1-[[(2S,3R)-3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl]-1,2,4-triazole

1-[[(2S,3R)-3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl]-1,2,4-triazole is an organofluorine compound with the molecular formula C17H13ClFN3O and CAS number 133855-98-8. This synthetic chemical features a triazole ring system connected to a substituted oxirane structure containing both chlorine and fluorine substituents. With a molecular weight of 329.8 g/mol, it represents a complex heterocyclic compound used in specialized chemical applications requiring its unique structural properties.

1-[[(2S,3R)-3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl]-1,2,4-triazole is a solid organic compound with a molecular weight of 329.8 g/mol. The presence of halogen substituents (chlorine and fluorine) and the triazole ring system influences its chemical stability and reactivity. The compound's specific stereochemistry (2S,3R configuration) determines its three-dimensional structure and potential interactions. Detailed physical properties such as melting point, solubility, and appearance may vary depending on purity and crystalline form.

1-[[(2S,3R)-3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl]-1,2,4-triazole is primarily used as a chemical intermediate in pharmaceutical synthesis and specialized organic chemistry applications. Its unique structural features, including the triazole ring and halogenated aromatic systems, make it valuable for developing bioactive compounds. The compound may also serve as a building block in medicinal chemistry research and advanced materials science, where its specific stereochemistry and functional groups provide desired reactivity patterns.

Safe handling of 1-[[(2S,3R)-3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl]-1,2,4-triazole requires strict safety measures due to its Carc. 2 and Repr. 1B classifications. Essential protective equipment includes chemical-resistant gloves, safety goggles, and respiratory protection. Work must be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid skin contact and ingestion completely. Due to the serious health hazards indicated by GHS08 pictogram, only trained personnel should handle this substance following comprehensive safety protocols.

Proper storage of 1-[[(2S,3R)-3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl]-1,2,4-triazole requires secure, controlled conditions due to its hazardous classification. Store in tightly sealed, labeled containers in a cool, dry, well-ventilated area away from incompatible materials. Given its carcinogenic and reproductive toxicity properties, storage areas must be restricted to authorized personnel only. Maintain appropriate spill control measures and ensure containers are properly sealed to prevent environmental release, considering its Aquatic Chronic 2 classification.

Immediate action is required upon contact with 1-[[(2S,3R)-3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl]-1,2,4-triazole due to its serious health hazards. For skin contact, remove contaminated clothing immediately and wash affected area thoroughly with soap and water. In case of eye contact, rinse immediately with plenty of water for at least 15 minutes. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting. Seek immediate medical attention in all cases and provide safety data sheet to medical personnel.

Disposal of 1-[[(2S,3R)-3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl]-1,2,4-triazole must follow hazardous waste regulations due to its carcinogenic and reproductive toxicity properties. The substance must be disposed of through licensed hazardous waste contractors capable of handling carcinogenic materials. Incineration at high temperatures in approved facilities is typically required. Never dispose of through regular waste streams or pour down drains due to environmental concerns (Aquatic Chronic 2). Consult local environmental authorities for specific disposal requirements and approved facilities.

Transportation of 1-[[(2S,3R)-3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl]-1,2,4-triazole follows ADR Class 9 (Miscellaneous dangerous goods), Packing Group III regulations. This classification requires appropriate packaging, labeling, and documentation according to dangerous goods transport regulations. Packages must bear proper shipping names, UN numbers, and hazard labels. Transport vehicles require appropriate placarding and emergency response information. Only certified dangerous goods transporters should handle shipments, ensuring compliance with international transport regulations for hazardous substances.

1-[[(2S,3R)-3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl]-1,2,4-triazole is subject to comprehensive chemical regulations due to its hazardous properties. Under REACH regulation, suppliers must provide safety data sheets and registration information. The CLP regulation requires specific hazard classification (Carc. 2, Repr. 1B, Aquatic Chronic 2) and appropriate labeling with GHS08 and GHS09 pictograms. While not currently listed as SVHC, its carcinogenic and reproductive toxicity properties may trigger additional regulatory scrutiny and workplace exposure controls.

1-[[(2S,3R)-3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl]-1,2,4-triazole is available through OYSI, a specialized European distributor of technical chemicals. As an established supplier of complex organic compounds, OYSI provides this substance to qualified industrial and research customers across Europe. Due to the hazardous nature of this compound (Carc. 2, Repr. 1B), purchases require proper documentation, safety certifications, and compliance with regulatory requirements. Contact OYSI directly for availability, technical specifications, and purchasing procedures for this controlled substance.