure provides aromatic stability while the epoxide group makes it susceptible to ring-opening reactions. Specific data regarding melting point, boiling point, and solubility characteristics would require detailed analytical testing.

(2S)-6-fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-chromene is primarily used as an intermediate in pharmaceutical synthesis and fine chemical manufacturing. The compound's unique structural features, including the fluorinated chromene core and reactive epoxide group, make it valuable for developing bioactive molecules. Its chiral nature makes it particularly useful in stereoselective synthesis processes where specific optical activity is required for the final pharmaceutical or agrochemical products.

(2S)-6-fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-chromene should be handled with standard laboratory safety precautions including wearing appropriate personal protective equipment. Use chemical-resistant gloves, safety goggles, and work in a well-ventilated area or fume hood. Avoid direct skin contact and inhalation. The compound does not carry specific hazard pictograms for human health, but the presence of the reactive epoxide group suggests potential for causing irritation. Always follow good laboratory practices and handle with care.

(2S)-6-fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-chromene should be stored in a cool, dry place away from direct sunlight and heat sources. Keep containers tightly closed to prevent contamination and moisture absorption. Due to the reactive epoxide group, avoid storage near strong acids or bases that could catalyze ring-opening reactions. Store in appropriate chemical storage areas with adequate ventilation. The compound is classified as Aquatic Chronic 2, so prevent environmental release during storage.

In case of skin contact with (2S)-6-fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-chromene, immediately wash the affected area with plenty of water for at least 15 minutes. Remove contaminated clothing. For eye contact, rinse thoroughly with water for several minutes and seek medical attention if irritation persists. If inhaled, move to fresh air immediately. In case of accidental ingestion, do not induce vomiting and seek immediate medical attention. Always consult the safety data sheet for detailed emergency procedures.

(2S)-6-fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-chromene must be disposed of as hazardous chemical waste through licensed waste disposal companies. Due to its Aquatic Chronic 2 classification, it poses environmental risks and cannot be disposed of through regular waste streams or released into waterways. Contact authorized chemical waste disposal services that can handle organic compounds. Follow local and national regulations for hazardous waste disposal, including proper labeling and documentation of waste containers.

(2S)-6-fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-chromene is classified as ADR Class 9 (Miscellaneous dangerous substances), Packing Group III for transportation purposes. This classification indicates it poses a relatively lower transport risk compared to more hazardous materials. Use appropriate packaging that meets UN specification requirements for Class 9 substances. Ensure proper labeling with the correct shipping name, UN number, and hazard class. Transport should be handled by qualified carriers familiar with chemical transport regulations.

(2S)-6-fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-chromene is subject to REACH regulation in Europe and CLP classification requirements. The compound is classified under CLP as Aquatic Chronic 2 with GHS09 environmental pictogram, requiring appropriate labeling and safety data sheets. It is not currently listed as a Substance of Very High Concern (SVHC). Companies handling this substance must comply with registration, evaluation, and authorization requirements under REACH, including downstream user obligations and communication throughout the supply chain.

(2S)-6-fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-chromene is available through OYSI, a specialized European distributor of fine chemicals and pharmaceutical intermediates. OYSI provides reliable supply of research chemicals and industrial intermediates across Europe, ensuring compliance with REACH and CLP regulations. As a professional chemical supplier, OYSI offers proper documentation including certificates of analysis and safety data sheets. Contact OYSI directly to inquire about availability, specifications, and delivery options for this specialized chromene derivative.