2-chloro-6-(ethylamino)-4-nitrophenol
C8H9ClN2O3
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Identification
- CAS Number
- 131657-78-8
- EC Number
- 411-440-1
- UN Number
- 3077
- Index Number
- 609-059-00-2
- PubChem CID
- 9794399
Physical-chemical properties
- Molecular Formula
- C8H9ClN2O3
- Molar Mass
- 216.62 g/mol
- IUPAC Name
- 2-chloro-6-(ethylamino)-4-nitrophenol
Chemical Identifiers
- InChI
- InChI=1S/C8H9ClN2O3/c1-2-10-7-4-5(11(13)14)3-6(9)8(7)12/h3-4,10,12H,2H2,1H3
- InChI Key
- CDFNUSAXZDSXKF-UHFFFAOYSA-N
Overview
2-chloro-6-(ethylamino)-4-nitrophenol (CAS 131657-78-8) is a substituted phenolic compound with chloro, nitro, and ethylamino functional groups providing distinctive chemical reactivity. This specialized chemical intermediate features a complex molecular structure with multiple functional groups that contribute to its unique properties and applications. With the molecular formula C8H9ClN2O3 and a molecular weight of 216.62 g/mol, this compound belongs to the family of halogenated nitrophenols, which are widely used in pharmaceutical and agrochemical synthesis. The presence of chloro, nitro, and ethylamino substituents on the phenolic ring creates a molecule with specific reactivity patterns that make it valuable for targeted chemical transformations. The compound is classified under European regulations with the EC number 411-440-1 and carries important safety classifications including Acute Tox. 4, Skin Sens. 1, and Aquatic Chronic 2, requiring appropriate handling precautions during industrial use. Safety considerations are paramount when working with this material, as indicated by the GHS07 and GHS09 pictograms and "Warning" signal word. The compound falls under ADR transport class 9, requiring specific shipping and storage protocols. Like related compounds such as 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one, proper environmental controls are essential due to its aquatic toxicity classification. Primary industrial applications include its use as a chemical intermediate in pharmaceutical synthesis, as a building block for agrochemical products, and in specialty chemical manufacturing where its specific substitution pattern provides synthetic advantages. The compound's versatility makes it particularly valuable in multi-step synthesis processes requiring precise functional group manipulation. OYSI maintains reliable supply channels for 2-chloro-6-(ethylamino)-4-nitrophenol to support European industrial customers' specialized chemical requirements.
Safety & Classification
Acute Tox. 4 *; Skin Sens. 1; Aquatic Chronic 2
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Skin Contact
Measures if substance contacts the skin
First Aid Actions
- +P302IF ON SKIN:
- +P352Wash with plenty of water.
- +P361Take off immediately all contaminated clothing.
- +P313Get medical advice/attention.
Related hazard statements:
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 3077 |
| ADR Class | 9 |
| Packing Group | III |
| Tunnel Code | - |
| Proper Shipping Name | 2-Chlor-6-(ethylamino)-4-nitrophenol |
| Marine Pollutant | No |
Frequently Asked Questions
What is 2-chloro-6-(ethylamino)-4-nitrophenol?
2-chloro-6-(ethylamino)-4-nitrophenol is an organic chemical compound with the molecular formula C8H9ClN2O3 and CAS number 131657-78-8. This substituted phenol derivative contains chlorine, ethylamino, and nitro functional groups attached to a phenol ring. With a molecular weight of 216.62 g/mol, it is classified as a hazardous substance requiring proper handling precautions due to its toxicity and environmental impact potential.
What are the physicochemical properties of 2-chloro-6-(ethylamino)-4-nitrophenol?
2-chloro-6-(ethylamino)-4-nitrophenol is a solid organic compound at room temperature with a molecular weight of 216.62 g/mol. As a substituted nitrophenol, it likely exhibits characteristic coloration ranging from yellow to orange-brown. The presence of both hydrophilic (amino, nitro, hydroxyl) and hydrophobic (chloro, ethyl) groups suggests moderate solubility in polar solvents. Specific physical properties should be confirmed through technical documentation.
What is 2-chloro-6-(ethylamino)-4-nitrophenol used for?
2-chloro-6-(ethylamino)-4-nitrophenol is primarily used as a chemical intermediate in pharmaceutical and fine chemical synthesis. Its multiple functional groups make it valuable for developing active pharmaceutical ingredients, agrochemicals, and specialty dyes. The compound serves as a building block in organic synthesis processes where selective functionalization of aromatic compounds is required. Applications are typically restricted to professional industrial use due to its hazardous classification.
How to handle 2-chloro-6-(ethylamino)-4-nitrophenol safely?
2-chloro-6-(ethylamino)-4-nitrophenol requires careful handling due to its Acute Toxicity 4 and Skin Sensitization 1 classifications. Always wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume extraction systems. Avoid skin contact, inhalation, and ingestion. Use proper handling techniques to prevent dust generation and ensure all personnel are trained in chemical safety protocols.
How to store 2-chloro-6-(ethylamino)-4-nitrophenol correctly?
2-chloro-6-(ethylamino)-4-nitrophenol should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from incompatible materials. Keep away from heat sources, direct sunlight, and moisture. Store separately from strong oxidizing agents, reducing agents, and bases due to potential chemical incompatibilities. Ensure proper labeling with hazard information and maintain an inventory system. Storage areas should have appropriate spill containment measures.
What to do in case of contact with 2-chloro-6-(ethylamino)-4-nitrophenol?
Immediate action is required upon contact with 2-chloro-6-(ethylamino)-4-nitrophenol due to its toxic and sensitizing properties. For skin contact, remove contaminated clothing and rinse affected area with plenty of water for at least 15 minutes. In case of eye contact, flush immediately with water. If inhaled, move to fresh air. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult the safety data sheet for specific first aid measures.
How to dispose of 2-chloro-6-(ethylamino)-4-nitrophenol appropriately?
2-chloro-6-(ethylamino)-4-nitrophenol must be disposed of as hazardous chemical waste according to local and national environmental regulations. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Do not discharge into sewers, waterways, or soil due to its environmental hazard classification (Aquatic Chronic 2). Maintain waste disposal records and follow all applicable waste management regulations including packaging and labeling requirements for hazardous materials.
How to transport 2-chloro-6-(ethylamino)-4-nitrophenol?
2-chloro-6-(ethylamino)-4-nitrophenol is classified as ADR Class 9 (Miscellaneous dangerous substances), Packing Group III for transportation. This classification requires specific packaging, marking, and documentation according to dangerous goods regulations. Use UN-approved packaging and ensure proper hazard labels are displayed. Transport vehicles must comply with ADR requirements including equipment and driver training. Consult current dangerous goods regulations for complete shipping requirements.
Is 2-chloro-6-(ethylamino)-4-nitrophenol subject to specific regulations?
2-chloro-6-(ethylamino)-4-nitrophenol is subject to various chemical regulations including REACH registration requirements in Europe and CLP classification obligations. It is classified under GHS with Warning signal word and requires appropriate hazard pictograms (GHS07, GHS09). The substance is not currently listed as SVHC under REACH. Users must comply with occupational safety regulations, environmental protection laws, and chemical inventory reporting requirements in their respective jurisdictions.
Where to buy 2-chloro-6-(ethylamino)-4-nitrophenol in Europe?
2-chloro-6-(ethylamino)-4-nitrophenol is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides quality-assured chemical products with proper documentation including certificates of analysis and safety data sheets. As a professional chemical supplier, OYSI ensures compliance with European chemical regulations and provides technical support for industrial customers requiring this specialized intermediate compound.
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Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.